Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety

[1]  Iuliana Ionita-Laza,et al.  De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia , 2016, Neuron.

[2]  Minna Männikkö,et al.  Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders , 2016, Nature Neuroscience.

[3]  Z. Weng,et al.  The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington’s Disease , 2015, PloS one.

[4]  E. Schadt,et al.  Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain , 2015, Translational Psychiatry.

[5]  S. Whitfield-Gabrieli,et al.  Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression , 2015, Biological Psychiatry.

[6]  Yali Dou,et al.  Hijacked in cancer: the KMT2 (MLL) family of methyltransferases , 2015, Nature Reviews Cancer.

[7]  Erica Y. Shen,et al.  Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory , 2015, The Journal of Neuroscience.

[8]  R. Fredriksson,et al.  Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. , 2015, Journal of molecular biology.

[9]  L. Pessoa,et al.  The neurobiology of emotion–cognition interactions: fundamental questions and strategies for future research , 2015, Front. Hum. Neurosci..

[10]  Laura J. Scott,et al.  Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways , 2015, Nature Neuroscience.

[11]  Erica Y. Shen,et al.  Regulation of histone H3K4 methylation in brain development and disease , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[12]  B. Velasques,et al.  Deep brain stimulation: a new treatment in mood and anxiety disorders. , 2014, CNS & neurological disorders drug targets.

[13]  G. Rumbaugh,et al.  Methamphetamine-Associated Memory Is Regulated by a Writer and an Eraser of Permissive Histone Methylation , 2014, Biological Psychiatry.

[14]  K. Sakata,et al.  Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus , 2014, Neuroscience.

[15]  Charity W. Law,et al.  voom: precision weights unlock linear model analysis tools for RNA-seq read counts , 2014, Genome Biology.

[16]  A. F. Stewart,et al.  Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant , 2014, Development.

[17]  Zhaohui S. Qin,et al.  Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. , 2014, Molecular cell.

[18]  D. Levy,et al.  Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants , 2014, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[19]  Fu-Chin Liu,et al.  Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity , 2013, Proceedings of the National Academy of Sciences.

[20]  L. Monteggia,et al.  Epigenetics and Psychiatry , 2013, Neurotherapeutics.

[21]  E. Fraenkel,et al.  Targeting H3K4 trimethylation in Huntington disease , 2013, Proceedings of the National Academy of Sciences.

[22]  L. M. Valor,et al.  Genomic Landscape of Transcriptional and Epigenetic Dysregulation in Early Onset Polyglutamine Disease , 2013, The Journal of Neuroscience.

[23]  A. F. Stewart,et al.  Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice , 2013, The Journal of Neuroscience.

[24]  A. Riggs,et al.  The Histone Methyltransferase KMT2B Is Required for RNA Polymerase II Association and Protection from DNA Methylation at the MagohB CpG Island Promoter , 2013, Molecular and Cellular Biology.

[25]  Liu Liu,et al.  High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. , 2013, Journal of the American Chemical Society.

[26]  E. Nestler,et al.  Epigenetic mechanisms of depression and antidepressant action. , 2013, Annual review of pharmacology and toxicology.

[27]  G. Martin,et al.  New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons , 2012, The European journal of neuroscience.

[28]  J. Whetstine,et al.  Histone lysine methylation dynamics: establishment, regulation, and biological impact. , 2012, Molecular cell.

[29]  N. R. Hoft,et al.  The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation. , 2012, Alcohol.

[30]  J. Biederman,et al.  Prenatal Nicotine Exposure Mouse Model Showing Hyperactivity, Reduced Cingulate Cortex Volume, Reduced Dopamine Turnover, and Responsiveness to Oral Methylphenidate Treatment , 2012, The Journal of Neuroscience.

[31]  H. Nakajima,et al.  A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain. , 2012, Journal of biotechnology.

[32]  R. Trievel,et al.  Substrate and product specificities of SET domain methyltransferases , 2011, Epigenetics.

[33]  E. Nestler,et al.  Linking molecules to mood: new insight into the biology of depression. , 2010, The American journal of psychiatry.

[34]  E. Nestler,et al.  Serum Response Factor Promotes Resilience to Chronic Social Stress through the Induction of ΔFosB , 2010, The Journal of Neuroscience.

[35]  D. Centonze,et al.  Role of Aberrant Striatal Dopamine D1 Receptor/cAMP/Protein Kinase A/DARPP32 Signaling in the Paradoxical Calming Effect of Amphetamine , 2010, The Journal of Neuroscience.

[36]  P. W. German,et al.  A Pause in Nucleus Accumbens Neuron Firing Is Required to Initiate and Maintain Feeding , 2010, The Journal of Neuroscience.

[37]  D. Molfese,et al.  Histone Methylation Regulates Memory Formation , 2010, The Journal of Neuroscience.

[38]  Madelaine Gogol,et al.  Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II , 2009, Molecular and Cellular Biology.

[39]  A. F. Stewart,et al.  The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis , 2009, Epigenetics & Chromatin.

[40]  Lior Pachter,et al.  Sequence Analysis , 2020, Definitions.

[41]  K. Lattal,et al.  Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. , 2007, Behavioral neuroscience.

[42]  J. Fisher,et al.  Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. , 2007, Cell stem cell.

[43]  D. Stein,et al.  Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders. , 2006, The Cochrane database of systematic reviews.

[44]  A. Bystritsky Treatment-resistant anxiety disorders , 2006, Molecular Psychiatry.

[45]  T. Jay,et al.  Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats , 2005, Neurobiology of Learning and Memory.

[46]  Richard A Young,et al.  Global and Hox-specific roles for the MLL1 methyltransferase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R. Jaenisch,et al.  Brain-Derived Neurotrophic Factor Is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons , 2002, The Journal of Neuroscience.

[48]  R. Carelli,et al.  An examination of nucleus accumbens cell firing during extinction and reinstatement of water reinforcement behavior in rats , 2002, Brain Research.

[49]  R. Carelli,et al.  Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats , 2000, Brain Research.

[50]  R. Malenka,et al.  Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens , 1994, Nature.

[51]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[52]  J. Schiffman,et al.  Current diagnosis and treatment of anxiety disorders. , 2013, P & T : a peer-reviewed journal for formulary management.

[53]  B. Bernstein,et al.  Charting histone modifications and the functional organization of mammalian genomes , 2011, Nature Reviews Genetics.

[54]  A. Grace,et al.  Cortico-Basal Ganglia Reward Network: Microcircuitry , 2010, Neuropsychopharmacology.

[55]  F. L. D. Silva,et al.  Contribution of NMDA receptors to postsynaptic potentials and paired-pulse facilitation in identified neurons of the rat nucleus accumbens in vitro , 2004, Experimental Brain Research.