Effects of diazepam and midazolam on recovery from anaesthesia in outpatients.

Sixty patients were randomly allocated in an open study to receive either midazolam or diazepam (Diazemuls) with fentanyl and etomidate for induction and maintenance of anaesthesia during day-stay gynaecological surgery. The excitatory effects of etomidate were controlled by the benzodiazepine-fentanyl combination in both groups. No significant difference in the quality of recovery (as judged by Trieger test analysis), amnesia, incidence of recall of pain on injection of etomidate or nausea and vomiting could be demonstrated between the groups. There was a high degree (97%) of patient acceptance.

[1]  P. Cotton,et al.  A randomized comparison of midazolam and diazepam for sedation in upper gastrointestinal endoscopy. , 1983, British journal of anaesthesia.

[2]  J. Wildsmith,et al.  Comparison of the i.v. administration of midazolam and diazepam as sedation during spinal anaesthesia. , 1983, British journal of anaesthesia.

[3]  B. Finucane,et al.  Comparison of thiopentone and midazolam for induction of anaesthesia: Influence of diazepam premedication , 1982, Canadian Anaesthetists' Society journal.

[4]  J. Dundee,et al.  Amnesic action of midazolam , 1980, Anaesthesia.

[5]  J. Dundee,et al.  Effect of preanaesthetic medication on etomidate. , 1979, British journal of anaesthesia.

[6]  A. Thorn‐Alquist.  Parenteral Use of Diazepam in an Emulsion Formulation. A Clinical Study , 1977, Acta anaesthesiologica Scandinavica.

[7]  T. Mossberg,et al.  Diazepam in Emulsion Form for Intravenous Usage , 1976, Acta anaesthesiologica Scandinavica.

[8]  B. Kay.  A dose-response relationship for etomidate, with some observations on cumulation. , 1976, British journal of anaesthesia.

[9]  B. Kay.  A clinical assessment of the use of etomidate in children. , 1976, British journal of anaesthesia.

[10]  J. Whitwam,et al.  Effect of dose and premedication on induction complications with etomidate. , 1976, British journal of anaesthesia.

[11]  D. M. Hailey,et al.  DELAYED RECOVERY FROM A SEDATIVE: CORRELATION OF THE PLASMA LEVELS OF DIAZEPAM WITH CLINICAL EFFECTS AFTER ORAL AND INTRAVENOUS ADMINISTRATION , 1972 .

[12]  N. Trieger,et al.  Measuring Recovery From Anesthesia ‐ A Simple Test , 1969, Anesthesia and analgesia.