Muscle as a consumer of lactate.

GLADDEN, L. B., Muscle as a consumer of lactate. Med. Sci. Sports Exerc., Vol. 32, No. 4, pp. 764–771, 2000. Historically, muscle has been viewed primarily as a producer of lactate but is now considered also to be a primary consumer of lactate. Among the most important factors that regulate net lact

[1]  B. Groves,et al.  Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. , 1992, Journal of applied physiology.

[2]  J. Bangsbo,et al.  Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. , 1994, Journal of applied physiology.

[3]  M. Pagliassotti,et al.  Endurance training enhances lactate clearance during hyperlactatemia. , 1989, The American journal of physiology.

[4]  M. Pagliassotti,et al.  Quantitative assessment of pathways for lactate disposal in skeletal muscle fiber types. , 2000, Medicine and science in sports and exercise.

[5]  B. Saltin,et al.  Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. , 1988, The American journal of physiology.

[6]  H. Pilegaard,et al.  Lactate transport studied in sarcolemmal giant vesicles from rat skeletal muscles: effect of denervation. , 1995, The American journal of physiology.

[7]  C. Le Peuch,et al.  Lactate uptake by skeletal muscle sarcolemmal vesicles decreases after 4 wk of hindlimb unweighting in rats. , 1996, Journal of applied physiology.

[8]  K. Tipton,et al.  Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle. , 1997, The American journal of physiology.

[9]  G. Brooks,et al.  Lactate and pyruvate transport is dominated by a pH gradient-sensitive carrier in rat skeletal muscle sarcolemmal vesicles. , 1990, Archives of biochemistry and biophysics.

[10]  J. Holloszy,et al.  Additive effect of contractions and insulin on GLUT-4 translocation into the sarcolemma. , 1994, Journal of applied physiology.

[11]  G. Brooks.  Lactate:Glycolytic End Product and Oxidative Substrate During Sustained Exercise in Mammals — The “Lactate Shuttle” , 1985 .

[12]  G. Brooks,et al.  Current concepts in lactate exchange. , 1990, Medicine and science in sports and exercise.

[13]  H. Pilegaard,et al.  Kinetics of lactate transport in sarcolemmal giant vesicles obtained from human skeletal muscle. , 1994, Journal of applied physiology.

[14]  G. Brooks,et al.  Intra- and extra-cellular lactate shuttles. , 2000, Medicine and science in sports and exercise.

[15]  L. Gladden,et al.  Effect of lactate concentration and metabolic rate on net lactate uptake by canine skeletal muscle. , 1994, The American journal of physiology.

[16]  M. Pagliassotti,et al.  Enhanced efficiency of lactate removal after endurance training. , 1990, Journal of applied physiology.

[17]  A. Halestrap,et al.  Transport of lactate and other monocarboxylates across mammalian plasma membranes. , 1993, The American journal of physiology.

[18]  J B Bassingthwaighte,et al.  Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. , 1986, The American journal of physiology.

[19]  A. Bonen,et al.  Effects of exercise on lactate transport into mouse skeletal muscles. , 1994, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[20]  M. Tarnopolsky,et al.  Increased clearance of lactate after short-term training in men. , 1995, Journal of applied physiology.

[21]  M. Rennie,et al.  L(+)-lactate transport in perfused rat skeletal muscle: kinetic characteristics and sensitivity to pH and transport inhibitors. , 1988, Biochimica et biophysica acta.

[22]  C. Slentz,et al.  Glucose transporters and maximal transport are increased in endurance-trained rat soleus. , 1992, Journal of applied physiology.

[23]  S. Hazra,et al.  Electrical relaxation mechanism in unconventional bismuth cuprate glasses , 1998 .

[24]  G. Brooks.  Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. , 1986, Federation proceedings.

[25]  Gladden Lb.  Lactate uptake by skeletal muscle. , 1989 .

[26]  D. Pascoe,et al.  Muscle Glycogen Resynthesis after Short Term, High Intensity Exercise and Resistance Exercise , 1996, Sports medicine.

[27]  A. Bonen,et al.  Lactate transport and lactate transporters in skeletal muscle. , 1997, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[28]  G. Heigenhauser,et al.  Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. , 1998, American journal of physiology. Endocrinology and metabolism.

[29]  M. Pagliassotti,et al.  Influence of cell heterogeneity on skeletal muscle lactate kinetics. , 1990, The American journal of physiology.

[30]  J. Bassingthwaighte,et al.  Modeling in the Analysis of the Processes of Uptake and Metabolism in the Whole Organ , 1998 .

[31]  A. Koch,et al.  Cellular uptake of L-lactate in mouse diaphragm. , 1981, Biophysical journal.

[32]  X Wang,et al.  Lactate transport in heart in relation to myocardial ischemia. , 1997, The American journal of cardiology.

[33]  H. Pilegaard,et al.  Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fibre type and age. , 1991, Acta physiologica Scandinavica.

[34]  J. Holloszy,et al.  Glycogen synthesis from lactate in the three types of skeletal muscle. , 1979, The Journal of biological chemistry.

[35]  A. Bonen,et al.  Endurance training increases skeletal muscle lactate transport. , 1993, Acta physiologica Scandinavica.

[36]  A. Roos.  Intracellular pH and distribution of weak acids across cell membranes. A study of D‐ and L‐lactate and of DMO in rat diaphragm. , 1975, The Journal of physiology.

[37]  D. Roth,et al.  The sarcolemmal lactate transporter: transmembrane determinants of lactate flux. , 1991, Medicine and science in sports and exercise.

[38]  E Brooks,et al.  Blood lactate disappearance at various intensities of recovery exercise. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[39]  E. Horton,et al.  Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle , 1988, FEBS letters.

[40]  A. Bonen,et al.  Lactate transport in rat sarcolemmal vesicles and intact skeletal muscle, and after muscle contraction. , 1994, Acta physiologica Scandinavica.

[41]  C. Juel.  Lactate-proton cotransport in skeletal muscle. , 1997, Physiological reviews.

[42]  E. Horton,et al.  Skeletal muscle plasma membrane glucose transport and glucose transporters after exercise. , 1990, Journal of applied physiology.

[43]  G. Brooks,et al.  Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles. , 1990, Archives of biochemistry and biophysics.

[44]  C. Juel.  Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles. , 1996, Biochimica et biophysica acta.

[45]  G. Brooks,et al.  The lactate shuttle during exercise and recovery. , 1986, Medicine and science in sports and exercise.

[46]  H. Pilegaard,et al.  Lactate transport studied in sarcolemmal giant vesicles from rats: effect of training. , 1993, The American journal of physiology.

[47]  Mann Ge,et al.  Unidirectional uptake of substrates at the blood side of secretory epithelia: stomach, salivary gland, pancreas. , 1982 .

[48]  G. Heigenhauser,et al.  Lactate metabolism in inactive skeletal muscle during lactacidosis. , 1991, American Journal of Physiology.

[49]  G. Brooks,et al.  Endurance training affects lactate clearance, not lactate production. , 1983, The American journal of physiology.

[50]  C. Juel.  Muscle lactate transport studied in sarcolemmal giant vesicles. , 1991, Biochimica et biophysica acta.

[51]  A. Bonen,et al.  Glycogenesis and glyconeogenesis in skeletal muscle: effects of pH and hormones. , 1990, The American journal of physiology.

[52]  L. Gladden.  Net lactate uptake during progressive steady-level contractions in canine skeletal muscle. , 1991, Journal of applied physiology.

[53]  L. Gladden,et al.  Lactic acid infusion in dogs: effects of varying infusate pH. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[54]  R. Herrick,et al.  Lactate oxidative capacity in different types of muscle. , 1978, Biochemical and biophysical research communications.

[55]  D. Kipnis,et al.  Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle. , 1985, The American journal of physiology.

[56]  B. A. Wilson,et al.  Skeletal muscle lactate release and glycolytic intermediates during hypercapnia. , 1986, Journal of applied physiology.

[57]  M. Pagliassotti,et al.  Glycogenesis from lactate in rabbit skeletal muscle fiber types. , 1990, The American journal of physiology.

[58]  J. Katz,et al.  Lactate metabolism in the perfused rat hindlimb. , 1984, The Biochemical journal.

[59]  W. A. Shaw,et al.  Lactate metabolism in resting and exercising dogs. , 1976, Journal of applied physiology.

[60]  A. Bonen,et al.  Lactate transporters (MCT proteins) in heart and skeletal muscles. , 2000, Medicine & Science in Sports & Exercise.

[61]  M. Pagliassotti,et al.  Role of cell type in net lactate removal by skeletal muscle. , 1990, The American journal of physiology.

[62]  B. Ameredes,et al.  Blood flow and pressure relationships which determine VO2max. , 1995, Medicine and science in sports and exercise.

[63]  A. Bonen,et al.  Reduced lactate transport in denervated rat skeletal muscle. , 1995, The American journal of physiology.

[64]  T D Noakes,et al.  Effects of training on lactate production and removal during progressive exercise in humans. , 1992, Journal of applied physiology.

[65]  H. T. Edwards,et al.  The rate of lactic acid removal in exercise. , 1937 .

[66]  M. Rennie,et al.  Characteristics of L‐glutamine transport in perfused rat skeletal muscle. , 1987, The Journal of physiology.

[67]  J T Reeves,et al.  Decreased reliance on lactate during exercise after acclimatization to 4,300 m. , 1991, Journal of applied physiology.