Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

[1]  Judith L. Strymish,et al.  Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study , 2021, PloS one.

[2]  H. Nakaya,et al.  Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. , 2021, Blood.

[3]  V. Nizet,et al.  Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation , 2021, Scientific Reports.

[4]  G. Bowlin,et al.  Patients with COVID-19: in the dark-NETs of neutrophils , 2021, Cell Death & Differentiation.

[5]  A. Takaoka,et al.  RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells , 2021, Nature Immunology.

[6]  F. Cunha,et al.  Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial , 2021, RMD Open.

[7]  Hong Luo,et al.  Spectrum and Clinical Characteristics of Symptomatic and Asymptomatic Coronavirus Disease 2019 (COVID-19) With and Without Pneumonia , 2020, Frontiers in Medicine.

[8]  Raphael Gottardo,et al.  Integrated analysis of multimodal single-cell data , 2020, Cell.

[9]  P. Delvenne,et al.  Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 , 2020, The Journal of experimental medicine.

[10]  P. Saldiva,et al.  SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology , 2020, The Journal of experimental medicine.

[11]  M. Neurath,et al.  Vascular occlusion by neutrophil extracellular traps in COVID-19 , 2020, EBioMedicine.

[12]  N. Lopes,et al.  Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vitro Biological Results for SARS-CoV-2 , 2020, Journal of the Brazilian Chemical Society.

[13]  C. Hallam,et al.  Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice , 2020, Nature Communications.

[14]  C. Takiya,et al.  The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19) , 2020, Scientific Reports.

[15]  V. Hoffmann,et al.  Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis. , 2020, JCI insight.

[16]  Yiming Xu,et al.  A novel cell-based assay for dynamically detecting neutrophil extracellular traps-induced lung epithelial injuries , 2020, Experimental Cell Research.

[17]  I. Amit,et al.  Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 , 2020, Nature Medicine.

[18]  W. Gong,et al.  Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. , 2020, JAMA cardiology.

[19]  J. Lieberman,et al.  FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation , 2020, Nature Immunology.

[20]  G. Herrler,et al.  SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor , 2020, Cell.

[21]  Chao Zhang,et al.  Liver injury in COVID-19: management and challenges , 2020, The Lancet Gastroenterology & Hepatology.

[22]  J. Xiang,et al.  Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study , 2020, The Lancet.

[23]  Zunyou Wu,et al.  Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. , 2020, JAMA.

[24]  Wenling Wang,et al.  The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice , 2020, Nature.

[25]  Yan Zhao,et al.  A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) , 2020, Military Medical Research.

[26]  F. Shao,et al.  The gasdermins, a protein family executing cell death and inflammation , 2019, Nature Reviews Immunology.

[27]  P. Zanotto,et al.  Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy , 2019, PLoS neglected tropical diseases.

[28]  B. Porto,et al.  Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation , 2018, Scientific Reports.

[29]  R. Krüger,et al.  Gasdermin D plays a vital role in the generation of neutrophil extracellular traps , 2018, Science Immunology.

[30]  K. Schroder,et al.  Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps , 2018, Science Immunology.

[31]  R. Cook,et al.  Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment , 2018, Oncotarget.

[32]  T. Cheng,et al.  Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death , 2018, Cell reports.

[33]  V. Papayannopoulos Neutrophil extracellular traps in immunity and disease , 2017, Nature Reviews Immunology.

[34]  P. Kubes,et al.  An emerging role for neutrophil extracellular traps in noninfectious disease , 2017, Nature Medicine.

[35]  F. Cunha,et al.  Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis , 2016, PloS one.

[36]  T. Cai,et al.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.

[37]  C. Bonorino,et al.  Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils , 2015, PloS one.

[38]  Hanspeter Pfister,et al.  UpSet: Visualization of Intersecting Sets , 2014, IEEE Transactions on Visualization and Computer Graphics.

[39]  P. Thompson,et al.  Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis , 2014, Circulation research.

[40]  Vindhya Koppaka,et al.  Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application , 2012, Pharmacological Reviews.

[41]  Matthias Kretzler,et al.  Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus , 2011, The Journal of Immunology.

[42]  P. Kovanen,et al.  Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 31 , 2008, The Journal of Immunology.

[43]  David K. Meyerholz,et al.  Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus , 2006, Journal of Virology.

[44]  A. Zychlinsky,et al.  Neutrophil Extracellular Traps Kill Bacteria , 2004, Science.

[45]  R. Moore,et al.  Disulfiram treatment of alcoholism. , 1990, The American journal of medicine.

[46]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..