Gene–gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women

Aims  Recent studies indicate transcription factor hepatocyte nuclear factor 4α (HNF‐4α, HNF4A) modulates the transcription of the pancreatic B‐cell ATP‐sensitive K+ (KATP) channel subunit Kir6.2 gene (KCNJ11). Both HNF4A and KCNJ11 have previously been associated with diabetes risk but little is known whether the variations in these genes interact with each other.

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