Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein

[1]  R. Bowditch,et al.  Restricted endothelial cell expression of gravin in vivo , 1994, The Anatomical record.

[2]  E. Sutherland,et al.  Studies on the mechanism of hormone action. , 1972, Science.

[3]  C. Rubin,et al.  A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. , 1994, Biochimica et biophysica acta.

[4]  J. Scott,et al.  Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. , 1994, The Journal of biological chemistry.

[5]  S. L. Hyatt,et al.  Protein kinase C domains involved in interactions with other proteins. , 1994, Biochemistry.

[6]  J. Scott,et al.  Localization of A-kinase through anchoring proteins. , 1994, Molecular endocrinology.

[7]  S. Hirai,et al.  Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate. , 1994, The Journal of biological chemistry.

[8]  J Staudinger,et al.  PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system , 1995, The Journal of cell biology.

[9]  L. Langeberg,et al.  Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase. , 1994, The Journal of biological chemistry.

[10]  U. Walter,et al.  High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[11]  W. Theurkauf,et al.  Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2. , 1982, The Journal of biological chemistry.

[12]  A. Aderem.  The Marcks brothers: A family of protein kinase C substrates , 1992, Cell.

[13]  Y. Nishizuka.  Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. , 1992, Science.

[14]  I. Fraser,et al.  Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. , 1991, The Journal of biological chemistry.

[15]  Brian A. Hemmings,et al.  The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase , 1993, Cell.

[16]  R. Kannagi,et al.  Human erythroleukemia cell line (HEL) undergoes a drastic macrophage-like shift with TPA. , 1983, Blood.

[17]  M. Wigler,et al.  Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Rubin Cs.  A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. , 1994 .

[19]  J. Lindstrom.  Immunobiology of myasthenia gravis, experimental autoimmune myasthenia gravis, and Lambert-Eaton syndrome. , 1985, Annual review of immunology.

[20]  D. Mochly‐Rosen.  Localization of protein kinases by anchoring proteins: a theme in signal transduction. , 1995, Science.

[21]  P. Cohen,et al.  On target with a new mechanism for the regulation of protein phosphorylation. , 1993, Trends in biochemical sciences.

[22]  D. Mochly‐Rosen,et al.  Identification of intracellular receptor proteins for activated protein kinase C. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Tony Pawson,et al.  Protein modules and signalling networks , 1995, Nature.

[24]  John D. Scott,et al.  Molecular Glue: Kinase Anchoring and Scaffold Proteins , 1996, Cell.

[25]  J. Scott,et al.  More on target with protein phosphorylation: conferring specificity by location. , 1996, Trends in biochemical sciences.

[26]  E. Elion,et al.  Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae , 1994, Cell.

[27]  A. Newton,et al.  Requirement for negative charge on "activation loop" of protein kinase C. , 1994, The Journal of biological chemistry.

[28]  G. Gill,et al.  The enigma of LIM domains. , 1995, Structure.

[29]  S. Kiley,et al.  Identification of a Major Protein Kinase C-binding Protein and Substrate in Rat Embryo Fibroblasts , 1996, The Journal of Biological Chemistry.

[30]  L. Langeberg,et al.  Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein , 1996, Science.

[31]  S. Durbin,et al.  High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0 , 1996, The Journal of Biological Chemistry.

[32]  K. Ramsay,et al.  Interaction cloning of protein kinase C substrates. , 1993, The Journal of biological chemistry.

[33]  C. Lowe,et al.  The Resonant Mirror: A Versatile Tool for the Study of Biomolecular Interactions , 1994 .

[34]  Philip R. Cohen,et al.  Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M , 1994, FEBS letters.

[35]  Christian Rosenmund,et al.  Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons , 1994, Nature.

[36]  J. Scott,et al.  Cloning and Characterization of a Novel A-kinase Anchoring Protein , 1996, The Journal of Biological Chemistry.

[37]  T. Hunter,et al.  Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling , 1995, Cell.

[38]  I. Herskowitz.  MAP kinase pathways in yeast: For mating and more , 1995, Cell.

[39]  J. Beattie,et al.  Determination of the Structure of the N-terminal Splice Region of the Cyclic AMP-specific Phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and Identification of the Membrane Association Domain Using Chimeric Constructs* , 1996, The Journal of Biological Chemistry.

[40]  F. Sanger,et al.  DNA sequencing with chain-terminating inhibitors. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[41]  L. Langeberg,et al.  Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. , 1995, Science.

[42]  E. Price,et al.  Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 , 1996, Nature.

[43]  A. Newton.  Protein kinase C: Ports of anchor in the cell , 1996, Current Biology.

[44]  I. Fraser,et al.  Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. , 1992, The Journal of biological chemistry.

[45]  J. Lindstrom,et al.  Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. , 1992, The Journal of clinical investigation.

[46]  J. Otto,et al.  Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site (*) , 1996, The Journal of Biological Chemistry.

[47]  P. Nelson,et al.  Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras , 1995, Molecular and cellular biology.

[48]  G. Sprague,,et al.  Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. , 1994, Genetics.