This volume constitutes the refereed proceedings of the 16th EuroSPI conference in Alcala (Madrid region) during September 2-4. The 18 revised full papers presented were carefully reviewed and selected. They are organized in topical sections on SPI and the testing process; SPI measurement and assessment; agile and open source issues; SPI and management issues; process life cycle and quality issues; standards and reference models. This textbook is intended for the use by SPI (Software Process Improvement) managers and researchers, quality managers, and experienced project and research managers.