A case of advanced non-Hodgkin's lymphoma involving the prostate: staging and treatment monitoring using F-18 FDG PET/CT imaging.

Prostate involvement by non Hodgkin lymphoma (NHL) is particularly rare and occurs in less than 1% of all NHL patients. We report the case of a 44-year-old man with a follicular lymphoma transformed into an aggressive CD20 B-cell lymphoma involving the prostate. He was successfully treated with chemotherapy followed by therapeutic intensification using autologous bone marrow transplantation. Positron emission tomography (PET) using F-18 fluorodeoxyglucose combined with computed tomography performed at staging, during chemotherapy and after the completion of treatment proved useful for assessing prostate infiltration by NHL.

[1]  B. Cheson,et al.  The role of FDG-PET scans in patients with lymphoma. , 2007, Blood.

[2]  Jinhua Zhao,et al.  Therapeutic evaluation and prognostic value of interim hybrid PET/CT with 18F-FDG after three to four cycles of chemotherapy in non-Hodgkin's lymphoma , 2007, Hematology.

[3]  E. Lin FDG PET/CT flip flop phenomenon in treated lymphoma of bone. , 2006, Clinical nuclear medicine.

[4]  M. O'Doherty,et al.  FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[5]  P. Chu,et al.  Incidental and Concurrent Malignant Lymphomas Discovered at the Time of Prostatectomy and Prostate Biopsy: A Study of 29 Cases , 2005, The American journal of surgical pathology.

[6]  R. P. Spencer,et al.  B cell lymphoma: a case with localized involvement of the prostate on F-18-FDG examination. , 2005, Clinical nuclear medicine.

[7]  J. Karstens,et al.  Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[8]  D. Bostwick,et al.  Malignant lymphoma involving the prostate , 1998, Cancer.

[9]  E. Henderson,et al.  Primary prostatic involvement in non-Hodgkin lymphoma. , 1988, Urology.

[10]  D. Bostwick,et al.  Malignant lymphomas involving the prostate a study of 13 cases , 1985, Cancer.

[11]  J. Berg,et al.  Occurrence and prognosis of extranodal lymphomas , 1972, Cancer.