A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

Virchow‐Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field.

[1]  Monique M. B. Breteler,et al.  The Rotterdam Study: 2016 objectives and design update , 2015, European Journal of Epidemiology.

[2]  Nick C Fox,et al.  Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration , 2013, The Lancet Neurology.

[3]  B. Zlokovic.  The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.

[4]  Mark A. Elliott,et al.  The feasibility of quantitative MRI of perivascular spaces at 7T , 2015, Journal of Neuroscience Methods.

[5]  Andreas Charidimou,et al.  MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[6]  Karen J. Ferguson,et al.  Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel Disease , 2010, Stroke.

[7]  B. Mazoyer,et al.  Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition , 2014, Neurobiology of Aging.

[8]  Maiken Nedergaard,et al.  The Glymphatic System: A Beginner’s Guide , 2015, Neurochemical Research.

[9]  Evan Fletcher,et al.  Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study , 2012, The Lancet Neurology.

[10]  Maiken Nedergaard,et al.  Impairment of paravascular clearance pathways in the aging brain , 2014, Annals of neurology.

[11]  D. Neary,et al.  Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementia. , 2005, AJNR. American journal of neuroradiology.

[12]  D. Harvey,et al.  Measures of brain morphology and infarction in the framingham heart study: establishing what is normal , 2005, Neurobiology of Aging.

[13]  W. Niessen,et al.  Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[14]  C. DeCarli,et al.  Managing and analysing data from a large‐scale study on Framingham Offspring relating brain structure to cognitive function , 2004, Statistics in medicine.

[15]  C. Dufouil,et al.  Inflammatory proteins and the severity of dilated Virchow-Robin Spaces in the elderly. , 2012, Journal of Alzheimer's disease : JAD.

[16]  I. Deary,et al.  Towards the automatic computational assessment of enlarged perivascular spaces on brain magnetic resonance images: A systematic review , 2013, Journal of magnetic resonance imaging : JMRI.

[17]  P. Scheltens,et al.  Measuring progression of cerebral white matter lesions on MRI , 2004, Neurology.

[18]  H. Chabriat,et al.  Dilation of Virchow‐Robin spaces in CADASIL , 2006, European journal of neurology.

[19]  A. Hofman,et al.  Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. , 2000, Stroke.

[20]  Benjamin F. J. Verhaaren,et al.  Rating Method for Dilated Virchow–Robin Spaces on Magnetic Resonance Imaging , 2013, Stroke.

[21]  Karen J. Ferguson,et al.  Enlarged perivascular spaces are associated with cognitive function in healthy elderly men , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[22]  F. Fazekas,et al.  MRI white matter hyperintensities , 1999, Neurology.

[23]  W. Chen,et al.  Assessment of the Virchow-Robin Spaces in Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging, Using High-Field MR Imaging , 2011, American Journal of Neuroradiology.

[24]  Wiro J. Niessen,et al.  The Rotterdam Scan Study: design and update up to 2012 , 2011, European Journal of Epidemiology.

[25]  R. Carare,et al.  SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease , 2007 .

[26]  A. Hofman,et al.  Incidental findings on brain MRI in the general population. , 2007, The New England journal of medicine.

[27]  W. Rathmann,et al.  Cohort profile: the study of health in Pomerania. , 2011, International journal of epidemiology.

[28]  J. Wardlaw,et al.  Cerebral Perivascular Spaces Visible on Magnetic Resonance Imaging: Development of a Qualitative Rating Scale and its Observer Reliability , 2015, Cerebrovascular Diseases.

[29]  A. Hofman,et al.  Raised blood pressure and plasma noradrenaline concentrations in teenagers and young adults selected from an open population. , 1979, British medical journal.

[30]  Jean-Claude Baron,et al.  Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[31]  B. Mazoyer,et al.  Severity of Dilated Virchow-Robin Spaces Is Associated With Age, Blood Pressure, and MRI Markers of Small Vessel Disease: A Population-Based Study , 2010, Stroke.

[32]  M. A. Ikram,et al.  Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis , 2011, Neurobiology of Aging.

[33]  S. Groeschel,et al.  Virchow-Robin spaces on magnetic resonance images: normative data, their dilatation, and a review of the literature , 2006, Neuroradiology.

[34]  Aad van der Lugt,et al.  DETERMINANTS OF ENLARGED VIRCHOW-ROBIN SPACES: THE UNIVRSE CONSORTIUM , 2014, Alzheimer's & Dementia.

[35]  T. Wong,et al.  Prevalence of cognitive impairment in Chinese: Epidemiology of Dementia in Singapore study , 2013, Journal of Neurology, Neurosurgery & Psychiatry.