Genome System Architecture and Natural Genetic Engineering

Molecular genetics reveals three aspects of genome organization and reorganization that provide opportunities for formulating new views of the evolutionary process: 1 Organization of the genome as a hierarchy of systems (not units) determining many aspects of genetic function (only some of which are specifying protein and RNA sequences); 2 The presence of many repetitive DNA elements in the genome which do not encode protein or RNA structure but serve as the physical basis for functional integration; and 3 The operation of regulated cellular natural genetic engineering systems capable of rearranging basic genomic components throughout the genome in a single cell generation.

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