IMPROVEMENT OF DISSOLUTION BEHAVIOR OF PARACETAMOL USING SOLID DISPERSION TECHNIQUE

Paracetamol is an important anti-inflammatory and analgesic drug widely used in biological disorders. One of major problems with this drugs is its low solubility thus dissolution rate in biological fluid, which results into poor bioavailability after oral administration. In this study polyvinyl pyrrolidone (PVP) is used to enhance bioavailability of paracetamol. Paracetamol and PVP are used in 1:1 and 1:2 ratios to study the effect of PVP in dissolution profile of drug. Dissolution study showed a linear increase in paracetamol release with increase in polymer concentration. Two different batches of granules are also evaluated for their micromeritics properties and flow behavior. The micromeritics properties and dissolution profile showed a evident that PVP can be used to improve dissolution behavior of paracetamol.

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