Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors

Nutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, and unintentional weight loss (UWL) in the prior 6 months and chemotherapy toxicity among older adults with solid tumors.

[1]  B. Edwards,et al.  Malnutrition and overall survival in older adults with cancer: A systematic review and meta-analysis. , 2019, Journal of geriatric oncology.

[2]  A. Gossum,et al.  GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. , 2019, Clinical nutrition.

[3]  Y. Ba,et al.  Nutritional Risk Assessment by Scored Patient-Generated Subjective Global Assessment Associated with Demographic Characteristics in 23,904 Common Malignant Tumors Patients , 2019, Nutrition and cancer.

[4]  S. Preston,et al.  Patterns of weight change associated with disease diagnosis in a national sample , 2018, PloS one.

[5]  M. Fakih,et al.  Patient-defined goals and preferences among older adults with cancer starting chemotherapy (CT). , 2018 .

[6]  H. Cohen,et al.  Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  Matthew Wongchenko,et al.  Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis. , 2018, The Lancet. Oncology.

[8]  S. Ikeda,et al.  Serum albumin level as a potential marker for deciding chemotherapy or best supportive care in elderly, advanced non-small cell lung cancer patients with poor performance status , 2017, BMC Cancer.

[9]  D. Lobo,et al.  ESPEN expert group recommendations for action against cancer-related malnutrition. , 2017, Clinical nutrition.

[10]  Xueli Zhang,et al.  Obesity Paradox in Lung Cancer Prognosis: Evolving Biological Insights and Clinical Implications , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[11]  Craig M. Hales,et al.  Prevalence of Obesity Among Adults and Youth: United States, 2015-2016. , 2017, NCHS data brief.

[12]  A. Farcomeni,et al.  Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study , 2017, Oncotarget.

[13]  J. Meyerhardt,et al.  Explaining the Obesity Paradox: The Association between Body Composition and Colorectal Cancer Survival (C-SCANS Study) , 2017, Cancer Epidemiology, Biomarkers & Prevention.

[14]  G. Williams,et al.  The Obesity Paradox in Cancer—Moving beyond BMI—Response , 2017, Cancer Epidemiology, Biomarkers & Prevention.

[15]  L. Thuler,et al.  Undernutrition as independent predictor of early mortality in elderly cancer patients. , 2017, Nutrition.

[16]  M. Leblanc,et al.  Association between Body Mass Index and Cancer Survival in a Pooled Analysis of 22 Clinical Trials , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[17]  H. Cohen,et al.  Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  J. Meyerhardt,et al.  Analysis of Body Mass Index and Mortality in Patients With Colorectal Cancer Using Causal Diagrams. , 2016, JAMA oncology.

[19]  Young Saing Kim,et al.  Prognostic Significance of CT-Determined Sarcopenia in Patients with Small-Cell Lung Cancer , 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[20]  H. Wildiers,et al.  International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  H. Cohen,et al.  Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  D. Houston,et al.  Weight Change, Body Composition, and Risk of Mobility Disability and Mortality in Older Adults: A Population‐Based Cohort Study , 2014, Journal of the American Geriatrics Society.

[23]  M. Kovarik,et al.  Clinically relevant determinants of body composition, function and nutritional status as mortality predictors in lung cancer patients. , 2014, Lung cancer.

[24]  C. Nowson,et al.  BMI and all-cause mortality in older adults: a meta-analysis. , 2014, The American journal of clinical nutrition.

[25]  E. Arias United States life tables, 2009. , 2014, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System.

[26]  Joseph A Hill United States Life Tables , 2013 .

[27]  F. Hu,et al.  Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. , 2013, The lancet. Diabetes & endocrinology.

[28]  D. McMillan The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. , 2013, Cancer treatment reviews.

[29]  O. Mir,et al.  Sarcopenia and body mass index predict sunitinib-induced early dose-limiting toxicities in renal cancer patients , 2013, British Journal of Cancer.

[30]  K. Flegal,et al.  Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories , 2012 .

[31]  O. Mir,et al.  Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma , 2012, PloS one.

[32]  A. Ravaud,et al.  Predictors of early death risk in older patients treated with first-line chemotherapy for cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  G. Jensen,et al.  Consensus statement: Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). , 2012, JPEN. Journal of parenteral and enteral nutrition.

[34]  L. Mariani,et al.  The nutritional risk in oncology: a study of 1,453 cancer outpatients , 2012, Supportive Care in Cancer.

[35]  Supriya G Mohile,et al.  Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  L. Sørbye Cancer in home care: unintended weight loss and ethical challenges. A cross-sectional study of older people at 11 sites in Europe. , 2011, Archives of gerontology and geriatrics.

[37]  M. Neuman,et al.  Global trends in body-mass index , 2011, The Lancet.

[38]  F. Schick,et al.  Global trends in body-mass index , 2011, The Lancet.

[39]  J. Holroyd-Leduc,et al.  Unintentional weight loss in older adults , 2011, Canadian Medical Association Journal.

[40]  D. Gupta,et al.  Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature , 2010, Nutrition journal.

[41]  Matthias Pirlich,et al.  Cutoff percentiles of bioelectrical phase angle predict functionality, quality of life, and mortality in patients with cancer. , 2010, The American journal of clinical nutrition.

[42]  L. Birdsell,et al.  Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

[43]  O. Arrieta,et al.  Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study , 2010, BMC Cancer.

[44]  P. Bachmann,et al.  Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres , 2010, British Journal of Cancer.

[45]  Tony Reiman,et al.  Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. , 2008, The Lancet. Oncology.

[46]  Tony Reiman,et al.  Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity , 2007, Clinical Cancer Research.

[47]  I. Janssen,et al.  Elevated body mass index and mortality risk in the elderly , 2007, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[48]  G. Giles,et al.  Increasing underrepresentation of elderly patients with advanced colorectal or non‐small‐cell lung cancer in chemotherapy trials , 2006, Internal medicine journal.

[49]  B. Campillo,et al.  Increased risk of alteration of nutritional status in hospitalized elderly patients with advanced cancer. , 2006, The journal of nutrition, health & aging.

[50]  M. Correia,et al.  The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. , 2003, Clinical nutrition.

[51]  Joy H. Lewis,et al.  Participation of patients 65 years of age or older in cancer clinical trials. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[52]  M. Christian,et al.  How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[53]  L. Fried,et al.  Weight Change in Old Age and its Association with Mortality , 2001, Journal of the American Geriatrics Society.

[54]  C. McArdle,et al.  Albumin Concentrations Are Primarily Determined by the Body Cell Mass and the Systemic Inflammatory Response in Cancer Patients With Weight Loss , 2001, Nutrition and cancer.

[55]  C. Coltman,et al.  Underrepresentation of patients 65 years of age or older in cancer-treatment trials. , 1999, The New England journal of medicine.

[56]  R Brookmeyer,et al.  Reliability of the Blessed Telephone Information-Memory-Concentration Test , 1995, Journal of geriatric psychiatry and neurology.

[57]  Diane Podsiadlo,et al.  The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons , 1991, Journal of the American Geriatrics Society.

[58]  A. Jemal,et al.  Cancer statistics, 2015 , 2015, CA: a cancer journal for clinicians.

[59]  H. Cohen,et al.  Senior adult oncology, version 2.2014: clinical practice guidelines in oncology . , 2014, Journal of the National Comprehensive Cancer Network : JNCCN.

[60]  Ian G. Cook,et al.  Aging in the United States , 2012 .

[61]  Stanley Lemeshow,et al.  Applied Logistic Regression, Second Edition , 1989 .

[62]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[63]  W. Youden,et al.  Index for rating diagnostic tests , 1950, Cancer.

[64]  D. Karnofsky The clinical evaluation of chemotherapeutic agents in cancer , 1949 .