During transonic and supersonic wind tunnel test, air-supply pressure pipeline can generate strong vibration, and the long-term large-amplitude vibration of the pipeline can cause fatigue fracture and even severely influence the long- term reliable operation of the wind tunnel equipment. Therefore, it is greatly significant to research the vibration attenuation technology for the wind tunnel air-supply pressure pipeline. In allusion to the fluid-structure interaction vibration problem of pressure pipeline system, the vibration spectrum is measured through time-domain signal to test the vibration performance of certain pipeline under different working condition parameters and research the pipeline vibration attenuation technology. Specifically, passive control technology and numerical simulation method are adopted to research the correlation between vibration amplitude, vibration velocity and spring stiffness, damping under pressure pulsation excitation. Afterwards, suitable elastic damper, viscous damper and installation position are selected according to numerical simulation result. Finally, the experimental verification result shows: it is safe and reliable to firstly predict the vibration performance of the pressure pipeline system with complex spatial arrangement through numerical simulation method and then perform the vibration attenuation design; the maximum vibration amplitude of the improved pressure pipeline system can be maximally reduced by 62.26%, which fully satisfies the expectation.