Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats

[1]  Yingmei Wang,et al.  The therapeutic significance of aromatase inhibitors in endometrial carcinoma. , 2014, Gynecologic oncology.

[2]  S. Asthana,et al.  Effects of hormone therapy on cognition and mood. , 2014, Fertility and sterility.

[3]  Bryan W. Camp,et al.  An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms , 2013, Brain Research.

[4]  L. Rubin,et al.  Cognition in perimenopause: the effect of transition stage , 2013, Menopause.

[5]  M. Untch,et al.  Aromatase inhibitors in the treatment of elderly women with metastatic breast cancer. , 2013, Breast.

[6]  Bryan W. Camp,et al.  High serum androstenedione levels correlate with impaired memory in the surgically menopausal rat: a replication and new findings , 2012, The European journal of neuroscience.

[7]  J. Talboom,et al.  Continuous estrone treatment impairs spatial memory and does not impact number of basal forebrain cholinergic neurons in the surgically menopausal middle-aged rat , 2012, Hormones and Behavior.

[8]  H. Bimonte-Nelson,et al.  Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time , 2011, Psychopharmacology.

[9]  J. Talboom,et al.  Neuroscientists as Cartographers: Mapping the Crossroads of Gonadal Hormones, Memory and Age Using Animal Models , 2010, Molecules.

[10]  H. Bimonte-Nelson,et al.  The cognitive effects of conjugated equine estrogens depend on whether menopause etiology is transitional or surgical. , 2010, Endocrinology.

[11]  J. Bohacek,et al.  Transient estradiol exposure during middle age in ovariectomized rats exerts lasting effects on cognitive function and the hippocampus. , 2010, Endocrinology.

[12]  Craig K. Enders,et al.  Transitional versus surgical menopause in a rodent model: etiology of ovarian hormone loss impacts memory and the acetylcholine system. , 2009, Endocrinology.

[13]  J. Raber,et al.  Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. , 2009, Learning & memory.

[14]  M. Mapstone,et al.  Memory complaints and memory performance in the menopausal transition , 2009, Menopause.

[15]  R. Santen,et al.  History of aromatase: saga of an important biological mediator and therapeutic target. , 2009, Endocrine reviews.

[16]  S. West,et al.  Higher levels of estradiol replacement correlate with better spatial memory in surgically menopausal young and middle-aged rats , 2008, Neurobiology of Learning and Memory.

[17]  K. Francis,et al.  Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle‐aged ovariectomized female rats , 2006, The European journal of neuroscience.

[18]  R. Gibbs.  Testosterone and estradiol produce different effects on cognitive performance in male rats , 2005, Hormones and Behavior.

[19]  H Kuhl,et al.  Pharmacology of estrogens and progestogens: influence of different routes of administration , 2005, Climacteric : the journal of the International Menopause Society.

[20]  Sterling C. Johnson,et al.  Clinical Pharmacology and Differential Cognitive Efficacy of Estrogen Preparations , 2005, Annals of the New York Academy of Sciences.

[21]  S. Bhasin,et al.  Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. , 2005, The Journal of clinical endocrinology and metabolism.

[22]  P. Hoyer,et al.  The Follicle-Deplete Mouse Ovary Produces Androgen1 , 2004, Biology of reproduction.

[23]  David A. Johnson,et al.  Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat , 2004, Psychoneuroendocrinology.

[24]  C. Frye,et al.  Mnemonic effects of testosterone and its 5α-reduced metabolites in the conditioned fear and inhibitory avoidance tasks , 2004, Pharmacology Biochemistry and Behavior.

[25]  R. Sprando,et al.  Effects of androstenedione on in utero development in rats. , 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  A. Granholm,et al.  Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats , 2003, Experimental Neurology.

[27]  P. Hoyer,et al.  Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide. , 2002, Reproductive toxicology.

[28]  V. Denenberg,et al.  Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex , 2002, Behavioural Brain Research.

[29]  L. Mucke,et al.  Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits , 2002, The Journal of Neuroscience.

[30]  M. Young,et al.  Complexities of androgen action. , 2001, Journal of the American Academy of Dermatology.

[31]  V. Denenberg,et al.  In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze , 2000, Physiology & Behavior.

[32]  R. Gibbs.  Estrogen Replacement Enhances Acquisition of a Spatial Memory Task and Reduces Deficits Associated with Hippocampal Muscarinic Receptor Inhibition , 1999, Hormones and Behavior.

[33]  V. Denenberg,et al.  Estradiol facilitates performance as working memory load increases , 1999, Psychoneuroendocrinology.

[34]  A. Flanagan,et al.  Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat. , 1998, American journal of physiology. Endocrinology and metabolism.

[35]  W. B. Quay,et al.  Hormones and Aging , 1995 .

[36]  J. Morley,et al.  Age-related decrease of plasma testosterone in SAMP8 mice: Replacement improves age-related impairment of learning and memory , 1995, Physiology & Behavior.

[37]  D. Olton,et al.  Age-related spatial reference and working memory deficits assessed in the water maze , 1995, Neurobiology of Aging.

[38]  K. Imai,et al.  Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium. , 1992, Human reproduction.

[39]  D. Kimura,et al.  The relationship between testosterone levels and cognitive ability patterns , 1991, Psychoneuroendocrinology.

[40]  T. H. van der Kwast,et al.  Androgen receptor expression in human tissues: an immunohistochemical study. , 1991, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[41]  L. Swanson,et al.  Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study , 1990, The Journal of comparative neurology.

[42]  R. Morris,et al.  Place navigation impaired in rats with hippocampal lesions , 1982, Nature.

[43]  J. Tait,et al.  Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone. , 1966, The Journal of clinical investigation.

[44]  L. Galea,et al.  Low Doses of 17α-Estradiol and 17β-Estradiol Facilitate, Whereas Higher Doses of Estrone and 17α- and 17β-Estradiol Impair, Contextual Fear Conditioning in Adult Female Rats , 2010, Neuropsychopharmacology.

[45]  A. Meikle.  Ovarian Androgen Production in Postmenopausal Women , 2008 .

[46]  J. Daniel,et al.  Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation. , 2006, Endocrinology.

[47]  S. Lu,et al.  Printed in U.S.A. Copyright © 1998 by The Endocrine Society Androgen Receptor in Mouse Brain: Sex Differences and Similarities in Autoregulation* , 2022 .