From In Situ to In Vivo: An In Situ Click‐Chemistry‐Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography

CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses (19) F-bearing fragments as (18) F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.

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