Molecular mechanisms of axon guidance.

[1]  R. Sperry CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[2]  P. Medawar Advice To A Young Scientist , 1979 .

[3]  L. Landmesser,et al.  Pathway selection by embryonic chick motoneurons in an experimentally altered environment , 1981, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[4]  A Gierer,et al.  Model for the retino-tectal projection , 1983, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[5]  W. Harris Homing behaviour of axons in the embryonic vertebrate brain , 1986, Nature.

[6]  J Walter,et al.  Recognition of position-specific properties of tectal cell membranes by retinal axons in vitro. , 1987, Development.

[7]  Thomas M. Jessell,et al.  Chemotropic guidance of developing axons in the mammalian central nervous system , 1988, Nature.

[8]  Jonathan A. Raper,et al.  The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain , 1990, Neuron.

[9]  J. Rothberg,et al.  slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. , 1990, Genes & development.

[10]  D. Hall,et al.  The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans , 1990, Neuron.

[11]  T. Jessell,et al.  Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant. , 1990, Development.

[12]  J. Culotti,et al.  UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans , 1992, Neuron.

[13]  A. Lumsden,et al.  Motor neuron pathfinding following rhombomere reversals in the chick embryo hindbrain. , 1992, Development.

[14]  C. Goodman,et al.  Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline , 1993, Neuron.

[15]  J. Culotti,et al.  Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally , 1993, Nature.

[16]  D. Raible,et al.  Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones , 1993, Cell.

[17]  Timothy E. Kennedy,et al.  Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord , 1994, Cell.

[18]  T. Jessell,et al.  The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6 , 1994, Cell.

[19]  Mu-ming Poo,et al.  Turning of nerve growth cones induced by neurotransmitters , 1994, Nature.

[20]  C. Holt,et al.  Chimeric Integrins Expressed in Retinal Ganglion Cells Impair Process Outgrowth in Vivo , 1995, Molecular and Cellular Neuroscience.

[21]  F. Murakami,et al.  Floor plate chemoattracts crossed axons and chemorepels uncrossed axons in the vertebrate brain , 1995, Neuron.

[22]  I. Shepherd,et al.  A family of molecules related to collapsin in the embryonic chick nervous system , 1995, Neuron.

[23]  M. Tessier-Lavigne,et al.  The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons , 1995, Cell.

[24]  Jinhong Fan,et al.  Localized collapsing cues can steer growth cones without inducing their full collapse , 1995, Neuron.

[25]  F. Murakami,et al.  Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis , 1995, Neuron.

[26]  C. Shatz,et al.  Sernaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord , 1995, Neuron.

[27]  Jürgen Löschinger,et al.  In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases , 1995, Cell.

[28]  John G Flanagan,et al.  Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo , 1996, Cell.

[29]  Jennifer L. Doyle,et al.  Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons , 1996, Neuron.

[30]  T. Pawson,et al.  Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System , 1996, Cell.

[31]  Y. Jan,et al.  frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance , 1996, Cell.

[32]  M. Masu,et al.  Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor , 1996, Cell.

[33]  T. Pawson,et al.  Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands , 1996, Nature.

[34]  C. Goodman,et al.  commissureless Controls Growth Cone Guidance across the CNS Midline in Drosophila and Encodes a Novel Membrane Protein , 1996, Neuron.

[35]  W. Harris,et al.  Engrailed, Retinotectal Targeting, and Axonal Patterning in the Midbrain during Xenopus Development: An Antisense Study , 1996, Neuron.

[36]  M. Seeger,et al.  Guidance Cues at the Drosophila CNS Midline: Identification and Characterization of Two Drosophila Netrin/UNC-6 Homologs , 1996, Neuron.

[37]  M. Tessier-Lavigne,et al.  Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III , 1997, Cell.

[38]  M. Lohrum,et al.  The chemorepulsive activity of secreted semaphorins is regulated by furin‐dependent proteolytic processing , 1997, The EMBO journal.

[39]  C. Goodman,et al.  Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III , 1997, Neuron.

[40]  Alex L Kolodkin,et al.  Neuropilin Is a Semaphorin III Receptor , 1997, Cell.

[41]  J. Raper,et al.  A Role for Collapsin-1 in Olfactory and Cranial Sensory Axon Guidance , 1997, The Journal of Neuroscience.

[42]  Jürgen Löschinger,et al.  Shared and distinct functions of RAGS and ELF‐1 in guiding retinal axons , 1997, The EMBO journal.

[43]  E. Pasquale,et al.  Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors , 1997, Science.

[44]  M. Masu,et al.  Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors , 1997, Nature.

[45]  Mu-ming Poo,et al.  cAMP-induced switching in turning direction of nerve growth cones , 1997, Nature.

[46]  T. Yagi,et al.  Disruption of Semaphorin III/D Gene Causes Severe Abnormality in Peripheral Nerve Projection , 1997, Neuron.

[47]  T. Yagi,et al.  Neuropilin–Semaphorin III/D-Mediated Chemorepulsive Signals Play a Crucial Role in Peripheral Nerve Projection in Mice , 1997, Neuron.

[48]  Hiroaki Kobayashi,et al.  A 70 Amino Acid Region within the Semaphorin Domain Activates Specific Cellular Response of Semaphorin Family Members , 1997, Neuron.

[49]  A. Varela-Echavarría,et al.  Motor Axon Subpopulations Respond Differentially to the Chemorepellents Netrin-1 and Semaphorin D , 1997, Neuron.

[50]  Stefan A. Przyborski,et al.  The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein , 1997, Nature.

[51]  Alex L Kolodkin,et al.  Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity , 1998, Neuron.

[52]  D. Van Vactor Adhesion and signaling in axonal fasciculation. , 1998, Current opinion in neurobiology.

[53]  C. Goodman,et al.  Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance , 1998, Cell.

[54]  C. Goodman,et al.  Semaphorins III and IV repel hippocampal axons via two distinct receptors. , 1998, Development.

[55]  R. Kalb,et al.  Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors , 1998, Nature Neuroscience.

[56]  Jonas Frisén,et al.  Ephrin-A5 (AL-1/RAGS) Is Essential for Proper Retinal Axon Guidance and Topographic Mapping in the Mammalian Visual System , 1998, Neuron.

[57]  Zhigang He,et al.  Semaphorin–Neuropilin Interactions Underlying Sympathetic Axon Responses to Class III Semaphorins , 1998, Neuron.

[58]  S. Sakano,et al.  Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. , 1998, Brain research. Molecular brain research.

[59]  F. Murakami,et al.  Change in chemoattractant responsiveness of developing axons at an intermediate target. , 1998, Science.

[60]  H. Kamiguchi,et al.  Role of L1 in Neural Development: What the Knockouts Tell Us , 1998, Molecular and Cellular Neuroscience.

[61]  M. Poo,et al.  Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. , 1998, Science.

[62]  Marc Tessier-Lavigne,et al.  Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors , 1998, Cell.

[63]  Mu-ming Poo,et al.  Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1 , 1999, Nature.

[64]  C. Goodman,et al.  Slit Is the Midline Repellent for the Robo Receptor in Drosophila , 1999, Cell.

[65]  John B. Thomas,et al.  Axon routing across the midline controlled by the Drosophila Derailed receptor , 1999, Nature.

[66]  J. Bixby,et al.  Receptor Tyrosine Phosphatase-δ Is a Homophilic, Neurite-Promoting Cell Adhesion Molecule for CNS Neurons , 1999, Molecular and Cellular Neuroscience.

[67]  L. Cox,et al.  Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. , 1999, Developmental biology.

[68]  Mu-ming Poo,et al.  A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion , 1999, Cell.

[69]  J. Bixby,et al.  Receptor tyrosine phosphatase-delta is a homophilic, neurite-promoting cell adhesion molecular for CNS neurons. , 1999, Molecular and cellular neurosciences.

[70]  R. Kalb,et al.  Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors , 1999, Cell.

[71]  Philippe Soriano,et al.  Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. , 1999, Genes & development.

[72]  J. Dodd,et al.  BMPs as Mediators of Roof Plate Repulsion of Commissural Neurons , 1999, Neuron.

[73]  C. Goodman,et al.  Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance , 1999, Cell.

[74]  Julie H. Simpson,et al.  Short-Range and Long-Range Guidance by Slit and Its Robo Receptors Robo and Robo2 Play Distinct Roles in Midline Guidance , 2000, Neuron.

[75]  Marc Tessier-Lavigne,et al.  Squeezing Axons Out of the Gray Matter A Role for Slit and Semaphorin Proteins from Midline and Ventral Spinal Cord , 2000, Cell.

[76]  M. Lohrum,et al.  Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A , 2000, Mechanisms of Development.

[77]  B. Dickson,et al.  Crossing the Midline Roles and Regulation of Robo Receptors , 2000, Neuron.

[78]  A. Hall,et al.  Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling , 2000, Cell.

[79]  Y. Zou,et al.  Neuropilin-2 Regulates the Development of Select Cranial and Sensory Nerves and Hippocampal Mossy Fiber Projections , 2000, Neuron.

[80]  Julie H. Simpson,et al.  Short-Range and Long-Range Guidance by Slit and Its Robo Receptors A Combinatorial Code of Robo Receptors Controls Lateral Position , 2000, Cell.

[81]  Anirvan Ghosh,et al.  Semaphorin 3A is a chemoattractant for cortical apical dendrites , 2000, Nature.

[82]  Jonathan A Raper,et al.  Semaphorins and their receptors in vertebrates and invertebrates , 2000, Current Opinion in Neurobiology.

[83]  R. Kalb,et al.  Molecular basis of semaphorin-mediated axon guidance. , 2000, Journal of neurobiology.

[84]  J. Bixby,et al.  Growth cone steering by receptor tyrosine phosphatase delta defines a distinct class of guidance cue. , 2000, Molecular and cellular neurosciences.

[85]  S. Rastan,et al.  Neuropilin-2 Is Required In Vivo for Selective Axon Guidance Responses to Secreted Semaphorins , 2000, Neuron.

[86]  Mu-ming Poo,et al.  Calcium signalling in the guidance of nerve growth by netrin-1 , 2000, Nature.

[87]  B. Dickson,et al.  Selecting a Longitudinal Pathway Robo Receptors Specify the Lateral Position of Axons in the Drosophila CNS , 2000, Cell.

[88]  J. C. Clemens,et al.  Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity , 2000, Cell.

[89]  J. Bixby,et al.  Growth Cone Steering by Receptor Tyrosine Phosphatase δ Defines a Distinct Class of Guidance Cue , 2000, Molecular and Cellular Neuroscience.

[90]  Neuronal Growth Cones , 2000 .

[91]  M. Schachner,et al.  Analysis of the L1-Deficient Mouse Phenotype Reveals Cross-Talk between Sema3A and L1 Signaling Pathways in Axonal Guidance , 2000, Neuron.

[92]  S. Robbins,et al.  Ephrin‐A5 modulates cell adhesion and morphology in an integrin‐dependent manner , 2000, The EMBO journal.

[93]  T. Jessell Neuronal specification in the spinal cord: inductive signals and transcriptional codes , 2000, Nature Reviews Genetics.

[94]  Hiroshi Takahashi,et al.  Axonal Growth from the Habenular Nucleus along the Neuromere Boundary Region of the Diencephalon Is Regulated by Semaphorin 3F and Netrin-1 , 2000, Molecular and Cellular Neuroscience.

[95]  M. Poo,et al.  Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates , 1999, Cell.

[96]  P. Bovolenta,et al.  Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. , 2001, Development.

[97]  M. Tessier-Lavigne,et al.  Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex , 2001, Science.

[98]  B. Dickson,et al.  Short- and Long-Range Repulsion by the Drosophila Unc5 Netrin Receptor , 2001, Neuron.

[99]  J. Huai,et al.  An ephrin-A-dependent Signaling Pathway Controls Integrin Function and Is Linked to the Tyrosine Phosphorylation of a 120-kDa Protein* , 2001, The Journal of Biological Chemistry.

[100]  M. Poo,et al.  Nerve growth cone guidance mediated by G protein–coupled receptors , 2002, Nature Neuroscience.

[101]  J. Lilien,et al.  Rhee, J. et al. Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion. Nat. Cell Biol. 4, 798-805 , 2002 .

[102]  O. Marín,et al.  Slit Proteins Prevent Midline Crossing and Determine the Dorsoventral Position of Major Axonal Pathways in the Mammalian Forebrain , 2002, Neuron.

[103]  D. O'Leary,et al.  EphB Forward Signaling Controls Directional Branch Extension and Arborization Required for Dorsal-Ventral Retinotopic Mapping , 2002, Neuron.

[104]  S. Pfaff,et al.  Transcriptional codes and the control of neuronal identity. , 2002, Annual review of neuroscience.

[105]  B. Dickson,et al.  Comm Sorts Robo to Control Axon Guidance at the Drosophila Midline , 2002, Cell.

[106]  G. Tear,et al.  Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline. , 2002, Development.

[107]  C. Holt,et al.  Topographic Mapping in Dorsoventral Axis of the Xenopus Retinotectal System Depends on Signaling through Ephrin-B Ligands , 2002, Neuron.

[108]  Carol A. Mason,et al.  Slit1 and Slit2 Cooperate to Prevent Premature Midline Crossing of Retinal Axons in the Mouse Visual System , 2002, Neuron.

[109]  A. Kolodkin,et al.  Semaphorin 3F Is Critical for Development of Limbic System Circuitry and Is Required in Neurons for Selective CNS Axon Guidance Events , 2003, The Journal of Neuroscience.

[110]  L. Richards,et al.  Slit2 Guides Both Precrossing and Postcrossing Callosal Axons at the Midline In Vivo , 2003, The Journal of Neuroscience.

[111]  Y. Rao,et al.  Signalling mechanisms mediating neuronal responses to guidance cues , 2003, Nature Reviews Neuroscience.

[112]  Sreekanth H. Chalasani,et al.  A Chemokine, SDF-1, Reduces the Effectiveness of Multiple Axonal Repellents and Is Required for Normal Axon Pathfinding , 2003, The Journal of Neuroscience.

[113]  John B. Thomas,et al.  Wnt-mediated axon guidance via the Drosophila Derailed receptor , 2003, Nature.

[114]  Marc Tessier-Lavigne,et al.  Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling , 2003, Science.

[115]  A. Kania,et al.  Topographic Motor Projections in the Limb Imposed by LIM Homeodomain Protein Regulation of Ephrin-A:EphA Interactions , 2003, Neuron.

[116]  M. Poo,et al.  Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning , 2003, Nature.

[117]  A. McMahon,et al.  The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance , 2003, Cell.

[118]  H. Fujisawa Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development. , 2004, Journal of neurobiology.

[119]  C. Goodman,et al.  Conserved Roles for Slit and Robo Proteins in Midline Commissural Axon Guidance , 2004, Neuron.

[120]  J. C. Clemens,et al.  Alternative Splicing of Drosophila Dscam Generates Axon Guidance Receptors that Exhibit Isoform-Specific Homophilic Binding , 2004, Cell.

[121]  F. Murakami,et al.  The Divergent Robo Family Protein Rig-1/Robo3 Is a Negative Regulator of Slit Responsiveness Required for Midline Crossing by Commissural Axons , 2004, Cell.

[122]  G. Rougon,et al.  Semaphorin3A-induced receptor endocytosis during axon guidance responses is mediated by L1 CAM , 2004, Molecular and Cellular Neuroscience.

[123]  Cornelia I. Bargmann,et al.  Inhibition of Netrin-Mediated Axon Attraction by a Receptor Protein Tyrosine Phosphatase , 2004, Science.

[124]  Mu-ming Poo,et al.  Guiding neuronal growth cones using Ca2+ signals. , 2004, Trends in cell biology.

[125]  C. Holt,et al.  Retinal axon guidance: novel mechanisms for steering , 2004, Current Opinion in Neurobiology.

[126]  C. Chien,et al.  When sugars guide axons: insights from heparan sulphate proteoglycan mutants , 2004, Nature Reviews Genetics.

[127]  Susann M Brady-Kalnay,et al.  Receptor protein tyrosine phosphatases regulate neural development and axon guidance. , 2004, Developmental biology.

[128]  T. Yanagida,et al.  Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis , 2005, The Journal of Neuroscience.

[129]  Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior Commissure , 2005, Neuron.

[130]  C. Holt,et al.  Endocytosis-dependent desensitization and protein synthesis–dependent resensitization in retinal growth cone adaptation , 2005, Nature Neuroscience.

[131]  K. Alitalo,et al.  Neural guidance molecules regulate vascular remodeling and vessel navigation. , 2005, Genes & development.

[132]  Mu-ming Poo,et al.  Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones , 2005, Nature.

[133]  Jun Shi,et al.  Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract , 2005, Nature Neuroscience.

[134]  Ning Li,et al.  Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor , 2005, Nature.

[135]  V. Pekarik,et al.  Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord , 2005, Nature Neuroscience.

[136]  Elena B. Pasquale,et al.  Eph receptor signalling casts a wide net on cell behaviour , 2005, Nature Reviews Molecular Cell Biology.

[137]  J. Sanes,et al.  Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior Commissure , 2005, Neuron.

[138]  D. Lipscombe Neuronal proteins custom designed by alternative splicing , 2005, Current Opinion in Neurobiology.

[139]  B. Dickson,et al.  Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo , 2005, Nature Neuroscience.

[140]  John G Flanagan,et al.  Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping , 2005, Nature Neuroscience.

[141]  C. Holt,et al.  The transcription factor Engrailed-2 guides retinal axons , 2005, Nature.

[142]  Ian D. Thompson,et al.  Opposing Gradients of Ephrin-As and EphA7 in the Superior Colliculus Are Essential for Topographic Mapping in the Mammalian Visual System , 2005, Neuron.

[143]  K. Aoki,et al.  FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain. , 2005, Brain research. Molecular brain research.

[144]  P. Worley,et al.  XTRPC1-dependent chemotropic guidance of neuronal growth cones , 2005, Nature Neuroscience.

[145]  A. Huberman,et al.  Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus , 2005, Nature Neuroscience.

[146]  P. Salinas,et al.  Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity , 2005, Nature Reviews Neuroscience.