Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage

[1]  K. Ma,et al.  Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model , 2022, Biomedicines.

[2]  G. Ingoglia,et al.  Hemolysis transforms liver macrophages into anti-inflammatory erythrophagocytes. , 2020, The Journal of clinical investigation.

[3]  F. Urano,et al.  Neuroplastin Modulates Anti-inflammatory Effects of MANF , 2020, iScience.

[4]  Shin-Yuan Chen,et al.  A Role for Endoplasmic Reticulum Stress in Intracerebral Hemorrhage , 2020, Cells.

[5]  M. Saarma,et al.  Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice , 2019, Neurobiology of Disease.

[6]  Cheng-Yoong Pang,et al.  Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats , 2019, Cells.

[7]  D. Holtzman,et al.  Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model , 2019, The Journal of experimental medicine.

[8]  M. T. Pellecchia,et al.  PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts , 2019, Front. Neurosci..

[9]  M. Saarma,et al.  CDNF Protein Therapy in Parkinson’s Disease , 2019, Cell transplantation.

[10]  M. Airavaara,et al.  Neuroprotective and reparative effects of endoplasmic reticulum luminal proteins – mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor , 2019, Croatian medical journal.

[11]  H. Jasper,et al.  Trophic Factors in Inflammation and Regeneration: The Role of MANF and CDNF , 2018, Front. Physiol..

[12]  P. Zamorano,et al.  CDNF induces the adaptive unfolded protein response and attenuates endoplasmic reticulum stress-induced cell death. , 2018, Biochimica et biophysica acta. Molecular cell research.

[13]  Minoru Kanehisa,et al.  New approach for understanding genome variations in KEGG , 2018, Nucleic Acids Res..

[14]  Qianqian Li,et al.  Research Progress in Understanding the Relationship Between Heme Oxygenase-1 and Intracerebral Hemorrhage , 2018, Front. Neurol..

[15]  Xiao-Jing Wang,et al.  Cerebral Dopamine Neurotrophic Factor (CDNF) Has Neuroprotective Effects against Cerebral Ischemia That May Occur through the Endoplasmic Reticulum Stress Pathway , 2018, International journal of molecular sciences.

[16]  S. Blackburn,et al.  Haemoglobin scavenging in intracranial bleeding: biology and clinical implications , 2018, Nature Reviews Neurology.

[17]  Olli-Pekka Smolander,et al.  Poststroke delivery of MANF promotes functional recovery in rats , 2018, Science Advances.

[18]  Xinwen Zhou,et al.  Endoplasmic reticulum stress induces spatial memory deficits by activating GSK‐3 , 2018, Journal of cellular and molecular medicine.

[19]  M. Maes,et al.  The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications , 2018, Molecular Neurobiology.

[20]  F. Safadi,et al.  The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor , 2018, Journal of Neuroinflammation.

[21]  L. Watkins,et al.  Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury , 2018, eNeuro.

[22]  Jiping Tang,et al.  Haematoma scavenging in intracerebral haemorrhage: from mechanisms to the clinic , 2017, Journal of cellular and molecular medicine.

[23]  Hui Sun,et al.  Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway , 2017, Experimental Gerontology.

[24]  S. Mayer,et al.  Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2017, Stroke.

[25]  B. Barres,et al.  Microglia and macrophages in brain homeostasis and disease , 2017, Nature Reviews Immunology.

[26]  A. Regev,et al.  Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution , 2017, Cell reports.

[27]  K. Khodosevich,et al.  MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[28]  J. Aronowski,et al.  Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage , 2017, Nature Communications.

[29]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[30]  Xiaoning Han,et al.  Modulators of microglial activation and polarization after intracerebral haemorrhage , 2017, Nature Reviews Neurology.

[31]  Qingwu Yang,et al.  Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage , 2016, Molecular Neurobiology.

[32]  M. Saarma,et al.  Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra , 2017, eNeuro.

[33]  Jiping Qi,et al.  Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[34]  B. Stoica,et al.  Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury. , 2016, Journal of neurotrauma.

[35]  Qun Liu,et al.  CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage , 2016, Neural regeneration research.

[36]  Charles C. Kim,et al.  Brain trauma elicits non-canonical macrophage activation states , 2016, Journal of Neuroinflammation.

[37]  A. Józkowicz,et al.  Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism , 2016, Cellular and Molecular Life Sciences.

[38]  H. Bae,et al.  Spontaneous Intracerebral Hemorrhage: Management , 2016, Journal of stroke.

[39]  C. Ogilvy,et al.  Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. , 2015, The Journal of clinical investigation.

[40]  J. Aronowski,et al.  Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance , 2015, Journal of neurochemistry.

[41]  R. Veltkamp,et al.  Neuroinflammation after intracerebral hemorrhage , 2014, Front. Cell. Neurosci..

[42]  Palaniyandi Ravanan,et al.  A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress , 2014, Front. Cell. Neurosci..

[43]  L. Nie,et al.  Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia , 2014, Journal of Molecular Neuroscience.

[44]  L. Nie,et al.  Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia , 2013, Journal of Molecular Neuroscience.

[45]  W. Scheper,et al.  Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation , 2013, Neurobiology of Aging.

[46]  V. Perry,et al.  Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration , 2013, Seminars in Immunopathology.

[47]  P. Rada,et al.  Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity , 2013, Cell Death and Disease.

[48]  H. Schluesener,et al.  Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury , 2013, Neuroreport.

[49]  J. Kuo,et al.  Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats , 2012, Journal of Neuroinflammation.

[50]  J. Aronowski,et al.  Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. , 2011, Stroke.

[51]  Hsin-Yi Huang,et al.  Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades , 2010, Journal of Neuroinflammation.

[52]  M. Saarma,et al.  Novel CDNF/MANF family of neurotrophic factors , 2010, Developmental neurobiology.

[53]  J. Grotta,et al.  Hematoma resolution as a therapeutic target: the role of microglia/macrophages. , 2009, Stroke.

[54]  J. Diehl,et al.  Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival , 2008, Journal of Biological Chemistry.

[55]  M. Saarma,et al.  Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo , 2007, Nature.

[56]  Abhinav K. Jain,et al.  GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. , 2007, The Journal of biological chemistry.

[57]  J. Grotta,et al.  Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator‐activated receptor γ in microglia/macrophages , 2007, Annals of neurology.

[58]  S. Moestrup,et al.  CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response , 2004, Annals of medicine.

[59]  Randal J. Kaufman,et al.  Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival , 2003, Molecular and Cellular Biology.

[60]  J. Loike,et al.  Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system , 2002, Glia.

[61]  J. Broderick,et al.  Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. , 1998, Stroke.

[62]  J. Kuo,et al.  Therapeutic benefit of urocortin in rats with intracerebral hemorrhage. , 2012, Journal of neurosurgery.