Outstanding research opportunities at the interface of evolution and medicine

Evolutionary medicine is a research frontier whose promise has only partially been realized. Here I discuss the advances that have built its foundation and point to where progress is most needed.

[1]  P. Gluckman,et al.  Early developmental conditioning of later health and disease: physiology or pathophysiology? , 2014, Physiological reviews.

[2]  M. Cecchini,et al.  Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease , 2016, Scientific Reports.

[3]  Holly M. Mortensen,et al.  Convergent adaptation of human lactase persistence in Africa and Europe , 2007, Nature Genetics.

[4]  Vincent J. Lynch,et al.  Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals , 2011, Nature Genetics.

[5]  C. Kuzawa,et al.  Developmental Origins of Adult Function and Health: Evolutionary Hypotheses , 2009 .

[6]  Urs A Meyer,et al.  Omics and drug response. , 2013, Annual review of pharmacology and toxicology.

[7]  M. Inouye,et al.  Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy , 2016, bioRxiv.

[8]  G. Wagner,et al.  The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal invasiveness. , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[9]  S. Stearns,et al.  Natural selection in a contemporary human population , 2010, Proceedings of the National Academy of Sciences.

[10]  A. Hill.  Evolution, revolution and heresy in the genetics of infectious disease susceptibility , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

[11]  Andy Gardner,et al.  Frequency Dependence and Cooperation: Theory and a Test with Bacteria , 2007, The American Naturalist.

[12]  Stephen P. Diggle,et al.  Targeting virulence: can we make evolution-proof drugs? , 2014, Nature Reviews Microbiology.

[13]  D. Haig.  Genomic imprinting and kinship: how good is the evidence? , 2004, Annual review of genetics.

[14]  Gavin J. D. Smith,et al.  Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic , 2009, Nature.

[15]  Atila Iamarino,et al.  Early and multiple origins of metastatic lineages within primary tumors , 2016, Proceedings of the National Academy of Sciences.

[16]  Troy Day,et al.  The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy , 2011, Proceedings of the National Academy of Sciences.

[17]  P. Sharp,et al.  The evolution of HIV-1 and the origin of AIDS , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[18]  Yan Sun,et al.  Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality , 2016, Scientific Reports.