The Effects of Air Pollutants on the Prevalence of Common Ear, Nose, and Throat Diseases in South Korea: A National Population-Based Study

Objectives The effects of air pollutants on upper airway disease development have been seldom studied. In this study, we evaluated the effects of air pollution on the prevalence of ENT diseases. Methods We identified cases of ENT disease occurring in 2009, as recorded by the Korea National Health and Nutrition Examination Survey, and explored their associations with the levels of five air pollutants: sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), carbon monoxide (CO), and particulate matter (PM10 particles; particulates ≤10 μm in aerodynamic diameter). Subjects diagnosed with at least one of the five studied ENT diseases were included in analysis, but those aged under 19 years were excluded. Linear associations between ENT disease frequency and pollutant levels were evaluated by calculating Spearman correlations. After adjusting for age, gender, and geographic region, multivariate logistic regression was used to obtain odds ratios (OR) with 95% confidence intervals (CI). Results A total of 7,399 subjects with ENT diseases were identified. A linear association was evident between PM10 concentration and the frequency of septal deviation (Spearman coefficient, 0.507; P=0.045). After adjustment, the PM10 level was associated with high odds ratios for chronic rhinosinusitis (1.22; 95% CI, 1.02 to 1.46) and septal deviation (1.43; 95% CI, 1.22 to 1.67). Both of these conditions were more prevalent in males. Conclusion We found that increased ambient concentrations of PM10 particles were clearly associated with increased the risk of chronic rhinosinusitis and septal deviation; the exposure-response relationship was definitive.

[1]  Changsoo Kim,et al.  Short-term Effects of Ambient Air Pollution on Emergency Department Visits for Asthma: An Assessment of Effect Modification by Prior Allergic Disease History , 2016, Journal of preventive medicine and public health = Yebang Uihakhoe chi.

[2]  P. Andrades,et al.  The accuracy of different methods for diagnosing septal deviation in patients undergoing septorhinoplasty: A prospective study. , 2016, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[3]  S. Yi,et al.  Ambient air pollution and out-of-hospital cardiac arrest. , 2016, International journal of cardiology.

[4]  Murugappan Ramanathan,et al.  The Role of Innate Immunity and Aeroallergens in Chronic Rhinosinusitis. , 2016, Advances in oto-rhino-laryngology.

[5]  Li Wang,et al.  Ambient air quality and the effects of air pollutants on otolaryngology in Beijing , 2015, Environmental Monitoring and Assessment.

[6]  Paolo Vineis,et al.  Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis , 2014, Environmental health perspectives.

[7]  Angela Maria Magosso Takayanagui,et al.  Poluição do ar e doenças respiratórias alérgicas em escolares , 2014 .

[8]  Â. M. Takayanagui,et al.  Air pollution and respiratory allergic diseases in schoolchildren , 2014, Revista de saude publica.

[9]  M. Cunningham,et al.  Clinical assessment is an accurate predictor of which patients will need septoplasty , 2013, The Laryngoscope.

[10]  Lei Zhou,et al.  The lag effects and seasonal differences of air pollutants on allergic rhinitis in Beijing. , 2013, The Science of the total environment.

[11]  Fengying Zhang,et al.  Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China. , 2011, The Science of the total environment.

[12]  Heung-Man Lee,et al.  Diagnostic Accuracy Evaluation of Nasal Sound Spectral Analysis Compared with Peak Nasal Inspiratory Flow in Nasal Septal Deviation , 2011, American journal of rhinology & allergy.

[13]  A. Nusrat,et al.  Epithelial tight junction alterations in nasal polyposis , 2011, International forum of allergy & rhinology.

[14]  J. Clougherty,et al.  A Growing Role for Gender Analysis in Air Pollution Epidemiology , 2009, Environmental health perspectives.

[15]  R. Doty,et al.  Urban air pollution: influences on olfactory function and pathology in exposed children and young adults. , 2010, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[16]  D. Postma,et al.  Air pollution and development of asthma, allergy and infections in a birth cohort , 2007, European Respiratory Journal.

[17]  J. Schwartz,et al.  Individual-level modifiers of the effects of particulate matter on daily mortality. , 2006, American journal of epidemiology.

[18]  Bert Brunekreef,et al.  Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. , 2002, American journal of respiratory and critical care medicine.

[19]  Yun-Chul Hong,et al.  Air Pollution: A New Risk Factor in Ischemic Stroke Mortality , 2002, Stroke.

[20]  J V West,et al.  Acute upper airway infections , 2002, British medical bulletin.

[21]  T. van Dyke,et al.  Nasal Biopsies of Children Exposed to Air Pollutants , 2001, Toxicologic pathology.

[22]  R. Devlin,et al.  Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. , 2001, American journal of respiratory cell and molecular biology.

[23]  J. Corey,et al.  Acoustic Rhinometry and Computed Tomography Scans for the Diagnosis of Nasal Septal Deviation, With Clinical Correlation , 2000, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[24]  P. Kinney,et al.  Long-term residence in areas of high ozone: associations with respiratory health in a nationwide sample of nonsmoking young adults [dsee comments] , 1999, Environmental health perspectives.

[25]  L. Calderón-Garcidueñas,et al.  Cell proliferation in nasal respiratory epithelium of people exposed to urban pollution. , 1999, Carcinogenesis.

[26]  G. Allen,et al.  Particulate matter, sulfur dioxide, and pulmonary function in never-smoking adults in Chongqing, China. , 1999, International journal of occupational and environmental health.

[27]  L. Calderón-Garcidueñas,et al.  Nasal epithelium as a sentinel for airborne environmental pollution. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[28]  P. Clement,et al.  Acoustic Rhinometry and Rhinomanometry in the Evaluation of Nasal Patency of Patients with Nasal Septal Deviation , 1998, American journal of rhinology.

[29]  P. Enright,et al.  Long-term particulate and other air pollutants and lung function in nonsmokers. , 1998, American journal of respiratory and critical care medicine.

[30]  G A Allen,et al.  Effects of ozone and other pollutants on the pulmonary function of adult hikers. , 1998, Environmental health perspectives.

[31]  U Ackermann-Liebrich,et al.  Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. , 1997, American journal of respiratory and critical care medicine.

[32]  E Lebret,et al.  Chronic respiratory symptoms in children and adults living along streets with high traffic density. , 1996, Occupational and environmental medicine.

[33]  D A Savitz,et al.  Pulmonary function and ambient particulate matter: epidemiological evidence from NHANES I. , 1991, Archives of environmental health.

[34]  W Jedrychowski,et al.  Ventilatory lung function and chronic chest symptoms among the inhabitants of urban areas with various levels of acid aerosols: prospective study in Cracow. , 1989, Environmental health perspectives.

[35]  E. Weeke,et al.  Allergic Rhinitis in Danish General Practice , 1981, Allergy.