论文信息 - HAPLOT: a graphical comparison of haplotype blocks, tagSNP sets and SNP variation for multiple populations

HAPLOT: a graphical comparison of haplotype blocks, tagSNP sets and SNP variation for multiple populations

UNLABELLED Understanding of human variation relevant to association studies can benefit from population comparison, especially comparing populations in the same geographical region. Variations in linkage disequilibrium patterns, in tagSNP sets, and in SNP heterozygosities among populations can be used to infer the evolutionary pattern. We present here a win32 system based Perl/Tk application for visual comparisons of these variations in different populations. AVAILABILITY The application package is available at http://info.med.yale.edu/genetics/kkidd/programs.html CONTACT sheng.gu@yale.edu.

[1] C. Carlson,et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. , 2004, American journal of human genetics.

[2] M. Waterman,et al. A dynamic programming algorithm for haplotype block partitioning , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[3] S. Gabriel,et al. The Structure of Haplotype Blocks in the Human Genome , 2002, Science.

[4] K K Kidd,et al. PhenoDB: an integrated client/server database for linkage and population genetics. , 1996, Computers and biomedical research, an international journal.

[5] Toshihiro Tanaka. The International HapMap Project , 2003, Nature.

[6] P. Tam. The International HapMap Consortium. The International HapMap Project (Co-PI of Hong Kong Centre which responsible for 2.5% of genome) , 2003 .

[7] Hongyu Zhao,et al. Haplotype block structures show significant variation among populations , 2004, Genetic epidemiology.

[8] K. Rohde,et al. Entropy as a Measure for Linkage Disequilibrium over Multilocus Haplotype Blocks , 2003, Human Heredity.

[9] Kui Zhang,et al. Hapblock: Haplotype Block Partitioning and Tag Snp Selection Software Using a Set of Dynamic Programming Algorithms , 2022 .

[10] Mark Daly,et al. Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..