Three-dimensional self-assembly of structures using the pressure due to a ferrofluid in a magnetic field gradient

We developed an inexpensive and simple system for three-dimensional self-assembly of micron-sized nonmagnetic particles into millimeter-scale structures using the differential pressure exerted by ferrofluids in the presence of magnetic field gradients. We demonstrate it by assembling separate individual 5, 10, and 21μm diam polystyrene beads into millimeter-sized spherical and ellipsoidal structures. The system can also self-organize its smaller components by volume and provide compressive forces of hundreds of piconewtons on millimeter-scale structures. Extensions of this method have assembled multicellular systems.

[1]  George M. Whitesides,et al.  Making Things by Self-Assembly , 2005 .

[2]  Roberto Kolter,et al.  Biofilms: the matrix revisited. , 2005, Trends in microbiology.

[3]  B. Bassler,et al.  Bacterial social engagements. , 2004, Trends in cell biology.

[4]  G. Whitesides,et al.  A magnetic trap for living cells suspended in a paramagnetic buffer , 2004 .

[5]  J. Cernák,et al.  Aggregation dynamics of nonmagnetic particles in a ferrofluid. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[6]  T. Lubensky,et al.  Field-induced structures in miscible ferrofluid suspensions with and without latex spheres. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[7]  D. Ingber Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. , 2002, Circulation research.

[8]  George M. Whitesides,et al.  Beyond molecules: Self-assembly of mesoscopic and macroscopic components , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  G. Whitesides,et al.  Self-Assembly at All Scales , 2002, Science.

[10]  H. Watarai,et al.  Magnetophoretic Behavior of Single Polystyrene Particles in Aqueous Manganese(II) Chloride , 2001, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[11]  A. Skjeltorp Ordering phenomena of particles dispersed in magnetic fluids (invited) , 1985 .