Dopamine carbon nanodots as effective photothermal agents for cancer therapy

Dopamine carbon nanodots (DA CNDs) with an average diameter of approximately 23 nm were prepared through a facile hydrothermal method without adding any passivating agents. The as-prepared DA CNDs have high photothermal conversion efficiency (35%), excellent photostability and thermal stability. More importantly, DA CNDs exhibit significant photothermal therapeutic effects toward human cervical cancer (HeLa) cells under laser irradiation, while no appreciable dark cytotoxicity was observed even in high concentrations of DA CNDs aqueous solution. These results indicate that DA CNDs possess great potential to be effective photothermal agents for cancer therapy.

[1]  M. Jaroniec,et al.  Triconstituent co-assembly synthesis of N,S-doped carbon–silica nanospheres with smooth and rough surfaces , 2016 .

[2]  He Shen,et al.  Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO2 nanocomposites , 2016 .

[3]  Jiechao Ge,et al.  Tunable multicolor carbon dots prepared from well-defined polythiophene derivatives and their emission mechanism. , 2016, Nanoscale.

[4]  X. Jing,et al.  Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents. , 2015, Colloids and surfaces. B, Biointerfaces.

[5]  Dan Qu,et al.  Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells. , 2015, ACS nano.

[6]  Zhigang Xie,et al.  One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer. , 2015, ACS applied materials & interfaces.

[7]  X. Jing,et al.  Small molecular nanomedicines made from a camptothecin dimer containing a disulfide bond , 2015 .

[8]  M. Jaroniec,et al.  Molecular-based design and emerging applications of nanoporous carbon spheres. , 2015, Nature materials.

[9]  X. Jing,et al.  Biodegradable dextran vesicles for effective haemoglobin encapsulation. , 2015, Journal of materials chemistry. B.

[10]  Pengfei Wang,et al.  Red‐Emissive Carbon Dots for Fluorescent, Photoacoustic, and Thermal Theranostics in Living Mice , 2015, Advanced materials.

[11]  Bai Yang,et al.  Investigation from chemical structure to photoluminescent mechanism: a type of carbon dots from the pyrolysis of citric acid and an amine , 2015 .

[12]  N. Thakor,et al.  Biocompatible conjugated polymer nanoparticles for efficient photothermal tumor therapy. , 2015, Small.

[13]  M. Fourmigué,et al.  Water-soluble nickel-bis(dithiolene) complexes as photothermal agents. , 2015, Chemical communications.

[14]  Jin Ho Chang,et al.  Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging. , 2015, ACS nano.

[15]  X. Qu,et al.  Tumor Microenvironment Activated Photothermal Strategy for Precisely Controlled Ablation of Solid Tumors upon NIR Irradiation , 2015 .

[16]  X. Jing,et al.  Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate. , 2015, ACS medicinal chemistry letters.

[17]  X. Qu,et al.  A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy. , 2014, Biomaterials.

[18]  X. Jing,et al.  Paclitaxel prodrug nanoparticles combining chemical conjugation and physical entrapment for enhanced antitumor efficacy , 2014 .

[19]  Chun‐Sing Lee,et al.  A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation , 2014, Nature Communications.

[20]  X. Jing,et al.  Synthesis of cross-linked polymers via multi-component Passerini reaction and their application as efficient photocatalysts , 2014 .

[21]  X. Jing,et al.  Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine , 2014, Advanced materials.

[22]  X. Jing,et al.  On-off-on fluorescent carbon dot nanosensor for recognition of chromium(VI) and ascorbic acid based on the inner filter effect. , 2013, ACS applied materials & interfaces.

[23]  Fuyou Li,et al.  NIR photothermal therapy using polyaniline nanoparticles. , 2013, Biomaterials.

[24]  Dan Qu,et al.  Highly luminescent S, N co-doped graphene quantum dots with broad visible absorption bands for visible light photocatalysts. , 2013, Nanoscale.

[25]  Xiaogang Qu,et al.  Hydrophobic Anticancer Drug Delivery by a 980 nm Laser‐Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo , 2013, Advanced materials.

[26]  Ping Gong,et al.  Indocyanine Green Nanoparticles for Theranostic Applications , 2013 .

[27]  R. Mezzenga,et al.  Tunable Carbon Nanotube/Protein Core‐Shell Nanoparticles with NIR‐ and Enzymatic‐Responsive Cytotoxicity , 2013, Advanced materials.

[28]  Kai Yang,et al.  Nano-graphene in biomedicine: theranostic applications. , 2013, Chemical Society reviews.

[29]  Jianhua Hao,et al.  Deep ultraviolet photoluminescence of water-soluble self-passivated graphene quantum dots. , 2012, ACS nano.

[30]  Kai Yang,et al.  In vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene. , 2012, ACS nano.

[31]  Zhen Fan,et al.  Nanomaterials for targeted detection and photothermal killing of bacteria. , 2012, Chemical Society reviews.

[32]  N. Khlebtsov,et al.  Gold nanoparticles in biomedical applications: recent advances and perspectives. , 2012, Chemical Society reviews.

[33]  B. K. Gupta,et al.  Graphene quantum dots derived from carbon fibers. , 2012, Nano letters.

[34]  Rujia Zou,et al.  Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. , 2011, ACS nano.

[35]  Meifang Zhu,et al.  Hydrophilic Flower‐Like CuS Superstructures as an Efficient 980 nm Laser‐Driven Photothermal Agent for Ablation of Cancer Cells , 2011, Advanced materials.

[36]  D. Zhao,et al.  Extension of the Stöber method to the preparation of monodisperse resorcinol-formaldehyde resin polymer and carbon spheres. , 2011, Angewandte Chemie.

[37]  Matthew G. Panthani,et al.  Copper selenide nanocrystals for photothermal therapy. , 2011, Nano letters.

[38]  H. Dai,et al.  Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. , 2011, Journal of the American Chemical Society.

[39]  Sheila N. Baker,et al.  Luminescent carbon nanodots: emergent nanolights. , 2010, Angewandte Chemie.

[40]  Kai Yang,et al.  Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. , 2010, Nano letters.

[41]  Hyeonseok Yoon,et al.  Kinetic study of the formation of polypyrrole nanoparticles in water-soluble polymer/metal cation systems: a light-scattering analysis. , 2010, Small.

[42]  Minghong Wu,et al.  Hydrothermal Route for Cutting Graphene Sheets into Blue‐Luminescent Graphene Quantum Dots , 2010, Advanced materials.

[43]  J. Jang,et al.  Size control of magnetic carbon nanoparticles for drug delivery. , 2010, Biomaterials.

[44]  John M. Fonner,et al.  Biocompatibility implications of polypyrrole synthesis techniques , 2008, Biomedical materials.

[45]  J. West,et al.  Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. , 2007, Nano letters.

[46]  Anna C. Balazs,et al.  Nanoparticle Polymer Composites: Where Two Small Worlds Meet , 2006, Science.

[47]  Paul M. George,et al.  Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics. , 2005, Biomaterials.

[48]  A. Vogel,et al.  Mechanisms of pulsed laser ablation of biological tissues. , 2003, Chemical reviews.

[49]  S. Torp-Pedersen,et al.  Interstitial hyperthermia of colorectal liver metastases with a US-guided Nd-YAG laser with a diffuser tip: a pilot clinical study. , 1993, Radiology.

[50]  Kai Yang,et al.  VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo. , 2015, Biomaterials.