Cellular mechanisms of pattern formation in the developing limb.

Publisher Summary This chapter describes limb development in the chick wing emphasizing the musculature and skeletal pattern. The chapter discusses the sequence of events during early limb development and limb outgrowth. The pattern formation along the different axes of the limb and the importance of specialized regions in the wing are discussed in the chapter. The chapter examines the process of cell differentiation and reviews several theoretical models that have been proposed to account for limb development. Limb development consists of a series of sequential processes. A limb site is determined, polarity is established, and outgrowth ensues. As the limb elongates, the skeletal pattern appears in a proximodistal sequence. The stabilization of each element follows after a period in which cell determination is labile and may be influenced by external factors. Pattern development in the limb is a highly intricate process involving cell–cell, cell–tissue, and tissue–tissue interactions that change with time and position in a complicated three-dimensional geometry, which also changes with time.

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