The present view of the mechanism of protein folding

[1]  Pier Paolo Di Fiore,et al.  Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation , 2003, Nature Cell Biology.

[2]  Valerie Daggett,et al.  The molecular basis for the chemical denaturation of proteins by urea , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Valerie Daggett,et al.  The complete folding pathway of a protein from nanoseconds to microseconds , 2003, Nature.

[4]  A. Matouschek Protein unfolding--an important process in vivo? , 2003, Current opinion in structural biology.

[5]  T. Kiefhaber,et al.  Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding. , 2003, Journal of molecular biology.

[6]  M. Karplus,et al.  Self-consistent determination of the transition state for protein folding: Application to a fibronectin type III domain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Fersht,et al.  Is there a unifying mechanism for protein folding? , 2003, Trends in biochemical sciences.

[8]  S. Emr,et al.  Receptor downregulation and multivesicular-body sorting , 2002, Nature Reviews Molecular Cell Biology.

[9]  T. Sosnick,et al.  Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding. , 2002, Journal of molecular biology.

[10]  M. Karplus,et al.  Determination of a transition state at atomic resolution from protein engineering data. , 2002, Journal of molecular biology.

[11]  V. Pande,et al.  Absolute comparison of simulated and experimental protein-folding dynamics , 2002, Nature.

[12]  A. Fersht On the simulation of protein folding by short time scale molecular dynamics and distributed computing , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Jane Clarke,et al.  Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering. , 2002, Journal of molecular biology.

[14]  V. Daggett,et al.  Increasing temperature accelerates protein unfolding without changing the pathway of unfolding. , 2002, Journal of molecular biology.

[15]  Christopher M. Dobson,et al.  Protein-misfolding diseases: Getting out of shape , 2002, Nature.

[16]  B. Bowler,et al.  Effects of topology and excluded volume on protein denatured state conformational properties. , 2002, Biochemistry.

[17]  H. Roder,et al.  Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[18]  S. Radford,et al.  The effect of core destabilization on the mechanical resistance of I27. , 2002, Biophysical journal.

[19]  J. W. Kelly Towards an understanding of amyloidogenesis , 2002, Nature Structural Biology.

[20]  Kevin W Plaxco,et al.  How the folding rate constant of simple, single-domain proteins depends on the number of native contacts , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[21]  A. Fersht,et al.  Protein Folding and Unfolding at Atomic Resolution , 2002, Cell.

[22]  S. Marqusee,et al.  Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H. , 2002, Journal of molecular biology.

[23]  H. Pelham,et al.  A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies , 2002, Nature Cell Biology.

[24]  R. L. Baldwin A new perspective on unfolded proteins. , 2002, Advances in protein chemistry.

[25]  D. Shortle The expanded denatured state: an ensemble of conformations trapped in a locally encoded topological space. , 2002, Advances in protein chemistry.

[26]  T. Kohout,et al.  Regulation of Receptor Fate by Ubiquitination of Activated β2-Adrenergic Receptor and β-Arrestin , 2001, Science.

[27]  Fulvio Reggiori,et al.  Sorting of proteins into multivesicular bodies: ubiquitin‐dependent and ‐independent targeting , 2001, The EMBO journal.

[28]  L. Hicke A New Ticket for Entry into Budding Vesicles—Ubiquitin , 2001, Cell.

[29]  S. Emr,et al.  Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I , 2001, Cell.

[30]  L. Hicke,et al.  Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis* , 2001, The Journal of Biological Chemistry.

[31]  L. Serrano,et al.  NMR and SAXS characterization of the denatured state of the chemotactic protein Che Y: Implications for protein folding initiation , 2001, Protein science : a publication of the Protein Society.

[32]  J. Clarke,et al.  Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state. , 2001, Structure.

[33]  J. Forman-Kay,et al.  Solution structure of a Nedd4 WW domain–ENaC peptide complex , 2001, Nature Structural Biology.

[34]  Valerie Daggett,et al.  Protein folding from a highly disordered denatured state: The folding pathway of chymotrypsin inhibitor 2 at atomic resolution , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  K. Schulten,et al.  The key event in force-induced unfolding of Titin's immunoglobulin domains. , 2000, Biophysical journal.

[36]  D Baker,et al.  Long-range order in the src SH3 folding transition state. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M Karplus,et al.  Unfolding proteins by external forces and temperature: the importance of topology and energetics. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[38]  L Serrano,et al.  Similarities between the spectrin SH3 domain denatured state and its folding transition state. , 2000, Journal of molecular biology.

[39]  C. J. Bond,et al.  Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding. , 2000, Journal of molecular biology.

[40]  A. Fersht,et al.  Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[41]  L. Hicke,et al.  Monoubiquitin carries a novel internalization signal that is appended to activated receptors , 2000, The EMBO journal.

[42]  D. Bowtell,et al.  The Cbl protooncoprotein stimulates CSF‐1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation , 1999, The EMBO journal.

[43]  H. Hama,et al.  Vps9p Is a Guanine Nucleotide Exchange Factor Involved in Vesicle-mediated Vacuolar Protein Transport* , 1999, The Journal of Biological Chemistry.

[44]  J. Clarke,et al.  Mechanical and chemical unfolding of a single protein: a comparison. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[45]  L. Hicke Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels. , 1999, Trends in cell biology.

[46]  L Serrano,et al.  High populations of non-native structures in the denatured state are compatible with the formation of the native folded state. , 1998, Journal of molecular biology.

[47]  Valerie Daggett,et al.  Combined Molecular Dynamics and Φ-Value Analysis of Structure−Reactivity Relationships in the Transition State and Unfolding Pathway of Barnase: Structural Basis of Hammond and Anti-Hammond Effects , 1998 .

[48]  P. Kollman,et al.  Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution. , 1998, Science.

[49]  S. Kazmirski,et al.  Simulations of the structural and dynamical properties of denatured proteins: the "molten coil" state of bovine pancreatic trypsin inhibitor. , 1998, Journal of molecular biology.

[50]  A. Li,et al.  Molecular dynamics simulation of the unfolding of barnase , 1998 .

[51]  L. Hicke,et al.  A function for monoubiquitination in the internalization of a G protein-coupled receptor. , 1998, Molecular cell.

[52]  M Karplus,et al.  "New view" of protein folding reconciled with the old through multiple unfolding simulations. , 1997, Science.

[53]  C. J. Bond,et al.  Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[54]  Marino Zerial,et al.  A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function , 1997, Cell.

[55]  A. Ciechanover,et al.  The ubiquitin conjugation system is required for ligand‐induced endocytosis and degradation of the growth hormone receptor. , 1996, The EMBO journal.

[56]  A. Fersht,et al.  Structure of the transition state for folding of a protein derived from experiment and simulation. , 1996, Journal of molecular biology.

[57]  M. Hochstrasser Ubiquitin-dependent protein degradation. , 1996, Annual review of genetics.

[58]  A. Li,et al.  Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[59]  G L Gilliland,et al.  Structural studies of the engrailed homeodomain , 1994, Protein science : a publication of the Protein Society.

[60]  A. Fersht,et al.  Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[61]  A. Fersht,et al.  The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding. , 1992, Journal of molecular biology.

[62]  C. Dobson Unfolded proteins, compact states and molten globules: Current Opinion in Structural Biology 1992, 2:6–12 , 1992 .

[63]  Christopher M. Dobson Unfolded proteins, compact states and molten globules , 1992, Current Biology.

[64]  Alan R. Fersht,et al.  Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy , 1991 .

[65]  Conrad C. Huang,et al.  The MIDAS display system , 1988 .

[66]  O. Ptitsyn Protein folding: Hypotheses and experiments , 1987 .

[67]  P. S. Kim,et al.  Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding. , 1982, Annual review of biochemistry.

[68]  M. Karplus,et al.  Protein-folding dynamics , 1976, Nature.

[69]  N H Martin,et al.  Men and machines. , 1973, Journal of clinical pathology.

[70]  D. Wetlaufer Nucleation, rapid folding, and globular intrachain regions in proteins. , 1973, Proceedings of the National Academy of Sciences of the United States of America.