Clinical Trials of Inhaled Nitric Oxide Therapy in the Newborn

1. Describe the benefits of inhaled nitric oxide in the treatment of persistent pulmonary hypertension of the newborn. 2. Determine the range of appropriate initial doses of inhaled nitric oxide therapy for term neonates. 3. Delineate the potential role of inhaled nitric oxide in conjunction with extracorporeal membrane oxygenation. 4. Describe the lung-specific effects of low-dose inhaled nitric oxide therapy in preterm newborns who have severe hypoxemic respiratory failure.