Delayed maturation of the frontal cortex in childhood autism.

OBJECTIVE The authors investigated the metabolic maturation of the frontal cortex in pre-school autistic children. METHOD Regional cerebral blood flow (CBF) in five children with primary autism diagnosed according to the DSM-III-R criteria was studied longitudinally. Regional CBF in each of the autistic children was measured with single photon emission computed tomography twice during their development: at the age of 3-4 years and 3 years later. At each stage, the autistic children were compared to an age-matched comparison group of five nonautistic children with normal development. RESULTS A transient frontal hypoperfusion was found in the autistic children at ages 3-4 years; this corresponded to the pattern of perfusion observed in much younger normal children. By the ages of 6-7, the autistic children's frontal perfusion had attained normal values. CONCLUSIONS Since CBF patterns in children are related to maturational changes in brain function, these results indicate a delayed frontal maturation in childhood autism. Such a delayed brain maturational process is consistent with the clinical data and cognitive performance of autistic children.

[1]  B Horwitz,et al.  The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. , 1988, Archives of neurology.

[2]  A. Volder,et al.  Brain glucose metabolism in children with the autistic syndrome: Positron tomography analysis , 1987, Brain and Development.

[3]  H. Uylings,et al.  Neuronal development in human prefrontal cortex in prenatal and postnatal stages. , 1990, Progress in brain research.

[4]  M. Phelps,et al.  Metabolic Maturation of the Brain: A Study of Local Cerebral Glucose Utilization in the Developing Cat , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  M. Mintun,et al.  A Noninvasive Approach to Quantitative Functional Brain Mapping with H215O and Positron Emission Tomography , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  Nancy J. Minshew,et al.  A preliminary 31P MRS study of autism: Evidence for undersynthesis and increased degradation of brain membranes , 1993, Biological Psychiatry.

[7]  R S Frackowiak,et al.  Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults , 1988, Psychological Medicine.

[8]  M. Phelps,et al.  Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. , 1986, Science.

[9]  E. Ornitz.  The functional neuroanatomy of infantile autism. , 1983, The International journal of neuroscience.

[10]  C. Barthélémy,et al.  Etude des troubles de la communication et de la cognition d'enfants autistiques: analyse «microscopique» de brèves séquences comportementales au cours de la passation de tests psychologiques , 1988 .

[11]  P. Goldman-Rakic.  Development of cortical circuitry and cognitive function. , 1987, Child Development.

[12]  A. Diamond.  Developmental Time Course in Human Infants and Infant Monkeys, and the Neural Bases of, Inhibitory Control in Reaching a , 1990, Annals of the New York Academy of Sciences.

[13]  P. Huttenlocher.  Synaptic density in human frontal cortex - developmental changes and effects of aging. , 1979, Brain research.

[14]  M. Zilbovicius,et al.  Changes in regional cerebral blood flow during brain maturation in children and adolescents. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  J. Mazziotta,et al.  Positron emission tomography study of human brain functional development , 1987, Annals of neurology.

[16]  A R Damasio,et al.  A neurological model for childhood autism. , 1978, Archives of neurology.

[17]  C. Kennedy,et al.  Local cerebral glucose utilization in the newborn macaque monkey , 1982, Annals of neurology.

[18]  J Townsend,et al.  The brain in infantile autism , 1994, Neurology.

[19]  L. Kanner.  Autistic disturbances of affective contact. , 1968, Acta paedopsychiatrica.

[20]  R A Margolin,et al.  Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. , 1985, Archives of general psychiatry.

[21]  E Courchesne,et al.  Effects of focused selective attention tasks on event-related potentials in autistic and normal individuals. , 1990, Electroencephalography and clinical neurophysiology.

[22]  B Mazoyer,et al.  Regional cerebral blood flow in childhood autism: a SPECT study. , 1992, The American journal of psychiatry.

[23]  T. Kemper,et al.  Histoanatomic observations of the brain in early infantile autism , 1985, Neurology.

[24]  G Pearlson,et al.  Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. , 1990, The American journal of psychiatry.

[25]  J. Morton,et al.  The cognitive basis of a biological disorder: autism , 1991, Trends in Neurosciences.

[26]  A. Scheibel,et al.  Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC Autopsy Research Report. , 1986, The American journal of psychiatry.

[27]  J. Rumsey,et al.  Neuropsychological findings in high-functioning men with infantile autism, residual state. , 1988, Journal of clinical and experimental neuropsychology.