Diagnosis of Subcutaneous Metastatic Deposits by Fine Needle Aspiration

Objectives: Subcutaneous tissue is an uncommon site of metastasis. Overall it can be seen in 0.8-4% of the malignancies. Fine Needle Aspiration Cytology (FNAC) is a method for the diagnosis of subcutaneous metastasis and to exclude other differential diagnoses such as primary cutaneous tumors or inflammatory process. In this study we want to report our experience with Fine Needle Aspiration (FNA) of subcutaneous metastasis in 25 patients with known malignancy. Study design: During 3 years, among more than 10000 cytology cases, we had 25 patients with different types of malignancy who were referred with subcutaneous nodules. FNA was performed. Results: In these 25 patients, there were 15 males and 10 female patients (22-80 years of age). Most common malignancy was breast cancer and the most common site of metastasis was subcutaneous tissue of chest wall. FNAC was 100% accurate for the diagnosis of subcutaneous metastasis. There were no false positive and false negative cases. Discussion and conclusion: FNAC is an accurate, noninvasive and fast method for the diagnosis of subcutaneous metastasis in the patients with a known malignancy without any complication.

[1]  Wei-Lien Wang,et al.  Sarcoma metastases to the skin , 2012, Cancer.

[2]  R. Bansal,et al.  Cutaneous and subcutaneous metastases from internal malignancies: An analysis of cases diagnosed by fine needle aspiration , 2011, Diagnostic cytopathology.

[3]  S. Balukrishna,et al.  Solitary Subcutaneous Metastasis from Squamous Cell Carcinoma of the Esophagus: A Case Report and Brief Review of Literature , 2011, Journal of gastrointestinal cancer.

[4]  M. Cho,et al.  Vulvar Skin Metastasis of Lung Squamous Cell Carcinoma , 2011, Annals of dermatology.

[5]  R. Srinivasan,et al.  SQUAMOUS CELL CARCINOMA OF SUPRAGLOTTIC LARYNX WITH METASTASIS TO ALL FIVE DISTAL PHALANGES OF LEFT HAND , 2011, Indian Journal of Dermatology.

[6]  R. Gaba,et al.  Subcutaneous Plasmacytoma Metastasis Precipitated by Tunneled Central Venous Catheter Insertion , 2011, Case Reports in Oncology.

[7]  B. Calvo,et al.  Subcutaneous Metastatic Adenocarcinoma: An Unusual Presentation of Colon Cancer – Case Report and Literature Review , 2010, Case Reports in Oncology.

[8]  B. Geramizadeh,et al.  Subcutaneous metastasis from colon adenocarcinoma diagnosed by fine needle aspiration cytology. , 2010, Acta Cytologica.

[9]  M. Kotru,et al.  Role of fine‐needle aspiration cytology in evaluation of cutaneous metastases , 2009, Diagnostic cytopathology.

[10]  M. Bullock,et al.  Metastatic renal cell carcinoma to the head and neck: summary of 21 cases. , 2008, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale.

[11]  S. Alıcı,et al.  Multiple subcutaneous nodular métastases from transitional cell carcinoma of the bladder , 2008, Pathology and Oncology Research.

[12]  B. Geramizadeh,et al.  Fine needle aspiration of a subcutaneous mass caused by metastatic transitional cell carcinoma. , 2007, Acta cytologica.

[13]  A. Tadayyon,et al.  Subcutaneous Metastasis from Transitional Cell Carcinoma of the Bladder Diagnosed by Fine Needle Aspiration Biopsy , 2000, Acta Cytologica.

[14]  Raj K. Gupta,et al.  Fine Needle Aspiration Cytology of Cutaneous and Subcutaneous Metastatic Deposits from Epithelial Malignancies , 1999, Acta Cytologica.

[15]  V. Reddy,et al.  Malignant cutaneous and subcutaneous abdominal wall lesions: A fine‐needle aspiration study , 1998, Diagnostic Cytopathology.

[16]  B. Eyden,et al.  Clinicopathological characteristics of peripheral primitive neuroectodermal tumour of skin and subcutaneous tissue , 1997, Histopathology.

[17]  T. Tadros,et al.  Sarcomatoid carcinoma of the larynx with neck and distant subcutaneous metastases. A case report with fine needle aspiration cytology. , 1996, Acta Cytologica.

[18]  M. Rock,et al.  Subcutaneous Involvement After a Metacarpal Chondrosarcoma: Case Report and Review of Literature Timothy , 1995, Clinical orthopaedics and related research.

[19]  N. Horiuchi,et al.  Skin metastasis in laryngeal carcinoma , 1992, Clinical and experimental dermatology.