Maternal asthma and pregnancy outcomes: a retrospective cohort study.

OBJECTIVE We examined the relationship between asthma during pregnancy and selected infant and maternal outcomes. STUDY DESIGN A retrospective cohort study was conducted on mother-infant dyads identified from a linked infant and maternal hospital discharge database in the Canadian province of Quebec between fiscal years 1991-1992 and 1995-1996. Mothers with asthma (n = 2193) were compared with a randomly selected control sample (n = 8772) from the remaining population of mothers. RESULTS After important confounding variables were accounted for, maternal asthma was significantly associated with several adverse infant outcomes, including preterm birth and birth of infants who are very small for gestational age, and adverse maternal outcomes, such as idiopathic preterm labor, early idiopathic preterm labor, preeclampsia, transient hypertension of pregnancy, pregnancy-associated hypertension, chorioamnionitis, and cesarean delivery. CONCLUSION Our results demonstrated that pregnant women with asthma are at substantially increased risk for several adverse infant and maternal outcomes and suggest the need for extra attention to mothers with asthma and their infants.

[1]  S. Wen,et al.  Adverse outcomes in pregnancies of asthmatic women: results from a Canadian population. , 2001, Annals of epidemiology.

[2]  M. Schatz.  Asthma and pregnancy , 1999, The Lancet.

[3]  M. Schatz.  Interrelationships between asthma and pregnancy: a literature review. , 1999, The Journal of allergy and clinical immunology.

[4]  K. Demissie,et al.  Infant and maternal outcomes in the pregnancies of asthmatic women. , 1998, American journal of respiratory and critical care medicine.

[5]  L. Dodds,et al.  Perinatal outcomes in women with asthma during pregnancy , 1998, Obstetrics and gynecology.

[6]  S. Marcella,et al.  Maternal Asthma and Transient Tachypnea of the Newborn , 1998, Pediatrics.

[7]  M. Glezerman,et al.  Influence of Asthma in Pregnancy on Labor and the Newborn , 1998, Respiration.

[8]  A. Coates,et al.  Maternal asthma and idiopathic preterm labor. , 1995, American journal of epidemiology.

[9]  M. Kramer,et al.  Comparison of birth weight distributions between Chinese and Caucasian infants. , 1995, American journal of epidemiology.

[10]  S. Saha,et al.  Effect of bronchial asthma on the course of pregnancy, labour and perinatal outcome. , 1995, Journal of obstetrics and gynaecology.

[11]  A. Forsythe,et al.  Perinatal outcomes in the pregnancies of asthmatic women: a prospective controlled analysis. , 1995, American journal of respiratory and critical care medicine.

[12]  S. Riikonen,et al.  Slow-release theophylline in pregnant asthmatics. , 1995, Chest.

[13]  T. Chard,et al.  Use of anthropometric indicators and maternal risk factors to evaluate intrauterine growth retardation in infants weighing more than 2500 grams at birth. , 1994, Early human development.

[14]  R. Berkowitz,et al.  Association between pregnancy-induced hypertension and asthma during pregnancy. , 1993, American journal of obstetrics and gynecology.

[15]  M. Bracken,et al.  Possible Role of Asthma in the Risk of Preterm Labor and Delivery , 1993, Epidemiology.

[16]  M. Morgan,et al.  Severity of asthma and perinatal outcome. , 1992 .

[17]  B. Sibai,et al.  Clinical Observations on Asthma in Pregnancy , 1992 .

[18]  A. Forsythe,et al.  Increased transient tachypnea of the newborn in infants of asthmatic mothers. , 1991, American journal of diseases of children.

[19]  T. Lao,et al.  Labour and delivery in mothers with asthma. , 1990, European journal of obstetrics, gynecology, and reproductive biology.

[20]  M. Kramer,et al.  Body proportionality and head and length 'sparing' in growth-retarded neonates: a critical reappraisal. , 1989, Pediatrics.

[21]  P. Piirilä,et al.  Asthma and pregnancy: a prospective study of 198 pregnancies. , 1988, Thorax.

[22]  M. Dombrowski,et al.  Incidence of preeclampsia among asthmatic patients lower with theophylline. , 1986, American journal of obstetrics and gynecology.

[23]  S. Spector,et al.  Asthma and pregnancy. , 1979, JAMA.

[24]  T. Bjerkedal,et al.  THE COURSE AND OUTCOME OF PREGNANCY IN WOMEN WITH BRONCHIAL ASTHMA , 1972, Acta allergologica.

[25]  A. G. Kantor,et al.  Fetal morbidity following potentially anoxigenic obstetric conditions. VII. Bronchial asthma. , 1970, American journal of obstetrics and gynecology.

[26]  F. McLean,et al.  Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation. , 1969, The Journal of pediatrics.

[27]  A. G. Kantor,et al.  Fetal morbidity following potentially anoxigenic obstetric conditions. VI. Rupture of the marginal sinus. , 1966, American journal of obstetrics and gynecology.

[28]  F. Silverman,et al.  Pregnancy complicated by asthma. , 1961, American journal of obstetrics and gynecology.