In vivo analysis of dermal and systemic absorption of silver nanoparticles through healthy human skin

Research into nanoparticles has increased markedly during the last decade, especially in light of their potential diagnostic and therapeutic use. While silver has been used since ancient times, a detailed understanding of the kinetics of its dermal absorption requires further study. Thus far, only in vitro and animal models have been used to analyse the absorption characteristics of nanocrystalline silver particles and no in vivo study using intact human skin has demonstrated silver absorption.

[1]  K. Andersen,et al.  Clinical performance of a new silver dressing, Contreet Foam, for chronic exuding venous leg ulcers. , 2003, Journal of wound care.

[2]  Claus-Michael Lehr,et al.  Nanoparticles--an efficient carrier for drug delivery into the hair follicles. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  R. Conyers,et al.  Do burn patients have a silver lining? , 1992, Burns : journal of the International Society for Burn Injuries.

[4]  R. Burrell.  A scientific perspective on the use of topical silver preparations. , 2003, Ostomy/Wound Management.

[5]  Hiroyuki Ohshima,et al.  In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size. , 2008, Colloids and surfaces. B, Biointerfaces.

[6]  G. Danscher.  Autometallography , 2004, Histochemistry.

[7]  M. Pollini,et al.  Engineering Nanostructured Silver Coatings for Antimicrobial Applications , 2012 .

[8]  Vo Van Toi,et al.  The Third International Conference on the Development of Biomedical Engineering in Vietnam , 2010 .

[9]  V Wendel,et al.  Distribution of sunscreens on skin. , 2002, Advanced drug delivery reviews.

[10]  S. Djokić.  Treatment of Various Surfaces with Silver and its Compounds for Topical Wound Dressings, Catheter and Other Biomedical Applications , 2008, ECS Transactions.

[11]  N. Monteiro-Riviere,et al.  Penetration of intact skin by quantum dots with diverse physicochemical properties. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[12]  B. van Ravenzwaay,et al.  The significance of in vitro rat skin absorption studies to human risk assessment. , 2004, Toxicology in vitro : an international journal published in association with BIBRA.

[13]  M. López-Quintela,et al.  Penetration of metallic nanoparticles in human full-thickness skin. , 2007, The Journal of investigative dermatology.

[14]  U. Epa.  Dermal exposure assessment: Principles and applications , 1992 .

[15]  M. Roberts,et al.  Human Skin Penetration of Sunscreen Nanoparticles: In-vitro Assessment of a Novel Micronized Zinc Oxide Formulation , 2007, Skin Pharmacology and Physiology.

[16]  Marc Schneider,et al.  Nanoparticles and their interactions with the dermal barrier , 2009, Dermato-endocrinology.

[17]  F. Bérard,et al.  Allergen penetration through the skin. , 2003, European journal of dermatology : EJD.

[18]  H. Junginger,et al.  Interactions of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy. , 1999, Biochimica et biophysica acta.

[19]  J. Bouwstra,et al.  Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. , 2004, The Journal of investigative dermatology.

[20]  Jenny R. Roberts,et al.  Skin as a route of exposure and sensitization in chronic beryllium disease. , 2003, Environmental health perspectives.

[21]  Herman J. C. Berendsen,et al.  Permeation Process of Small Molecules across Lipid Membranes Studied by Molecular Dynamics Simulations , 1996 .

[22]  R. Wepf,et al.  The Human Stratum corneum Layer: An Effective Barrier against Dermal Uptake of Different Forms of Topically Applied Micronised Titanium Dioxide , 2001, Skin Pharmacology and Physiology.

[23]  S. Mitragotri,et al.  Current status and future potential of transdermal drug delivery , 2004, Nature Reviews Drug Discovery.

[24]  Ulrike Blume-Peytavi,et al.  40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. , 2006, The Journal of investigative dermatology.

[25]  A. Lansdown,et al.  A Pharmacological and Toxicological Profile of Silver as an Antimicrobial Agent in Medical Devices , 2010, Advances in pharmacological sciences.

[26]  Massimo Bovenzi,et al.  Human skin penetration of cobalt nanoparticles through intact and damaged skin. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[27]  Massimo Bovenzi,et al.  Human skin penetration of silver nanoparticles through intact and damaged skin. , 2009, Toxicology.