Gabor fusion master slave optical coherence tomography.

This paper describes the application of the Gabor filtering protocol to a Master/Slave (MS) swept source optical coherence tomography (SS)-OCT system at 1300 nm. The MS-OCT system delivers information from selected depths, a property that allows operation similar to that of a time domain OCT system, where dynamic focusing is possible. The Gabor filtering processing following collection of multiple data from different focus positions is different from that utilized by a conventional swept source OCT system using a Fast Fourier transform (FFT) to produce an A-scan. Instead of selecting the bright parts of A-scans for each focus position, to be placed in a final B-scan image (or in a final volume), and discarding the rest, the MS principle can be employed to advantageously deliver signal from the depths within each focus range only. The MS procedure is illustrated on creating volumes of data of constant transversal resolution from a cucumber and from an insect by repeating data acquisition for 4 different focus positions. In addition, advantage is taken from the tolerance to dispersion of the MS principle that allows automatic compensation for dispersion created by layers above the object of interest. By combining the two techniques, Gabor filtering and Master/Slave, a powerful imaging instrument is demonstrated. The master/slave technique allows simultaneous display of three categories of images in one frame: multiple depth en-face OCT images, two cross-sectional OCT images and a confocal like image obtained by averaging the en-face ones. We also demonstrate the superiority of MS-OCT over its FFT based counterpart when used with a Gabor filtering OCT instrument in terms of the speed of assembling the fused volume. For our case, we show that when more than 4 focus positions are required to produce the final volume, MS is faster than the conventional FFT based procedure.

[1]  Adrian Bradu,et al.  Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography. , 2014, Biomedical optics express.

[2]  Adrian Gh. Podoleanu,et al.  Combinations of techniques in imaging the retina with high resolution , 2008, Progress in Retinal and Eye Research.

[3]  David D Sampson,et al.  Energy-efficient low-Fresnel-number Bessel beams and their application in optical coherence tomography. , 2014, Optics letters.

[4]  Liang Liu,et al.  Imaging the anterior eye with dynamic-focus swept-source optical coherence tomography , 2015, Journal of biomedical optics.

[5]  A. Bradu,et al.  Demonstration of tolerance to dispersion of master/slave interferometry. , 2015, Optics express.

[6]  R. Leitgeb,et al.  Extended focus depth for Fourier domain optical coherence microscopy. , 2006, Optics letters.

[7]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[8]  Adrian Bradu,et al.  Master slave en-face OCT/SLO. , 2015, Biomedical optics express.

[9]  Zhihua Ding,et al.  High-resolution optical coherence tomography over a large depth range with an axicon lens. , 2002, Optics letters.

[10]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[11]  Adrian Bradu,et al.  On the possibility of producing true real-time retinal cross-sectional images using a graphics processing unit enhanced master-slave optical coherence tomography system , 2015, Journal of biomedical optics.

[12]  Martin F. Kraus,et al.  Swept source optical coherence microscopy using a 1310 nm VCSEL light source. , 2013, Optics express.

[13]  Panomsak Meemon,et al.  Gabor-based fusion technique for Optical Coherence Microscopy. , 2010, Optics express.

[14]  David D. Sampson,et al.  Quantifying the influence of Bessel beams on image quality in optical coherence tomography , 2016, Scientific Reports.

[15]  V. Srinivasan,et al.  Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast , 2012, Optics express.

[16]  PANOMSAK MEEMON,et al.  Spectral fusing Gabor domain optical coherence microscopy. , 2016, Optics letters.

[17]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[18]  Adrian Bradu,et al.  Swept source optical coherence tomography Gabor fusion splicing technique for microscopy of thick samples using a deformable mirror , 2015, Journal of biomedical optics.

[19]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[20]  Michael Hughes,et al.  Simplified dynamic focus method for time domain OCT , 2009 .

[21]  Adrian Bradu,et al.  Master-slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography. , 2013, Optics express.

[22]  W. Drexler,et al.  Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length. , 2014, Optics express.

[23]  Adrian Bradu,et al.  Master/slave interferometry - ideal tool for coherence revival swept source optical coherence tomography. , 2016, Biomedical optics express.

[24]  Adrian Bradu,et al.  Complex master slave interferometry. , 2016, Optics express.

[25]  J. Fujimoto,et al.  Optical coherence tomography using a frequency-tunable optical source. , 1997, Optics letters.