Plasma fractionation in the United States. A review for clinicians.

The Cohn cold ethanol plasma fractionation system, developed in the late 1940s, is still the basis for plasma fractionation practices in the United States today. Plasma is obtained by plasmapheresis, salvaged from fresh or outdated whole blood, or is extracted from human placentas to produce five types of clinical products of proven efficacy and safety. Despite the recognized advantages and current entrenchment of the Cohn fractionation system and its partial solution of the hepatitis problem, new developments could improve the present practice. Improved salvage of useful proteins from fractions that are currently discarded must be strongly supported. (JAMA230:247-250, 1974)

[1]  C. Rath,et al.  Prothrombin complex concentrates in acquired hypoprothrombinemia. , 1973, Annals of internal medicine.

[2]  R. Purcell,et al.  Posttransfusion hepatitis after exclusion of commercial and hepatitis-B antigen-positive donors. , 1972, Annals of internal medicine.

[3]  J. G. Watt.  Automatic Fractionation of Plasma Proteins , 1972 .

[4]  J. Sgouris.  VIII. The Current Status of Blood Fractionation in the United States , 1972, Vox sanguinis.

[5]  Y. Hao,et al.  Large Scale Preparation of Macroglobulins , 1972, Vox sanguinis.

[6]  D. Deykin,et al.  Hepatitis after Konyne administration. , 1971, The New England journal of medicine.

[7]  F. Camp,et al.  The occurrence of blood group substances A and B in proprietary gamma globulin of placental origin. Rep No 807. , 1968, Report. Army Medical Research Laboratory.

[8]  C. Merskey,et al.  The Defibrination Syndrome: Clinical Features and Laboratory Diagnosis , 1967, British journal of haematology.

[9]  V. Marder,et al.  Major surgery in classic hemophilia using fraction I: Experience in twelve operations and review of the literature , 1966 .

[10]  P. J. Schwab,et al.  Plasmapheresis with simple equipment. , 1961, Technical bulletin of the Registry of Medical Technologists. American Society of Clinical Pathologists. Registry of Medical Technologists.

[11]  J. Hidalgo,et al.  Preparation and Properties of a Heat‐Treated Human Plasma Protein Fraction , 1957, Vox sanguinis.

[12]  R. Murray,et al.  Safety of Immune Serum Globulin with Respect to Homologous Serum Hepatitis.∗ , 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[13]  J. Oncley,et al.  The separation of the antibodies, isoagglutinins, prothrombin, plasminogen and beta1-lipoprotein into subfractions of human plasma. , 1949, Journal of the American Chemical Society.

[14]  C. Janeway,et al.  CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVI. INACTIVATION OF THE VIRUS OF HOMOLOGOUS SERUM HEPATITIS IN SOLUTIONS OF NORMAL HUMAN SERUM ALBUMIN BY MEANS OF HEAT. , 1948, The Journal of clinical investigation.

[15]  Strong Le,et al.  Preparation and properties of serum and plasma proteins; a system for the separation into fractions of the protein and lipoprotein components of biological tissues and fluids. , 1946 .