Evaluation of Effect of Topical Application of Ps-35 on Patients Affected with Chronic Plaque Psoriasis: A Clinical Study

Background: Psoriasis is a chronic, immune-mediated, inflammatory systemic skin disorder that predominantly involves the skin, nails, and joints. It affects approximately 2% of the population and poses a lifelong burden on those, affected. Objective: To evaluate the efficacy of topical application of Novel Botanical Formulation PS-35 on psoriasis affected areas of the body and to evaluate whether PS-35 can be recommended as safe and effective topical dosage form for treatment of plaque psoriasis. Methods: Totally 185 patients were selected for the study on the basis of PASI score (<10%). Patients were given the topical application of PS-35 twice a day. The duration of therapy was at least 12 weeks and effect of withdrawal of therapy was observed for 15 weeks. Results: The results showed the reduction in itchiness (90%), scaliness (91.5%), hard plaque (88%) and hyperpigmentation (78%). No relapse of psoriatic symptoms was observed in 56.6% patients. Conclusion: The topical application of PS-35 is found to be an acceptable and effective method to treat symptoms of chronic plaque psoriasis.