Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
暂无分享,去创建一个
S. Teichmann | N. Sebire | A. Hayday | C. E. Villa | G. Testa | S. Boeing | D. Bonnet | Jong-Eun Park | H. Stauss | P. Bonfanti | M. Muñoz-Ruiz | L. Ariza-McNaughton | Constance Maurer | J. C. Hutchinson | A. Gjinovci | S. Campinoti | P. G. Manti | M. Catucci | Luca Zanieri | R. Ragazzini | D. Phylactopoulos | Gianluca Vozza | Roberta Ragazzini | L. Ariza‐McNaughton
[1] J. Kurtzberg,et al. Histopathologic assessment of cultured human thymus , 2020, PloS one.
[2] S. Teichmann,et al. A cell atlas of human thymic development defines T cell repertoire formation , 2020, Science.
[3] Paul J. Hoffman,et al. Comprehensive Integration of Single-Cell Data , 2018, Cell.
[4] Eyal David,et al. Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells , 2018, Nature.
[5] Allon M. Klein,et al. A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte , 2018, Nature.
[6] Ping Xu,et al. A Single‐Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation , 2018, Immunity.
[7] Tomislav Ilicic,et al. Single-cell RNA-sequencing resolves self-antigen expression during mTEC development , 2018, Scientific Reports.
[8] Skin regeneration with insights , 2017, Nature.
[9] T. Boehm,et al. Genetic and non-genetic determinants of thymic epithelial cell number and function , 2017, Scientific Reports.
[10] Graham Anderson,et al. Thymic Epithelial Cells. , 2017, Annual review of immunology.
[11] Kathryn L. Parsley,et al. Thymus transplantation for complete DiGeorge syndrome: European experience , 2017, Journal of Allergy and Clinical Immunology.
[12] David Baltimore,et al. Generation of mature T cells from human hematopoietic stem/progenitor cells in artificial thymic organoids , 2017, Nature Methods.
[13] J. Gribben,et al. Versatile humanized niche model enables study of normal and malignant human hematopoiesis , 2017, The Journal of clinical investigation.
[14] J. Werkmeister,et al. Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation. , 2017, Biomaterials.
[15] C. Ponting,et al. Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells , 2016, Nature Immunology.
[16] N. Minato,et al. Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution , 2016, Immunological reviews.
[17] H. Rodewald,et al. Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus , 2015, The Journal of Immunology.
[18] David Zemmour,et al. Aire controls gene expression in the thymic epithelium with ordered stochasticity , 2015, Nature Immunology.
[19] Wolfgang Huber,et al. Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells , 2015, Nature Immunology.
[20] M. Trucco,et al. Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.
[21] O. Yang,et al. Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo , 2014, Stem cells.
[22] B. Kyewski,et al. Adult Thymus Contains FoxN1− Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages , 2014, Immunity.
[23] D. Gray,et al. Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus. , 2014, Cell Reports.
[24] H. Ott,et al. Decellularized scaffolds as a platform for bioengineered organs , 2014, Current opinion in organ transplantation.
[25] D. Wiest,et al. The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification , 2014, The Journal of experimental medicine.
[26] Yongwon Choi,et al. Identification of Novel Thymic Epithelial Cell Subsets Whose Differentiation Is Regulated by RANKL and Traf6 , 2014, PloS one.
[27] Qi-hua He,et al. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. , 2013, Cell stem cell.
[28] Mark S. Anderson,et al. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. , 2013, Cell stem cell.
[29] T. Boehm,et al. Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments , 2012, Cell.
[30] B. Ryffel,et al. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. , 2012, Immunity.
[31] C. Betsholtz,et al. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. , 2011, Developmental cell.
[32] F. Miedema,et al. Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration? , 2011, Blood.
[33] S. Rafii,et al. Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells , 2010, Nature Cell Biology.
[34] Y. Barrandon,et al. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells , 2010, Nature.
[35] J. D. Di Santo,et al. Cutting Edge: A Thymocyte-Thymic Epithelial Cell Cross-Talk Dynamically Regulates Intrathymic IL-7 Expression In Vivo , 2010, The Journal of Immunology.
[36] W. Vermi,et al. Thymus microenvironment in human primary immunodeficiency diseases , 2009, Current opinion in allergy and clinical immunology.
[37] L. Notarangelo,et al. Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome. , 2009, Blood.
[38] U. Lorenz,et al. SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels , 2009, Immunological reviews.
[39] S. Parnell,et al. Checkpoints in the Development of Thymic Cortical Epithelial Cells1 , 2009, The Journal of Immunology.
[40] Y. Yanagawa,et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance , 2008, The Journal of experimental medicine.
[41] N. Manley,et al. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment , 2008, The Journal of experimental medicine.
[42] José A. M. Borghans,et al. Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool , 2008, Proceedings of the National Academy of Sciences.
[43] T. Boehm. Thymus development and function. , 2008, Current opinion in immunology.
[44] M. Sampaolesi,et al. Isolation and characterization of mesoangioblasts from mouse, dog, and human tissues. , 2007, Current protocols in stem cell biology.
[45] F. McKeon,et al. p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia , 2007, Cell.
[46] A. Aguzzi,et al. Expression of lymphotoxin beta governs immunity at two distinct levels , 2006, European journal of immunology.
[47] G. Anderson,et al. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium , 2006, Nature.
[48] Kenneth G. Johnson,et al. CD22 Is a Functional Ligand for SH2 Domain-containing Protein-tyrosine Phosphatase-1 in Primary T Cells* , 2004, Journal of Biological Chemistry.
[49] A. Andreotti,et al. Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. , 2004, Immunity.
[50] G. Anderson,et al. Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors , 2003, The Journal of experimental medicine.
[51] F. Watt,et al. Role of integrins in regulating epidermal adhesion, growth and differentiation , 2002, The EMBO journal.
[52] K. Höffken,et al. The European experience. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[53] E. Jenkinson,et al. An Essential Role for Thymic Mesenchyme in Early T Cell Development , 2000, The Journal of experimental medicine.
[54] F. Watt,et al. Expression and function of the keratinocyte integrins. , 1993, Development (Cambridge, England). Supplement.
[55] T. Nakayama,et al. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. , 1993, International immunology.
[56] G. Koretzky,et al. CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line. , 1993, The Journal of biological chemistry.
[57] G. Anderson,et al. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus , 1993, Nature.
[58] G. Janossy,et al. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. , 1988, Journal of immunology.
[59] Y. Barrandon,et al. Three clonal types of keratinocyte with different capacities for multiplication. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[60] H. Rodewald. Thymus organogenesis. , 2008, Annual review of immunology.