Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

Overview Homeostasis in the cardiovascular system is maintained by a hierarchy of interacting genetic and epigenetic programs, the disequilibrium of which contributes to the pathogenesis of complex disease processes such as atherosclerosis and its lifethreatening complications, myocardial infarction, and stroke. Vascular endothelium, the continuous cellular lining of the cardiovascular system, Nature’s container for blood, is an important locus of critical regulatory nodes in this homeostatic network. In health, this distributed organ supports the normal functioning of the various tissues and organs of the body; in disease, its dysfunction within the walls of large arteries is an Atherosclerosis Compendium

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