Hippocampal and Frontolimbic Function as Intermediate Phenotype for Psychosis: Evidence from Healthy Relatives and a Common Risk Variant in CACNA1C

[1]  P. Janicak,et al.  Calcium channel antagonists for the treatment of bipolar disorder. , 2000, Bipolar disorders.

[2]  P. Sullivan,et al.  Genetic epidemiology of major depression: review and meta-analysis. , 2000, The American journal of psychiatry.

[3]  Bruce S. McEwen,et al.  Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders , 2001, Human psychopharmacology.

[4]  P. Sullivan,et al.  Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. , 2003, Archives of general psychiatry.

[5]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[6]  P. Sham,et al.  The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. , 2003, Archives of general psychiatry.

[7]  Franz Hofmann,et al.  Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory , 2005, The Journal of Neuroscience.

[8]  F. Holsboer,et al.  Stress and the brain: from adaptation to disease , 2005, Nature Reviews Neuroscience.

[9]  A. Meyer-Lindenberg,et al.  Intermediate phenotypes and genetic mechanisms of psychiatric disorders , 2006, Nature Reviews Neuroscience.

[10]  W. Drevets,et al.  Toward Constructing an Endophenotype Strategy for Bipolar Disorders , 2006, Biological Psychiatry.

[11]  Jason J. Corneveaux,et al.  Common Kibra Alleles Are Associated with Human Memory Performance , 2006, Science.

[12]  R. Kahn,et al.  Genetic influences on human brain structure: A review of brain imaging studies in twins , 2007, Human brain mapping.

[13]  Yongjun Qin,et al.  Glucocorticoids specifically enhance L-type calcium current amplitude and affect calcium channel subunit expression in the mouse hippocampus. , 2007, Journal of neurophysiology.

[14]  Douglas B. Ehlenberger,et al.  Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex , 2008, The Journal of comparative neurology.

[15]  M. Joëls,et al.  Stress-induced changes in hippocampal function. , 2008, Progress in brain research.

[16]  S. Gabriel,et al.  Whole-genome association study of bipolar disorder , 2008, Molecular Psychiatry.

[17]  Eric J. Nestler,et al.  The molecular neurobiology of depression , 2008, Nature.

[18]  Manuel A. R. Ferreira,et al.  Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder , 2008, Nature Genetics.

[19]  M. Phillips,et al.  A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder , 2008, Molecular Psychiatry.

[20]  Peter Kirsch,et al.  Brain function in carriers of a genome-wide supported bipolar disorder variant. , 2010, Archives of general psychiatry.

[21]  T. Werge,et al.  CACNA1C (rs1006737) is associated with schizophrenia , 2010, Molecular Psychiatry.

[22]  M C O'Donovan,et al.  The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia , 2009, Molecular Psychiatry.

[23]  Stephan Heckers,et al.  Hippocampal pathology in schizophrenia. , 2010, Current topics in behavioral neurosciences.

[24]  T. Suppes,et al.  Genetics and intermediate phenotypes of the schizophrenia—bipolar disorder boundary , 2010, Neuroscience & Biobehavioral Reviews.

[25]  Joseph H Callicott,et al.  Genetic variation in CACNA1C affects brain circuitries related to mental illness. , 2010, Archives of general psychiatry.

[26]  A. Wagner,et al.  The hippocampal formation in schizophrenia. , 2010, The American journal of psychiatry.

[27]  Richard J. Davidson,et al.  Amygdalar and hippocampal substrates of anxious temperament differ in their heritability , 2010, Nature.

[28]  D. Grozeva,et al.  Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. , 2011, Human molecular genetics.

[29]  B. Rasch,et al.  Statistical Epistasis and Functional Brain Imaging Support a Role of Voltage-Gated Potassium Channels in Human Memory , 2011, PloS one.

[30]  A. Grace,et al.  Developmental pathology, dopamine, stress and schizophrenia , 2011, International Journal of Developmental Neuroscience.

[31]  G. MacQueen,et al.  The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? , 2011, Molecular Psychiatry.

[32]  I. L. Nieuwenhuis,et al.  The role of the ventromedial prefrontal cortex in memory consolidation , 2011, Behavioural Brain Research.

[33]  D. Clair,et al.  Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder , 2011, Molecular Psychiatry.

[34]  Andreas Papassotiropoulos,et al.  Genetics of human episodic memory: dealing with complexity , 2011, Trends in Cognitive Sciences.

[35]  Thomas W. Mühleisen,et al.  Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Variant , 2011, The Journal of Neuroscience.

[36]  Panos Roussos,et al.  The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males , 2011, Bipolar disorders.

[37]  G. Rebec,et al.  Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction , 2011, Neuroscience.

[38]  E. Vassos,et al.  The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder , 2011, Molecular Psychiatry.

[39]  Andreas Meyer-Lindenberg,et al.  Neural mechanisms of social risk for psychiatric disorders , 2012, Nature Neuroscience.

[40]  Marian Joëls,et al.  Corticosteroid effects on calcium signaling in limbic neurons. , 2012, Cell calcium.

[41]  N. Nicolson,et al.  Hippocampal volume as marker of daily life stress sensitivity in psychosis , 2012, Psychological Medicine.

[42]  Shambhu Bhat,et al.  CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease , 2012, Progress in Neurobiology.

[43]  A. Meyer-Lindenberg,et al.  Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication , 2012, Neuroscience & Biobehavioral Reviews.

[44]  F. Hofmann,et al.  Forebrain elimination of cacna1c mediates anxiety-like behavior in mice , 2012, Molecular Psychiatry.

[45]  D. Linden.  The Challenges and Promise of Neuroimaging in Psychiatry , 2012, Neuron.

[46]  Christian Thoresen,et al.  CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls , 2013, PloS one.

[47]  S. Cichon,et al.  Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support , 2013, Translational Psychiatry.

[48]  S Purcell,et al.  Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC , 2013, Molecular Psychiatry.

[49]  M. Daly,et al.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.

[50]  Tilo Kircher,et al.  A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval , 2014, European Archives of Psychiatry and Clinical Neuroscience.

[51]  M C O'Donovan,et al.  Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case–control sample , 2013, Molecular Psychiatry.