Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
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P. Kwok | A. Balmain | L. Pawlikowska | J. Khan | Jun S. Wei | Yoon-Jae Cho | T. van Dyke | J. Mao | W. Weiss | Justin Chen | Q. Fan | D. Quigley | W. C. Gustafson | S. Kozlov | Young K. Song | Christine M. Cheng | David D. Goldenberg | Kim N Nguyen | Yun Bao | Christopher S. Hackett | J. Cook | S. Rallapalli | Robyn A. Wong | J. Cook | C. Cheng | W. Gustafson | Young K Song | Terry Van Dyke
[1] H. Hakonarson,et al. Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma , 2012, Nature Genetics.
[2] P. Branchereau,et al. GABAA Receptor and Glycine Receptor Activation by Paracrine/Autocrine Release of Endogenous Agonists: More Than a Simple Communication Pathway , 2011, Molecular Neurobiology.
[3] Joseph T. Glessner,et al. Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci , 2011, PLoS genetics.
[4] Nazneen Rahman,et al. Integrative genomics identifies LMO1 as a neuroblastoma oncogene , 2011, Nature.
[5] D. Pomp,et al. Dietary fat alters pulmonary metastasis of mammary cancers through cancer autonomous and non-autonomous changes in gene expression , 2010, Clinical & Experimental Metastasis.
[6] J. Rachmilewitz,et al. Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism , 2009, The Journal of Immunology.
[7] Nazneen Rahman,et al. Common variations in BARD1 influence susceptibility to high-risk neuroblastoma , 2009, Nature Genetics.
[8] Xia Yang,et al. Validation of Candidate Causal Genes for Abdominal Obesity Which Affect Shared Metabolic Pathways and Networks , 2009, Nature Genetics.
[9] Hiroki Nagase,et al. Genetic architecture of murine skin inflammation and tumor susceptibility , 2016 .
[10] D. Koomoa,et al. Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma. , 2008, Cancer research.
[11] B. Berwin,et al. Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression. , 2008, Molecular immunology.
[12] W. London,et al. ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma. , 2008, Cancer research.
[13] Gudrun Schleiermacher,et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma , 2008, Nature.
[14] John M. Maris,et al. Identification of ALK as a major familial neuroblastoma predisposition gene , 2008, Nature.
[15] N. Crawford,et al. Bromodomain 4 activation predicts breast cancer survival , 2008, Proceedings of the National Academy of Sciences.
[16] Robert W. Williams,et al. The Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival , 2008, Clinical & Experimental Metastasis.
[17] Joshua L. Deignan,et al. Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia. , 2008, Molecular genetics and metabolism.
[18] A. Manira,et al. Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation , 2008, Nature.
[19] J. Folkman,et al. Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. , 2007, Cancer research.
[20] W. Durante,et al. ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION , 2007, Clinical and experimental pharmacology & physiology.
[21] S. Snyder,et al. Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor , 2007, Proceedings of the National Academy of Sciences.
[22] A. Balmain,et al. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice , 2007, Nature.
[23] Antonio Ortega,et al. Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. , 2006, Journal of the National Cancer Institute.
[24] A. Balmain,et al. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[25] Bruce T Lahn,et al. Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice , 2006, Nature Genetics.
[26] Isabelle Janoueix-Lerosey,et al. Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. , 2005, Cancer letters.
[27] P. Pharoah,et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1 , 2005, Nature Genetics.
[28] M. Mori,et al. GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[29] E. Rappaport,et al. Germline PHOX2B mutation in hereditary neuroblastoma. , 2004, American journal of human genetics.
[30] E. Gerner,et al. Polyamines and cancer: old molecules, new understanding , 2004, Nature Reviews Cancer.
[31] A. Contestabile,et al. Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation , 2004, Journal of Cell Science.
[32] W. Grody,et al. Widespread Expression of Arginase I in Mouse Tissues: Biochemical and Physiological Implications , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[33] Ajay N. Jain,et al. Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors. , 2003, Cancer research.
[34] Hiroki Nagase,et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human , 2003, Nature Genetics.
[35] Hao Wu,et al. R/qtl: QTL Mapping in Experimental Crosses , 2003, Bioinform..
[36] R. Stoughton,et al. Genetics of gene expression surveyed in maize, mouse and man , 2003, Nature.
[37] W. Grody,et al. Arginase expression in mouse embryonic development , 2002, Mechanisms of Development.
[38] Ching Yu Austin Huang,et al. SNPstream UHT: ultra-high throughput SNP genotyping for pharmacogenomics and drug discovery. , 2002, BioTechniques.
[39] L. Kruglyak,et al. Genetic Dissection of Transcriptional Regulation in Budding Yeast , 2002, Science.
[40] Albert-László Barabási,et al. Genetic Dissection of Transcriptional Regulation in Budding Yeast , 2002 .
[41] W. Grody,et al. Expression of arginase isozymes in mouse brain , 2001, Journal of neuroscience research.
[42] T. M. Hsu,et al. Universal SNP genotyping assay with fluorescence polarization detection. , 2001, BioTechniques.
[43] R. Tibshirani,et al. Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[44] S. Cederbaum,et al. Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. , 2000, Cancer research.
[45] Xiaohui He,et al. Pharmacophore/Receptor Models for GABAA/BzR Subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a Comprehensive Ligand-Mapping Approach , 2000 .
[46] R. Mckernan,et al. Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. , 2000, Journal of medicinal chemistry.
[47] R. Mckernan,et al. Pharmacophore/receptor models for GABA(A)/BzR alpha2beta3gamma2, alpha3beta3gamma2 and alpha4beta3gamma2 recombinant subtypes. Included volume analysis and comparison to alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2 subtypes. , 2000, Drug design and discovery.
[48] J. Boucher,et al. Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages. , 1999, Nitric oxide : biology and chemistry.
[49] G. Mohapatra,et al. Targeted expression of MYCN causes neuroblastoma in transgenic mice , 1997, The EMBO journal.
[50] Arthur M Buchberg,et al. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin -induced intestinal neoplasia , 1995, Cell.
[51] P Rhodes,et al. Roles of nitric oxide in tumor growth. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[52] G. Hale,et al. Impact of gender on the natural history of neuroblastoma. , 1994, Pediatric hematology and oncology.
[53] J L Cleveland,et al. The ornithine decarboxylase gene is a transcriptional target of c-Myc. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[54] R. Macdonald,et al. Guanidino compounds that are increased in hyperargininemia inhibit GABA and glycine responses on mouse neurons in cell culture , 1991, Epilepsy Research.
[55] A. Guidotti,et al. Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[56] J. Trent,et al. Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc , 1984, Nature.
[57] H. Varmus,et al. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. , 1984, Science.