Quebec Cooperative Study of Friedreich ' s Ataxia The Beta-Amino Acid Transport System in Friedreich ' s Ataxia

Taurine and B-alanine uptake in cultured skin fibroblasts proceeds through at least two distinct amino acid transport systems. The predominant Bamino acid uptake system which we refer to as the "Beta" system, incorporates taurine in a proportion of 95%, B-alanine in a proportion of 80% and does not incorporate f}-amino-isobutyric acid. A second transport system for B-alanine seems to be operative in cultured skin fibroblasts and

[1]  R. Huxtable,et al.  The mechanism of the adrenergic stimulation of taurine influx in the heart. , 1980, European journal of pharmacology.

[2]  R. Chesney,et al.  The influence of glutathione oxidation on renal cortex taurine transport. , 1979, Life sciences.

[3]  W Shain,et al.  High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells. , 1979, The Journal of biological chemistry.

[4]  R. Chesney,et al.  Developmental Aspects of Renal β-Amino Acid Transport I. Ontogeny of Taurine Reabsorption and Accumulation in Rat Renal Cortex , 1979, Pediatric Research.

[5]  R. Chesney,et al.  Developmental Aspects of Renal β-Amino Acid Transport II. Ontogeny of Uptake and Efflux Processes and Effect of Anoxia , 1979, Pediatric Research.

[6]  P. Mandel,et al.  CHARACTERIZATION OF TAURINE UPTAKE BY NEURONAL AND GLIAL CELLS IN CULTURE , 1979, Journal of neurochemistry.

[7]  A. Filla,et al.  Pilot Studies on Membranes and some Transport Mechanisms in Friedreich's Ataxia , 1979, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[8]  G. Fontaine,et al.  Dicarboxylic Amino Acid Uptake in Normal, Friedreich's Ataxia, and Dicarboxylic Aminoaciduria Fibroblasts , 1979, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[9]  H. Yamamura,et al.  Regional Distribution of Amino Acids in Friedreich's Ataxia Brains , 1979, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[10]  P. Mandel,et al.  Effect of cyclic nucleotides on high affinity uptake ofl-glutamate and taurine in glial and neuroblastoma cells , 1979, Brain Research.

[11]  R. Rozen,et al.  Taurine transport in renal brush-border-membrane vesicles. , 1979, The Biochemical journal.

[12]  G. Guidotti,et al.  The regulation of amino acid transport in animal cells. , 1978, Biochimica et biophysica acta.

[13]  J. Chubb,et al.  Isoproterenol-stimulated taurine influx in the perfused rat heart. , 1978, European journal of pharmacology.

[14]  J. Chubb,et al.  The effects of isoproterenol on taurine concentration in the rat heart. , 1978, European journal of pharmacology.

[15]  R. Butterworth,et al.  Platelet Taurine Uptake in Spinocerebellar Degeneration , 1978, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[16]  J. Chubb,et al.  Adrenergic stimulation of taurine transport by the heart. , 1977, Science.

[17]  G. Geoffroy,et al.  Amino Acid Metabolism in Friedreich's Ataxia , 1976, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[18]  C. Randt,et al.  Amino acid transport inhibition: Brain and behavioral correlates , 1976, Pharmacology Biochemistry and Behavior.

[19]  T. Uozumi,et al.  β-Alaninuria in Patients with Tuberculosis , 1968, Nature.

[20]  D. W. Neill,et al.  Familial Camptodactyly with Taurinuria , 1966, Journal of medical genetics.

[21]  H. Yamamura,et al.  Taurine: sodium-dependent, high-affinity transport into rat brain synaptosomes. , 1978, Molecular pharmacology.

[22]  B. Sacktor,et al.  Transport of beta-alanine in renal brush border membrane vesicles. , 1978, Biochimica et biophysica acta.

[23]  R. Chesney,et al.  Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice. , 1976, The Journal of clinical investigation.

[24]  A. Caralps,et al.  Beta-alaninuria following human renal allotransplantation. , 1968, Clinica chimica acta; international journal of clinical chemistry.