Risk Assessment of nCOVID-19 Pandemic In India: A Mathematical Model And Simulation

The entire world is now eventually locked down due to the outbreak of nCOVID-19 corona virus outbreak. The fast and relentless spread nCOVID-19 has basically segmented the populace only into merely into three classes, such as susceptible, infected and recovered compartments. Adapting the classical SEIR- type epidemic modelling framework, the direct person-to-person contact transmission is taken as the direct route of transmission of nCOVID-19 pandemic. In this research, the authors have developed a model of the nation-wide trends of the outburst of the nCOVID-19 infection using an SEIR Model. The SEIR dynamics are expressed using ordinary differential equations. The creators initially determined the parameters of the model from the accessible day by day information for Indian States dependent on around 35 days history of diseases, recuperation and deaths. The determined parameters have been amassed to extend future patterns for the Indian subcontinent, which is right now at a beginning time in the contamination cycle. The novelty of the study lies in the prediction of both the pessimistic and optimistic mathematical model based comprehensive analysis of nCOVID-19 infection spreading, for two different conditions: (a) if lock down gets withdrawn and (b) if lock down continues as a whole. If the complete lock down in India is withdrawn on 14th April 2020, as a whole, then from the simulation, the authors have predicted that the infected population will flare-up to a large extent , suddenly, however, gradual or zone specific withdrawal would be more effective solution. This study also suggested some possible way-out to get rid of this situation by providing a trade-off between "flattening of the curve" as well as less economic turbulence. The projections are intended to provide a base/ action plan for the socio-economic counter measures to alleviate nCOVID-19.

[1]  J. Hageman The Coronavirus Disease 2019 (COVID-19). , 2020, Pediatric annals.

[2]  Noble K. Kurian Novel Coronavirus (COVID-19) in India , 2020 .

[3]  Christian Drosten,et al.  Identification of a novel coronavirus in patients with severe acute respiratory syndrome. , 2003, The New England journal of medicine.

[4]  Yi Huang,et al.  Measles vaccination in infants younger than 9 months. , 2020, The Lancet. Infectious diseases.

[5]  R. Venkatesha Prasad,et al.  A simple Stochastic SIR model for COVID 19 Infection Dynamics for Karnataka: Learning from Europe , 2020 .

[6]  Novel Coronavirus Pneumonia Emergency Response Epidemiol Team [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. , 2020, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

[7]  Robin N. Thompson,et al.  Pandemic potential of 2019-nCoV , 2020, The Lancet Infectious Diseases.

[8]  L. Meyers,et al.  The serial interval of COVID-19 from publicly reported confirmed cases , 2020, medRxiv.

[9]  A. Osterhaus,et al.  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. , 2012, The New England journal of medicine.

[10]  J. Rocklöv,et al.  COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures , 2020, Journal of travel medicine.

[11]  Neil M. Ferguson,et al.  The effect of public health measures on the 1918 influenza pandemic in U.S. cities , 2007, Proceedings of the National Academy of Sciences.

[12]  R. Mikolajczyk,et al.  Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases , 2008, PLoS medicine.

[13]  Y. Guan,et al.  Coronavirus as a possible cause of severe acute respiratory syndrome , 2003, The Lancet.

[14]  M. Lipsitch,et al.  Public health interventions and epidemic intensity during the 1918 influenza pandemic , 2007, Proceedings of the National Academy of Sciences.

[15]  J. A. Comer,et al.  A novel coronavirus associated with severe acute respiratory syndrome. , 2003, The New England journal of medicine.

[16]  Dylan B. George,et al.  Multiple Estimates of Transmissibility for the 2009 Influenza Pandemic Based on Influenza-like-Illness Data from Small US Military Populations , 2013, PLoS Comput. Biol..