Upper Respiratory Tract Uptake of Acrylate Ester and Acid Vapors

AbstractInhalation exposure of the rodent to either of the esters ethyl acrylate (EA) or methyl methacrylate (MMA) results in nasal olfactory injury. The current study was designed to provide inhalation dosimetric data for these ester vapors as well as for their carboxyl-esterase metabolites, acrylic acid and methacrylic acid. Toward this end, uptake of these vapors was measured in the surgically isolated upper respiratory tract (URT) of the male F344 rat under constant-velocity unidirectional inspiratory (200 mllmin) or cyclic (207 mllmin mean inspiratory flow rate) flow conditions over a wide range of inspired concentrations. To examine the potential influences of carboxylesterase metabolism, uptake of the ester vapors was measured in naive (non-pretreated) rats and in rats pretreated with the carboxylesterase inhibitor bis-nitrophenylphosphate (BNPP). The URT uptake of EA averaged 24, 25, and 18% under cyclic flow at inspired concentrations of approximately 5, 25, and 100 ppm, respectively. Overall, up...

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