Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.

[1]  H. Friess,et al.  15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth. , 2007, Neoplasia.

[2]  Jeffrey S. Morris,et al.  The transcription factor GATA‐6 is overexpressed in vivo and contributes to silencing 15‐LOX‐1 in vitro in human colon cancer , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  M. Tenhunen,et al.  Treatment of prostate cancer with Ad5/3Δ24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo , 2007, Molecular Cancer Therapeutics.

[4]  Jessica E. Bolden,et al.  Anticancer activities of histone deacetylase inhibitors , 2006, Nature Reviews Drug Discovery.

[5]  S. Grösch,et al.  Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. , 2006, Journal of the National Cancer Institute.

[6]  P. Stewart,et al.  Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based upon CAR-Independent Tropism , 2006, Clinical Cancer Research.

[7]  G. Watkins,et al.  Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. , 2006, Prostaglandins, leukotrienes, and essential fatty acids.

[8]  S. Lippman,et al.  Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity , 2006, Oncogene.

[9]  P. Atadja,et al.  The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. , 2006, Molecular pharmacology.

[10]  Jeffrey S. Morris,et al.  The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. , 2005, Cancer research.

[11]  S. Lippman,et al.  Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. , 2005, Cancer research.

[12]  S. Baek,et al.  Overexpression of 15-Lipoxygenase-1 Induces Growth Arrest through Phosphorylation of p53 in Human Colorectal Cancer Cells , 2005, Molecular Cancer Research.

[13]  M. Heslin,et al.  Tumor-Associated Down-Regulation of 15-Lipoxygenase-1 Is Reversed by Celecoxib in Colorectal Cancer , 2005, Annals of surgery.

[14]  S. Lippman,et al.  The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Apoptosis via Induction of 15-Lipoxygenase-1 in Colorectal Cancer Cells , 2004, Cancer Research.

[15]  S. Lowe,et al.  Intrinsic tumour suppression , 2004, Nature.

[16]  D. Curiel,et al.  Transductional targeting of adenoviral cancer gene therapy. , 2004, Current gene therapy.

[17]  P. Cassidy,et al.  Conditional Expression of 15-Lipoxygenase-1 Inhibits the Selenoenzyme Thioredoxin Reductase , 2004, Journal of Biological Chemistry.

[18]  Jeffrey S. Morris,et al.  The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  H. Kuhn,et al.  Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications. , 2002, Prostaglandins & other lipid mediators.

[20]  K. Hunt,et al.  Hurdles and Hopes for Cancer Treatment , 2002, Science.

[21]  J. Douglas,et al.  Targeted adenoviral vectors , 2002 .

[22]  A. Chinnaiyan,et al.  High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer. , 2002, Cancer research.

[23]  S. Lippman,et al.  Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. , 2001, Cancer research.

[24]  H. Niiyama,et al.  Quantitative analysis of hTERT mRNA expression in colorectal cancer , 2001, American Journal of Gastroenterology.

[25]  J. Lebkowski,et al.  The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters , 2001, Gene Therapy.

[26]  K. Brand,et al.  Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue. , 2000, Cancer research.

[27]  J. Gu,et al.  Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. , 2000, Cancer research.

[28]  S. Lippman,et al.  15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. , 2000, Journal of the National Cancer Institute.

[29]  C. Englert,et al.  Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. , 2000, Cancer research.

[30]  J. Gibbs.  Mechanism-based target identification and drug discovery in cancer research. , 2000, Science.

[31]  S. Grant,et al.  Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53 , 1999, Oncogene.

[32]  I. Shureiqi,et al.  Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. , 1999, Carcinogenesis.

[33]  M. Yutsudo,et al.  Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. , 1999, Cancer research.

[34]  J C Reed,et al.  IAP family proteins--suppressors of apoptosis. , 1999, Genes & development.

[35]  C. Miller,et al.  An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism , 1998, Journal of Virology.

[36]  H. Kamitani,et al.  Expression of 15-Lipoxygenase by Human Colorectal Carcinoma Caco-2 Cells during Apoptosis and Cell Differentiation* , 1998, The Journal of Biological Chemistry.

[37]  F. Itoh,et al.  [Regulation of integrin function in the metastasis of colorectal cancer]. , 1998, Nihon Geka Gakkai zasshi.

[38]  F. Marshall,et al.  The national cancer data base , 1997, Cancer.

[39]  A. Brash,et al.  Discovery of a second 15S-lipoxygenase in humans. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[40]  D. Winchester,et al.  The National Cancer Data Base report on colon cancer , 1996, Cancer.

[41]  C B Harley,et al.  Specific association of human telomerase activity with immortal cells and cancer. , 1994, Science.

[42]  C. Thompson,et al.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death , 1993, Cell.

[43]  W. Bodmer,et al.  p53 mutations in colorectal cancer. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[44]  T. Eling,et al.  15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.

[45]  D. Curiel,et al.  Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[46]  B. Fang,et al.  hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity , 2002, Gene Therapy.

[47]  S. Woo,et al.  Gene therapy of metastatic colon carcinoma: Regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase , 2000, Cancer Gene Therapy.

[48]  J. Roth,et al.  Evaluation of GAL4/TATA in Vivo INDUCTION OF TRANSGENE EXPRESSION BY ADENOVIRALLY MEDIATED GENE CODELIVERY* , 1998 .

[49]  J. Hardcastle,et al.  Colorectal cancer , 1993, Europe Against Cancer European Commission Series for General Practitioners.