F. Admiraal Behloul, H. Olofsen, D. M. van den Heuvel, N. Schmitz, J. H. Reiber, M. A. van Buchem Radiology, Leiden University Medical Center, Leiden, Netherlands Introduction White matter abnormalities often referred to as “hyperintensities” in MRI have been investigated in older adults for their role in normal aging, dementia and late-onset depression. Previously, [1] we developed an accurate semi-automated method to quantify WML load which has been successfully used in a large study in geriatric subjects and produced clinically relevant results [2]. The main goal of the present work was to develop a software tool that allows a more local analysis of WMHI load in anatomical regions (lobes and cerebellum), for correlation analyses with cognitive information in geriatric patients. We aimed at a relatively coarse lobe delineation (see fig1.a and fig.2b).