Reappraising the phototoxicity of tretinoin: a report of four controlled clinical trials

Background: Retinoids are photoreactive molecules found in skin and retinal tissue. The use of retinoids in pharmacologic doses, applied topically, raises the potential of phototoxicities. Recent review articles and current US drug labeling indicate that tretinoin is a phototoxin. In developing a new formulation of topical all‐trans‐retinoic acid (tretinoin), formal testing of dermal photoreactions was therefore undertaken.

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