Dual-function transcription factors and their entourage

Much of what we, as plant molecular biologists studying gene regulation, know comes from paradigms characterized or developed in mammalian systems. Although plants, animals, and fungi have been diverging for a very long time, a great deal of the machineries and components discovered in yeast and mammals seem to have been maintained in plants. Nevertheless, despite this apparent conservation, evolutionary pressures on the mechanisms of gene regulation are likely to be different between these kingdoms, given their different environmental constraints. As such, it is imperative for plant molecular biologists to develop their own paradigms, even on seemingly conserved systems. It is with this intent that we compare and contrast the regulation of two pathogenesis-related genes, the arabidopsis PR-1 and potato PR-10a genes. The transcription factors regulating these genes present prime paradigms for the study of plant signal- and context-dependent dual-function transcription factors.

[1]  Patrick J. Boyle,et al.  The BTB/POZ Domain of the Arabidopsis Disease Resistance Protein NPR1 Interacts with the Repression Domain of TGA2 to Negate Its Function[W] , 2009, The Plant Cell Online.

[2]  D. Klessig,et al.  Salicylic Acid, a multifaceted hormone to combat disease. , 2009, Annual review of phytopathology.

[3]  P. Genschik,et al.  Proteasome-Mediated Turnover of the Transcription Coactivator NPR1 Plays Dual Roles in Regulating Plant Immunity , 2009, Cell.

[4]  F. Takken,et al.  Does chromatin remodeling mark systemic acquired resistance? , 2009, Trends in plant science.

[5]  F. Daayf,et al.  Disease resistance in Arabidopsis, starring TGA2 and also featuring NPR1. , 2009 .

[6]  C. Després,et al.  The Transcriptional Activator Pti4 Is Required for the Recruitment of a Repressosome Nucleated by Repressor SEBF at the Potato PR-10a Gene[W] , 2008, The Plant Cell Online.

[7]  C. Gatz,et al.  The Arabidopsis GRAS Protein SCL14 Interacts with Class II TGA Transcription Factors and Is Essential for the Activation of Stress-Inducible Promoters[C][W] , 2008, The Plant Cell Online.

[8]  C. Pieterse,et al.  Histone modifications do not play a major role in salicylate-mediated suppression of jasmonate-induced PDF1.2 gene expression , 2008, Communicative & integrative biology.

[9]  D. Arnosti,et al.  Spreading of a Corepressor Linked to Action of Long-Range Repressor Hairy , 2008, Molecular and Cellular Biology.

[10]  C. Després,et al.  The Transcriptional Activator Pti 4 Is Required for the Recruitment of a Repressosome Nucleated by Repressor SEBF at the Potato PR-10 a Gene , 2008 .

[11]  G. Gill,et al.  Regulation of the dual-function transcription factor Sp3 by SUMO. , 2007, Biochemical Society transactions.

[12]  Nathaniel D. Heintzman,et al.  The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome , 2007, Cellular and Molecular Life Sciences.

[13]  Patrick J. Boyle,et al.  The Coactivator Function of Arabidopsis NPR1 Requires the Core of Its BTB/POZ Domain and the Oxidation of C-Terminal Cysteines[W] , 2006, The Plant Cell Online.

[14]  Uwe Conrath,et al.  Systemic Acquired Resistance , 2006, Plant signaling & behavior.

[15]  R. Mosher,et al.  A Comprehensive Structure–Function Analysis of Arabidopsis SNI1 Defines Essential Regions and Transcriptional Repressor Activity[W][OA] , 2006, The Plant Cell Online.

[16]  C. Glass,et al.  Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. , 2006, Genes & development.

[17]  C. Lamb,et al.  Systemic immunity. , 2006, Current opinion in plant biology.

[18]  D. Klessig,et al.  Salicylic acid-inducible Arabidopsis CK2-like activity phosphorylates TGA2 , 2005, Plant Molecular Biology.

[19]  Jun Ma,et al.  Crossing the line between activation and repression. , 2005, Trends in genetics : TIG.

[20]  Gioacchino Natoli,et al.  Little Things that Count in Transcriptional Regulation , 2004, Cell.

[21]  J. Dangl,et al.  A "Whirly" transcription factor is required for salicylic acid-dependent disease resistance in Arabidopsis. , 2004, Developmental cell.

[22]  A. Leutz,et al.  Ras induces mediator complex exchange on C/EBP beta. , 2004, Molecular cell.

[23]  N. Brisson,et al.  Identification of cis-acting elements involved in the regulation of the pathogenesis-related gene STH-2 in potato , 1993, Plant Molecular Biology.

[24]  Xin Li,et al.  Knockout Analysis of Arabidopsis Transcription Factors TGA2, TGA5, and TGA6 Reveals Their Redundant and Essential Roles in Systemic Acquired Resistance Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.014894. , 2003, The Plant Cell Online.

[25]  Thomas Mitchell-Olds,et al.  Faculty Opinions recommendation of Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis. , 2003 .

[26]  T. L. Graham,et al.  Induced expression of pathogenesis-related protein genes in soybean by wounding and the Phytophthora sojae cell wall glucan elicitor , 2003 .

[27]  J. Ostrowski,et al.  Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci. , 2003, Nucleic acids research.

[28]  S. Yoshida,et al.  A diterpene as an endogenous signal for the activation of defense responses to infection with tobacco mosaic virus and wounding in tobacco. , 2001, The Plant cell.

[29]  Xinnian Dong,et al.  In Vivo Interaction between NPR1 and Transcription Factor TGA2 Leads to Salicylic Acid–Mediated Gene Activation in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.001628. , 2002, The Plant Cell Online.

[30]  G. Martin,et al.  Tomato Transcription Factors Pti4, Pti5, and Pti6 Activate Defense Responses When Expressed in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000794. , 2002, The Plant Cell Online.

[31]  Leszek Rychlewski,et al.  Heterogeneous Nuclear Ribonucleoprotein K Protein Associates with Multiple Mitochondrial Transcripts within the Organelle* , 2002, The Journal of Biological Chemistry.

[32]  Keqiang Wu,et al.  Functional analysis of tomato Pti4 in Arabidopsis. , 2002, Plant physiology.

[33]  J U Bowie,et al.  Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression , 2001, The EMBO journal.

[34]  D S Latchman,et al.  Transcription factors: bound to activate or repress. , 2001, Trends in biochemical sciences.

[35]  B. Boyle,et al.  Repression of the defense gene PR-10a by the single-stranded DNA binding protein SEBF. , 2001, The Plant cell.

[36]  D. Desveaux,et al.  PBF-2 Is a Novel Single-Stranded DNA Binding Factor Implicated in PR-10a Gene Activation in Potato , 2000, Plant Cell.

[37]  G. Martin,et al.  Pti4 Is Induced by Ethylene and Salicylic Acid, and Its Product Is Phosphorylated by the Pto Kinase , 2000, Plant Cell.

[38]  Enwu Liu,et al.  The Arabidopsis NPR1/NIM1 Protein Enhances the DNA Binding Activity of a Subgroup of the TGA Family of bZIP Transcription Factors , 2000, Plant Cell.

[39]  J. Downing,et al.  Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein , 1999, Molecular and Cellular Biology.

[40]  Xin Li,et al.  Identification and Cloning of a Negative Regulator of Systemic Acquired Resistance, SNI1, through a Screen for Suppressors of npr1-1 , 1999, Cell.

[41]  P. Heifetz,et al.  Functional analysis of regulatory sequences controlling PR-1 gene expression in Arabidopsis. , 1998, The Plant journal : for cell and molecular biology.

[42]  Xin Li,et al.  Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[43]  G. Martin,et al.  The Pto kinase conferring resistance to tomato bacterial speck disease interacts with proteins that bind a cis‐element of pathogenesis‐related genes , 1997, The EMBO journal.

[44]  C. Després,et al.  The Activation of the Potato PR-10a Gene Requires the Phosphorylation of the Nuclear Factor PBF-1. , 1995, The Plant cell.

[45]  J. A. Ryals,et al.  Coordinate Gene Activity in Response to Agents That Induce Systemic Acquired Resistance. , 1991, The Plant cell.

[46]  J. Ostrowski,et al.  A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element. , 1991, The Journal of biological chemistry.

[47]  G. Dreyfuss,et al.  Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities , 1988, Molecular and cellular biology.