Theranostic applications of nanoparticles in cancer.

Nanoparticles are the moieties that have undergone the most investigation in recent years for biomedical applications. They are applied in the field of oncology in the same way as in other branches of biomedical nanotechnology. Regarding cancer, nanoparticles, and especially magnetic nanoparticles, are studied for diagnosis, drug delivery, gene delivery, bioseparation, hyperthermia, phototherapy, chemotherapy, imaging mechanisms, among other uses. Different techniques are used to prepare multifunctional nanoparticles and modify nanoparticle surfaces required for different applications. This review focuses on the basic theranostic approach, the different materials used in theranostics, theranostic applications and future directions based on recent developments in these areas.

[1]  R. Westervelt,et al.  Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres. , 2008, ACS nano.

[2]  Aniruddh Solanki,et al.  Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging. , 2008, Nanomedicine.

[3]  In Su Lee,et al.  Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[4]  Qiang Wang,et al.  Polyhydroxy fullerenes for non-invasive cancer imaging and therapy. , 2010, Small.

[5]  Baowei Fei,et al.  Highly efficient drug delivery with gold nanoparticle vectors for in vivo photodynamic therapy of cancer. , 2008, Journal of the American Chemical Society.

[6]  P. Nordlander,et al.  Magnetic-plasmonic core-shell nanoparticles. , 2009, ACS nano.

[7]  S. Nie,et al.  In vivo cancer targeting and imaging with semiconductor quantum dots , 2004, Nature Biotechnology.

[8]  Tuan Vo-Dinh,et al.  Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation: a potential nanoplatform for theranostics. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[9]  Indrajit Roy,et al.  Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. , 2003, Journal of the American Chemical Society.

[10]  Zhuang Liu,et al.  Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. , 2005, Journal of the American Chemical Society.

[11]  Xin Gao,et al.  Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy. , 2011, Biomaterials.

[12]  T. Minko,et al.  Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[13]  I. Chourpa,et al.  Nanovectors for anticancer agents based on superparamagnetic iron oxide nanoparticles , 2007, International journal of nanomedicine.

[14]  C. Park,et al.  Multifunctional poly(aspartic acid) nanoparticles containing iron oxide nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy , 2011 .

[15]  Chenjie Xu,et al.  Porous hollow Fe(3)O(4) nanoparticles for targeted delivery and controlled release of cisplatin. , 2009, Journal of the American Chemical Society.

[16]  G. Salazar-Alvarez,et al.  Mesoporous silica–magnetite nanocomposite synthesized by using a neutral surfactant , 2008, Nanotechnology.

[17]  Eric D. Pressly,et al.  A Simple Route to Multimodal Composite Nanoparticles , 2009 .

[18]  Zhuang Liu,et al.  Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. , 2011, Biomaterials.

[19]  Juan L. Vivero-Escoto,et al.  Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. , 2009, Journal of the American Chemical Society.

[20]  Kai Chen,et al.  PET/NIRF/MRI triple functional iron oxide nanoparticles. , 2010, Biomaterials.

[21]  Weiwei Guo,et al.  Anticancer drug-DNA interactions measured using a photoinduced electron-transfer mechanism based on luminescent quantum dots. , 2009, Analytical chemistry.

[22]  Jinwoo Cheon,et al.  All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. , 2009, Angewandte Chemie.

[23]  M. Prato,et al.  Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. , 2005, Journal of the American Chemical Society.

[24]  Forrest M Kievit,et al.  Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery. , 2011, Biomaterials.

[25]  C. Labrugère,et al.  Sonochemical approach to the synthesis of Fe(3)O(4)@SiO(2) core-shell nanoparticles with tunable properties. , 2008, ACS nano.

[26]  Sangjin Park,et al.  Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. , 2008, Angewandte Chemie.

[27]  Victor S-Y Lin,et al.  Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles. , 2005, Angewandte Chemie.

[28]  Hongjie Dai,et al.  siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. , 2007, Angewandte Chemie.

[29]  Michael J Sailor,et al.  Biodegradable luminescent porous silicon nanoparticles for in vivo applications. , 2009, Nature materials.

[30]  Kai Yang,et al.  Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles , 2012, Advanced materials.

[31]  M. Gao,et al.  Magnetic Janus Particles Prepared by a Flame Synthetic Approach: Synthesis, Characterizations and Properties , 2009 .

[32]  Srikanth Pilla,et al.  Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery. , 2009, Biomaterials.

[33]  Taeghwan Hyeon,et al.  Wrap-bake-peel process for nanostructural transformation from beta-FeOOH nanorods to biocompatible iron oxide nanocapsules. , 2008, Nature materials.

[34]  Chris A Flask,et al.  Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. , 2008, Biomaterials.

[35]  Maurizio Prato,et al.  Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. , 2008, Chemical communications.

[36]  Jin Kuk Kim,et al.  Microstructural investigations of zirconium oxide—on core–shell structure of carbon nanotubes , 2011 .

[37]  M. Prato,et al.  Functionalized carbon nanotubes for plasmid DNA gene delivery. , 2004, Angewandte Chemie.

[38]  Hao Hong,et al.  cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. , 2011, Biomaterials.

[39]  Dar-Bin Shieh,et al.  Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles. , 2009, Journal of the American Chemical Society.

[40]  E. Zubarev,et al.  Paclitaxel-functionalized gold nanoparticles. , 2007, Journal of the American Chemical Society.

[41]  R. Tilton,et al.  Stabilization of superparamagnetic iron oxide core-gold shell nanoparticles in high ionic strength media. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[42]  Georgios A Sotiriou,et al.  Hybrid, silica-coated, Janus-like plasmonic-magnetic nanoparticles. , 2011, Chemistry of materials : a publication of the American Chemical Society.

[43]  H. Dai,et al.  Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery , 2009, Nano research.

[44]  Chun Li,et al.  Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide-Silica Core Suitable for Both MR Imaging and Photothermal Therapy. , 2007, The journal of physical chemistry. C, Nanomaterials and interfaces.

[45]  Jinming Gao,et al.  Theranostic nanomedicine for cancer. , 2008, Nanomedicine.

[46]  Daxiang Cui,et al.  Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. , 2011, Biomaterials.

[47]  Zhuang Liu,et al.  Drug delivery with carbon nanotubes for in vivo cancer treatment. , 2008, Cancer research.

[48]  Mingyuan Gao,et al.  One-Pot Reaction to Synthesize Water-Soluble Magnetite Nanocrystals , 2004 .

[49]  Naomi J Halas,et al.  A Molecularly Targeted Theranostic Probe for Ovarian Cancer , 2010, Molecular Cancer Therapeutics.

[50]  Superparamagnetic Gadonanotubes Are High-Performance MRI Contrast Agents. , 2005 .

[51]  Forrest M Kievit,et al.  Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[52]  Jinwoo Cheon,et al.  Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging , 2007, Nature Medicine.

[53]  Jin-Sil Choi,et al.  In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. , 2005, Journal of the American Chemical Society.

[54]  Hatem Fessi,et al.  Modified double emulsion process as a new route to prepare submicron biodegradable magnetic/polycaprolactone particles for in vivo theranostics , 2012 .

[55]  Susan Warner,et al.  Diagnostics + therapy = theranostics , 2004 .

[56]  R. Stafford,et al.  Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. , 2011, Biomaterials.

[57]  Erkki Ruoslahti,et al.  Targeted quantum dot conjugates for siRNA delivery. , 2007, Bioconjugate chemistry.

[58]  C. R. Mayer,et al.  Gold nanoparticles functionalized with gadolinium chelates as high-relaxivity MRI contrast agents. , 2009, Journal of the American Chemical Society.

[59]  Shaoqin Gong,et al.  Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. , 2010, Biomaterials.

[60]  Xiaohu Gao,et al.  Emerging application of quantum dots for drug delivery and therapy. , 2008, Expert opinion on drug delivery.

[61]  T. Park,et al.  Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. , 2011, Biomaterials.

[62]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[63]  E. Lukianova-Hleb,et al.  Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles. , 2011, The Journal of surgical research.

[64]  Y. Yoshioka,et al.  Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery. , 2009, Biomaterials.

[65]  Robert Langer,et al.  Quantum dot-aptamer conjugates for synchronous cancer imaging and therapy based on bi-fluorescence resonance energy transfer , 2007 .

[66]  Miqin Zhang,et al.  Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[67]  Jeffrey I. Zink,et al.  Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery , 2010, BiOS.

[68]  Paras N Prasad,et al.  Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. , 2007, Journal of the American Chemical Society.