Ocular rigidity: biomechanical role, in vivo measurements and clinical significance

Ocular rigidity (OR) refers to the relationship between pressure and volume changes in the eyeball. Since the description of the differential tonometry method for the calculation of an OR coefficient by Friedenwald, several other methodologies have been proposed to measure OR, including the anterior chamber manometry, axial length (AL) changes, measurement of pulse amplitude and fundus pulse, ultrasound elastography and evaluation of corneal hysteresis. However, most of these methodologies suffer from deficiencies, such as invasive nature, poor accuracy or reproducibility or technical complexity. Nevertheless, it is possible that OR affects the pathogenesis and clinical course of a variety of ocular conditions, including glaucoma, age‐related macular degeneration, presbyopia, corneal changes following refractive surgery as well as the accuracy of IOP measurements by many tonometers. Thus, the future development of non‐invasive and easy‐to‐use methodologies for the accurate measurement of OR in the every‐day practice would be clinically important.

[1]  J. Lace,et al.  A comparison of the elastic properties of human choroid and sclera. , 1988, Experimental eye research.

[2]  A. Ebneter,et al.  Non-invasive biometric assessment of ocular rigidity in glaucoma patients and controls , 2009, Eye.

[3]  M. Tsilimbaris,et al.  Ocular rigidity in patients with age-related macular degeneration. , 2006, American journal of ophthalmology.

[4]  M. Tsilimbaris,et al.  Differences between Goldmann Applanation Tonometry and Dynamic Contour Tonometry in pseudoexfoliation syndrome , 2010, Clinical & experimental ophthalmology.

[5]  M. Langham,et al.  The relationship between pressure and volume changes in living and dead rabbit eyes. , 1962, Investigative ophthalmology.

[6]  C Ross Ethier,et al.  Scleral biomechanics and glaucoma--a connection? , 2006, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[7]  I. Floriani,et al.  Dynamic Contour Tonometry and Goldmann Applanation Tonometry: Correlation with Intracameral Assessment of Intraocular Pressure , 2012, European journal of ophthalmology.

[8]  S. Azen,et al.  Effects of corneal thickness, corneal curvature, and intraocular pressure level on Goldmann applanation tonometry and dynamic contour tonometry. , 2007, Ophthalmology.

[9]  D. Sharma,et al.  Scleral rigidity in glaucoma, before and during topical antiglaucoma drug therapy. , 1991, Indian journal of ophthalmology.

[10]  M. Tsilimbaris,et al.  Applanation Tonometry Versus Dynamic Contour Tonometry in Eyes Treated With Latanoprost , 2010, Journal of glaucoma.

[11]  E. Pitchon.  How to measure the whole ocular rigidity? , 2006, American journal of ophthalmology.

[12]  E. Friedman.  Update of the vascular model of AMD , 2004, British Journal of Ophthalmology.

[13]  Suk-tak Chan,et al.  The Effect of Age on Ocular Blood Supply Determined by Pulsatile Ocular Blood Flow and Color Doppler Ultrasonography , 2003, Optometry and vision science : official publication of the American Academy of Optometry.

[14]  Xiangjun Yang,et al.  Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. , 2007, Investigative ophthalmology & visual science.

[15]  C. Roberts,et al.  A viscoelastic biomechanical model of the cornea describing the effect of viscosity and elasticity on hysteresis. , 2008, Investigative ophthalmology & visual science.

[16]  J. Friedenwald.  Clinical significance of ocular rigidity in relation to the tonometric measurement. , 1949, Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology.

[17]  H. Goldmann,et al.  [Applanation tonometry]. , 1957, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[18]  G. Mangouritsas,et al.  Comparison of Goldmann and Pascal tonometry in relation to corneal hysteresis and central corneal thickness in nonglaucomatous eyes , 2011, Clinical ophthalmology.

[19]  H. H. Mark,et al.  Corneal curvature in applanation tonometry. , 1973, American journal of ophthalmology.

[20]  Ian A Sigal,et al.  Biomechanics of the optic nerve head. , 2009, Experimental eye research.

[21]  S. Drance.  The coefficient of scleral rigidity in normal and glaucomatous eyes. , 1960, Archives of ophthalmology.

[22]  B K Pierscionek,et al.  The effect of changing intraocular pressure on the corneal and scleral curvatures in the fresh porcine eye , 2006, British Journal of Ophthalmology.

[23]  M. Tsilimbaris,et al.  Real-time ultrasound elastographic imaging of ocular and periocular tissues: a feasibility study. , 2010, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[24]  Shan C. Lin,et al.  Tonometry through the ages. , 2008, Survey of ophthalmology.

[25]  D. Gaasterland,et al.  Studies of aqueous humour dynamics in man. VI. Effect of age upon parameters of intraocular pressure in normal human eyes. , 1978, Experimental eye research.

[26]  M. Tsilimbaris,et al.  Ocular rigidity in living human eyes. , 2005, Investigative ophthalmology & visual science.

[27]  F. Foster,et al.  Use of microbubble ultrasound contrast agent to demonstrate the iris valve effect in human eye bank eyes. , 1998, American journal of ophthalmology.

[28]  A. Tomlinson,et al.  Applanation tension and axial length of the eyeball. , 1970, The British journal of ophthalmology.

[29]  S. Senthil,et al.  Misleading Goldmann applanation tonometry in a post-LASIK eye with interface fluid syndrome , 2010, Indian journal of ophthalmology.

[30]  Ahmed Elsheikh,et al.  Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer. , 2006, Investigative ophthalmology & visual science.

[31]  Leopold Schmetterer,et al.  Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma. , 2008, Investigative ophthalmology & visual science.

[32]  G. Ravalico,et al.  Age-related ocular blood flow changes. , 1996, Investigative ophthalmology & visual science.

[33]  J. Downs,et al.  Changes in the biomechanical response of the optic nerve head in early experimental glaucoma. , 2010, Investigative ophthalmology & visual science.

[34]  J. García-Feijóo,et al.  [Comparison of Goldmann applanation and dynamic contour tonometry measurements: effects of corneal morphometry]. , 2011, Archivos de la Sociedad Espanola de Oftalmologia.

[35]  T. Krouskop,et al.  Poroelastography: imaging the poroelastic properties of tissues. , 2001, Ultrasound in medicine & biology.

[36]  J. Friedenwald.  Tonometer calibration; an attempt to remove discrepancies found in the 1954 calibration scale for Schiotz tonometers. , 1957, Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology.

[37]  M. Langham,et al.  MANOMETRIC STUDIES OF THE PRESSURE–VOLUME RELATIONSHIP IN LIVING AND ENUCLEATED EYES OF INDIVIDUAL HUMAN SUBJECTS*† , 1962, The British journal of ophthalmology.

[38]  Christine T. O. Nguyen,et al.  Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing aqueous outflow. , 2007, Investigative ophthalmology & visual science.

[39]  J Seddon,et al.  Increased scleral rigidity and age-related macular degeneration. , 1989, Ophthalmology.

[40]  Shan C. Lin,et al.  Dynamic contour tonometry: principle and use , 2006, Clinical & experimental ophthalmology.

[41]  P. Kaufman,et al.  Accommodation and presbyopia: the ciliary neuromuscular view. , 2006, Ophthalmology clinics of North America.

[42]  A. Tomlinson,et al.  Ocular tension and axial length of the eyeball in open-angle glaucoma and low tension glaucoma. , 1973, The British journal of ophthalmology.

[43]  B Gilmartin,et al.  The aetiology of presbyopia: a summary of the role of lenticular and extralenticular structures. , 1995, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[44]  M. Abdalla,et al.  Applanation ocular tension in myopia and emmetropia. , 1970, The British journal of ophthalmology.

[45]  L. Schmetterer,et al.  Effects of acetazolamide on choroidal blood flow. , 1998, Stroke.

[46]  B. Garra,et al.  AN OVERVIEW OF ELASTOGRAPHY - AN EMERGING BRANCH OF MEDICAL IMAGING. , 2011, Current medical imaging reviews.

[47]  W N Charman,et al.  Accommodation responses and ageing. , 1999, Investigative ophthalmology & visual science.

[48]  I. Cunliffe,et al.  Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. , 2007, Investigative ophthalmology & visual science.

[49]  Vinod Kumar Gupta,et al.  Systemic hypertension, headache, and ocular hemodynamics: a new hypothesis. , 2006, MedGenMed : Medscape general medicine.

[50]  N. Ehlers,et al.  APPLANATION TONOMETRY AND CENTRAL CORNEAL THICKNESS , 1975, Acta ophthalmologica.

[51]  M. Tsilimbaris,et al.  Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of intraocular pressure. , 2009, Investigative ophthalmology & visual science.

[52]  J. Pulido.  Scleral rigidity and macular degeneration: pathophysiologic or epiphenomenon? , 2006, American journal of ophthalmology.

[53]  H. H. Mark,et al.  Axial length in applanation tonometry , 2002, Journal of cataract and refractive surgery.