Rare Coexistence of Fabry Disease with Class V Membranous Lupus Nephritis

Fabry disease (FD) is a rare X-linked inherited disorder resulting from deficient α-galactosidase A enzymatic activity due to pathogenic mutations in the α-galactosidase A (GLA) gene [1]. This leads to progressive lysosomal globotriaosylceramide (Gb3) accumulation in a variety of cell types, including vascular endothelial and smooth muscle cells, myocytes and podocytes and other kidney cell types [1].