Thermoacoustic Imaging of Breast Cancer: A Phantom Study

Towards clinical application for breast cancer detection, phantom experiments were conducted to optimize our thermoacoustic imaging (TAI) system. We compared the imaging performance of the conventional horn antenna (HA)-based and a new handheld dipole antenna (HDA)-based TAI systems. We determined that the HAD-based TAI outperformed the HA-based TAI. We then conducted experiments to determine the best angle of the HAD relative to a breast-shaped phantom, and found that the best image quality was obtained when the angle was 90 degrees.

[1]  Hua-bei Jiang,et al.  Label-free thermoacoustic imaging of human blood vessels in vivo , 2018, Applied Physics Letters.

[2]  En Li,et al.  A broadband variable-temperature test system for complex permittivity measurements of solid and powder materials. , 2018, The Review of scientific instruments.

[3]  Qing Huo Liu,et al.  Mitigating acoustic heterogeneous effects in microwave-induced breast thermoacoustic tomography using multi-physical K-means clustering , 2017 .

[4]  Lihong V. Wang,et al.  Homogenizing microwave illumination in thermoacoustic tomography by a linear-to-circular polarizer based on frequency selective surfaces , 2017 .

[5]  Hua-bei Jiang,et al.  Technical Note: Thermoacoustic imaging of hemorrhagic stroke: A feasibility study with a human skull , 2017, Medical physics.

[6]  Hao Nan,et al.  Peak-Power-Limited Frequency-Domain Microwave-Induced Thermoacoustic Imaging for Handheld Diagnostic and Screening Tools , 2017, IEEE Transactions on Microwave Theory and Techniques.

[7]  Fei Gao,et al.  Advanced photoacoustic and thermoacoustic sensing and imaging beyond pulsed absorption contrast , 2016 .

[8]  Da Xing,et al.  Ultrashort Microwave-Pumped Real-Time Thermoacoustic Breast Tumor Imaging System , 2016, IEEE Transactions on Medical Imaging.

[9]  W. See,et al.  Toward Quantitative Whole Organ Thermoacoustics With a Clinical Array Plus One Very Low-Frequency Channel Applied to Prostate Cancer Imaging , 2016, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[10]  S. Andleeb,et al.  Blueprint of quartz crystal microbalance biosensor for early detection of breast cancer through salivary autoantibodies against ATP6AP1. , 2015, Biosensors & bioelectronics.

[11]  Yuanjin Zheng,et al.  Magnetically mediated thermoacoustic imaging toward deeper penetration , 2013 .

[12]  Hao Xin,et al.  Microwave-Induced Thermoacoustic Imaging Model for Potential Breast Cancer Detection , 2012, IEEE Transactions on Biomedical Engineering.

[13]  N. Nikolova.  Microwave Imaging for Breast Cancer , 2011, IEEE Microwave Magazine.

[14]  Vasilis Ntziachristos,et al.  Near-field radiofrequency thermoacoustic tomography with impulse excitation. , 2010, Medical physics.

[15]  Lihong V. Wang,et al.  Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography. , 2008, Medical physics.

[16]  Yuan Xu,et al.  Rhesus monkey brain imaging through intact skull with thermoacoustic tomography , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[17]  Massimo Bazzocchi,et al.  Sensitivity of MRI versus mammography for detecting foci of multifocal, multicentric breast cancer in Fatty and dense breasts using the whole-breast pathologic examination as a gold standard. , 2004, AJR. American journal of roentgenology.

[18]  J. Weyler,et al.  MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue: comparison with mammography and ultrasound , 2004, European Radiology.

[19]  Marcus Schmidt,et al.  Preoperative assessment of breast cancer: sonography versus MR imaging. , 2002, AJR. American journal of roentgenology.

[20]  A. Tam.  Applications of photoacoustic sensing techniques , 1986 .

[21]  S. Bipat,et al.  # The Author(s) 2009 This article is published with open access at Springerlink.com , 2008 .