ABERRANT REWARD CENTER RESPONSE TO PARTNER REPUTATION DURING A SOCIAL EXCHANGE GAME IN GENERALIZED SOCIAL PHOBIA

Generalized social anxiety disorder (GSAD) is characterized by excessive fear of public scrutiny and reticence in social engagement. Previous studies have probed the neural basis of GSAD often using static, noninteractive stimuli (e.g., face photographs) and have identified dysfunction in fear circuitry. We sought to investigate brain‐based dysfunction in GSAD during more real‐world, dynamic social interactions, focusing on the role of reward‐related regions that are implicated in social decision‐making.

[1]  W. Schultz.  Multiple reward signals in the brain , 2000, Nature Reviews Neuroscience.

[2]  R. Dolan,et al.  Brain Responses to the Acquired Moral Status of Faces , 2004, Neuron.

[3]  N. Amir,et al.  Attentional bias to threat in social phobia: facilitated processing of threat or difficulty disengaging attention from threat? , 2003, Behaviour research and therapy.

[4]  P. Richerson,et al.  The evolution of indirect reciprocity , 1989 .

[5]  D. Clark,et al.  Information-processing bias in social phobia. , 2004, Clinical psychology review.

[6]  K. Berridge,et al.  Parsing reward , 2003, Trends in Neurosciences.

[7]  C. Dancu,et al.  Physiological, cognitive and behavioral aspects of social anxiety. , 1985, Behaviour research and therapy.

[8]  P. Philippot,et al.  Selective attention to angry faces in clinical social phobia. , 2004, Journal of abnormal psychology.

[9]  R. Kessler,et al.  Social fears and social phobia in the USA: results from the National Comorbidity Survey Replication , 2007, Psychological Medicine.

[10]  F. Strack,et al.  TARGET ARTICLE: Duality Models in Social Psychology: From Dual Processes to Interacting Systems , 2006 .

[11]  Matthew D. Lieberman,et al.  Fairness and Cooperation Are Rewarding , 2007, Annals of the New York Academy of Sciences.

[12]  C. Sripada,et al.  Reputation for reciprocity engages the brain reward center , 2010, Proceedings of the National Academy of Sciences.

[13]  J. O'Doherty,et al.  Predictive Neural Coding of Reward Preference Involves Dissociable Responses in Human Ventral Midbrain and Ventral Striatum , 2006, Neuron.

[14]  Israel Liberzon,et al.  Functional neuroimaging of mentalizing during the trust game in social anxiety disorder , 2009, Neuroreport.

[15]  Joseph Henrich,et al.  Cultural Evolution of Human Cooperation , 2002 .

[16]  Dominic S. Fareri,et al.  Social Network Modulation of Reward-Related Signals , 2012, The Journal of Neuroscience.

[17]  Murray B. Stein,et al.  Striatal Function in Generalized Social Phobia: A Functional Magnetic Resonance Imaging Study , 2007, Biological Psychiatry.

[18]  D. Clark,et al.  Social phobia and interpretation of social events. , 2000, Behaviour research and therapy.

[19]  B. King-Casas,et al.  The Rupture and Repair of Cooperation in Borderline Personality Disorder , 2008, Science.

[20]  Luke J. Chang,et al.  Effects of Direct Social Experience on Trust Decisions and Neural Reward Circuitry , 2012, Front. Neurosci..

[21]  P. Montague,et al.  Neural Economics and the Biological Substrates of Valuation , 2002, Neuron.

[22]  B. King-Casas,et al.  The neurobiology of social decision-making , 2008, Current Opinion in Neurobiology.

[23]  Mike Mesterton-Gibbons,et al.  Genetic and cultural evolution of cooperation , 2004 .

[24]  N. Fox,et al.  Neural Correlates of Reward Processing in Adolescents With a History of Inhibited Temperament , 2009, Psychological science.

[25]  Colin Camerer,et al.  Social neuroeconomics: the neural circuitry of social preferences , 2007, Trends in Cognitive Sciences.

[26]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[27]  Dan J Stein,et al.  Social Anxiety Disorder , 1999, CNS Spectrums.

[28]  D. Kaloupek,et al.  Evaluation of a clinically relevant target behavior for analog outcome research , 1974 .

[29]  J. O'Doherty,et al.  Reward representations and reward-related learning in the human brain: insights from neuroimaging , 2004, Current Opinion in Neurobiology.

[30]  Peter Dayan,et al.  A Neural Substrate of Prediction and Reward , 1997, Science.

[31]  Michael G. Hardin,et al.  Reward and punishment sensitivity in shy and non-shy adults: Relations between social and motivated behavior. , 2006, Personality and individual differences.

[32]  Michael G. Hardin,et al.  Striatal Functional Alteration in Adolescents Characterized by Early Childhood Behavioral Inhibition , 2006, The Journal of Neuroscience.

[33]  Charles T. Taylor,et al.  Interpersonal processes in social phobia. , 2004, Clinical psychology review.

[34]  M. Delgado,et al.  Perceptions of moral character modulate the neural systems of reward during the trust game , 2005, Nature Neuroscience.

[35]  A. Etkin,et al.  Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. , 2007, The American journal of psychiatry.

[36]  S. Quartz,et al.  Getting to Know You: Reputation and Trust in a Two-Person Economic Exchange , 2005, Science.

[37]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[38]  N. Kriegeskorte,et al.  Neural correlates of trust , 2007, Proceedings of the National Academy of Sciences.

[39]  E. Gilboa-Schechtman,et al.  Memory bias in generalized social phobia: remembering negative emotional expressions. , 2000, Journal of anxiety disorders.

[40]  D. Clark,et al.  Information processing in social phobia , 2002, Biological Psychiatry.