Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue

[1]  J. Shelhamer,et al.  Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages , 2015, The Journal of Immunology.

[2]  Shih-Hsiung Wu,et al.  Cyclooxygenase‐2 Regulates NLRP3 Inflammasome‐Derived IL‐1β Production , 2015, Journal of cellular physiology.

[3]  Lei Liu,et al.  Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome , 2015, Cell.

[4]  D. Steinhilber,et al.  Vitamin D in inflammatory diseases , 2014, Front. Physiol..

[5]  H. Ke,et al.  Advances in targeting cyclic nucleotide phosphodiesterases , 2014, Nature Reviews Drug Discovery.

[6]  N. Raghavachari,et al.  A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. , 2013, Endocrinology.

[7]  E. Sanchez,et al.  Reduced Adipose Tissue Macrophage Content Is Associated With Improved Insulin Sensitivity in Thiazolidinedione-Treated Diabetic Humans , 2013, Diabetes.

[8]  I. Hochberg,et al.  An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions , 2013, Nature Medicine.

[9]  S. Akira,et al.  Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome , 2012, The Journal of Immunology.

[10]  Hardy Kornfeld,et al.  Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β , 2012, Nature Immunology.

[11]  R. Germain,et al.  The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP , 2012, Nature.

[12]  Alexander S. Banks,et al.  TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis , 2012, Cell.

[13]  Richard A. Flavell,et al.  Inflammasomes in health and disease , 2012, Nature.

[14]  L. Joosten,et al.  The inflammasome puts obesity in the danger zone. , 2012, Cell metabolism.

[15]  E. Degerman,et al.  From PDE3B to the regulation of energy homeostasis. , 2011, Current opinion in pharmacology.

[16]  L. Joosten,et al.  Inflammasome is a central player in the induction of obesity and insulin resistance , 2011, Proceedings of the National Academy of Sciences.

[17]  P. Sun,et al.  Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. , 2011, Cell metabolism.

[18]  Xiangmei Zhou,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[19]  V. Manganiello,et al.  Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins* , 2011, The Journal of Biological Chemistry.

[20]  Denis Gris,et al.  Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling , 2011, Nature Immunology.

[21]  L. Joosten,et al.  The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. , 2010, Cell metabolism.

[22]  Anjana Rao,et al.  NFAT, immunity and cancer: a transcription factor comes of age , 2010, Nature Reviews Immunology.

[23]  C. Glass,et al.  Macrophages, inflammation, and insulin resistance. , 2010, Annual review of physiology.

[24]  P. Strålfors,et al.  Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes. , 2009, The Biochemical journal.

[25]  A. Tamakoshi,et al.  Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults , 2009, Disease markers.

[26]  V. Dixit,et al.  Glyburide inhibits the Cryopyrin/Nalp3 inflammasome , 2009, The Journal of cell biology.

[27]  C. Dinarello,et al.  Immunological and inflammatory functions of the interleukin-1 family. , 2009, Annual review of immunology.

[28]  Sofianos Andrikopoulos,et al.  Evaluating the glucose tolerance test in mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[29]  J. Olefsky,et al.  Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. , 2008, Cell Metabolism.

[30]  S. Brownell,et al.  Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. , 2008, Cytokine.

[31]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[32]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[33]  F. Sundler,et al.  Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. , 2006, The Journal of clinical investigation.

[34]  J. Zwerina,et al.  Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo , 2005, Arthritis research & therapy.

[35]  R. Busse,et al.  Role of macrophage tissue infiltration in metabolic diseases , 2005, Current opinion in clinical nutrition and metabolic care.

[36]  F. Sundler,et al.  β-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology* , 2004, Journal of Biological Chemistry.

[37]  Lin Chen,et al.  Transcriptional regulation by calcium, calcineurin, and NFAT. , 2003, Genes & development.

[38]  J. Abe,et al.  Role of Phosphodiesterase 3 in NO/cGMP-Mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells , 2003, Circulation research.

[39]  G. Crabtree,et al.  NFAT Signaling Choreographing the Social Lives of Cells , 2002, Cell.

[40]  W. Kolch,et al.  Regulation of Raf‐1 activation and signalling by dephosphorylation , 2002, The EMBO journal.

[41]  Qingbo Xu,et al.  Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. , 2000, Arthritis and rheumatism.

[42]  J. Kusari,et al.  Substitution of two insulin receptor carboxy-terminal tyrosines with phenylalanine impairs the expression of MAP kinase phosphatase-1 (MKP-1) mRNA , 2000, Molecular and Cellular Biochemistry.

[43]  T. Billiar,et al.  Nitric Oxide Prevents IL-1β and IFN-γ-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1β-Converting Enzyme) , 1998, The Journal of Immunology.

[44]  R. Kamen,et al.  Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production , 1997, Nature.

[45]  A. Moore,et al.  The role of cAMP regulation in controlling inflammation , 1995, Clinical and experimental immunology.

[46]  B. Franza,et al.  RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. , 1995, The EMBO journal.

[47]  H. Erdjument-Bromage,et al.  IκB-β regulates the persistent response in a biphasic activation of NF-κB , 1995, Cell.

[48]  H. Eduardo.  Nitric oxide inhibits the NLRP3 inflammasome , 2013 .

[49]  C. Tsatsanis,et al.  Signalling networks regulating cyclooxygenase-2. , 2006, The international journal of biochemistry & cell biology.

[50]  A. Hevener,et al.  IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.

[51]  M. Merville,et al.  Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. , 2005, Trends in biochemical sciences.

[52]  M. Merville,et al.  Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation , 2005 .

[53]  T. Billiar,et al.  Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme). , 1998, Journal of immunology.

[54]  R. Kamen,et al.  Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. , 1997, Nature.

[55]  D. Loskutoff,et al.  Elevated Expression of Transforming Growth Factor-β in Adipose Tissue from Obese Mice , 1997, Molecular medicine.

[56]  H. Erdjument-Bromage,et al.  I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. , 1995, Cell.