Engineered immune cells as highly sensitive cancer diagnostics

[1]  Y. Erdi.  Limits of Tumor Detectability in Nuclear Medicine and PET , 2012, Molecular imaging and radionuclide therapy.

[2]  Ash A. Alizadeh,et al.  Abstract PR09: The prognostic landscape of genes and infiltrating immune cells across human cancers , 2015 .

[3]  S. Biswas.  Metabolic Reprogramming of Immune Cells in Cancer Progression. , 2015, Immunity.

[4]  Ruth Etzioni,et al.  Early detection: The case for early detection , 2003, Nature Reviews Cancer.

[5]  J. Collins,et al.  Synthetic biology devices for in vitro and in vivo diagnostics , 2015, Proceedings of the National Academy of Sciences.

[6]  Kerstin Klinkert,et al.  Selective M2 Macrophage Depletion Leads to Prolonged Inflammation in Surgical Wounds , 2017, European Surgical Research.

[7]  Michael Baym,et al.  Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation , 2017, Nature Biotechnology.

[8]  S. Milstien,et al.  Is tail vein injection a relevant breast cancer lung metastasis model? , 2013, Journal of thoracic disease.

[9]  S. Chouaib,et al.  Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function , 2016, Front. Immunol..

[10]  O. Elemento,et al.  Challenges in Using ctDNA to Achieve Early Detection of Cancer , 2017, bioRxiv.

[11]  P. Śliwiński,et al.  Cell-free DNA levels in plasma of patients with non-small-cell lung cancer and inflammatory lung disease , 2015, British Journal of Cancer.

[12]  S. Gambhir,et al.  Artificial MicroRNAs as Novel Secreted Reporters for Cell Monitoring in Living Subjects , 2016, PloS one.

[13]  Sung Bae Kim,et al.  Split Gaussia luciferase-based bioluminescence template for tracing protein dynamics in living cells. , 2009, Analytical chemistry.

[14]  Sam Angiuoli,et al.  Direct detection of early-stage cancers using circulating tumor DNA , 2017, Science Translational Medicine.

[15]  K. Curran,et al.  Toxicity and management in CAR T-cell therapy , 2016, Molecular therapy oncolytics.

[16]  yang-xin fu,et al.  CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors , 2015, Nature Medicine.

[17]  O. Abudayyeh,et al.  Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease , 2012, Nature Biotechnology.

[18]  P. Murray,et al.  Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1 , 2004, The Journal of Immunology.

[19]  T. Ulich,et al.  The intratracheal administration of endotoxin and cytokines. I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate. , 1991, The American journal of pathology.

[20]  Amin Aalipour,et al.  Molecular profiling of single circulating tumor cells from lung cancer patients , 2016, Proceedings of the National Academy of Sciences.

[21]  B. Cullen,et al.  Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. , 1988, Gene.

[22]  C. Sheridan.  Exosome cancer diagnostic reaches market , 2016, Nature Biotechnology.

[23]  S. Goerdt,et al.  Macrophage activation and polarization: nomenclature and experimental guidelines. , 2014, Immunity.

[24]  Sanjiv S Gambhir,et al.  Mathematical Model Identifies Blood Biomarker–Based Early Cancer Detection Strategies and Limitations , 2011, Science Translational Medicine.

[25]  T. Koh,et al.  Inflammation and wound healing: the role of the macrophage , 2011, Expert Reviews in Molecular Medicine.

[26]  Michel Sadelain,et al.  Therapeutic T cell engineering , 2017, Nature.

[27]  James A. Hutchinson,et al.  DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. , 2015, Immunity.

[28]  Matthias T Stephan,et al.  In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers. , 2017, Nature nanotechnology.

[29]  Özlem Türeci,et al.  Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma , 2013, BMC Genomics.

[30]  David K. Wood,et al.  Nanoparticles That Sense Thrombin Activity As Synthetic Urinary Biomarkers of Thrombosis , 2013, ACS nano.

[31]  B. Tannous,et al.  Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo , 2009, Nature Protocols.

[32]  Johannes Griss,et al.  Tumor-associated B-cells induce tumor heterogeneity and therapy resistance , 2017, Nature Communications.

[33]  Magdalena Kowalewska,et al.  Systemic inflammation as a confounding factor in cancer biomarker discovery and validation , 2010, Nature Reviews Cancer.

[34]  E. Diamandis,et al.  Can circulating tumor DNA be used for direct and early stage cancer detection? , 2017, F1000Research.

[35]  E. Diamandis,et al.  Circulating Tumor DNA for Early Cancer Detection. , 2018, The journal of applied laboratory medicine.

[36]  S. Gambhir,et al.  Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma , 2017, Science Translational Medicine.

[37]  G. Cox.  IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils. , 1996, The American journal of physiology.

[38]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2014 .

[39]  L. Moretta,et al.  Effect of tumor cells and tumor microenvironment on NK‐cell function , 2014, European journal of immunology.

[40]  T. Hagemann,et al.  The tumor microenvironment at a glance , 2012, Journal of Cell Science.

[41]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[42]  T. Wynn,et al.  Macrophages in Tissue Repair, Regeneration, and Fibrosis. , 2016, Immunity.

[43]  C. Lewis,et al.  Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. , 2004, Blood.

[44]  M. Headley,et al.  Visualization of immediate immune responses to pioneer metastatic cells in the lung , 2016, Nature.

[45]  Sharon S. Hori,et al.  Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker , 2015, Proceedings of the National Academy of Sciences.

[46]  T. Ganz,et al.  Animal models of anemia of inflammation. , 2009, Seminars in hematology.

[47]  E. Israel,et al.  Alternative Macrophage Activation Is Increased in Asthma. , 2016, American journal of respiratory cell and molecular biology.

[48]  S. Kostin,et al.  Classically and alternatively activated macrophages contribute to tissue remodelling after myocardial infarction , 2009, Journal of cellular and molecular medicine.